[1]张 科,谷冬梅,李 波,等.当归-川芎药对治疗原发性痛经的网络药理学研究[J].医学信息,2021,34(14):92-95.[doi:10.3969/j.issn.1006-1959.2021.14.025]
　ZHANG Ke,GU Dong-mei,LI Bo,et al.A Network Pharmacological Study of Angelica-ligusticum Chuanxiong Medicine in the Treatment of Primary Dysmenorrhea[J].Medical Information,2021,34(14):92-95.[doi:10.3969/j.issn.1006-1959.2021.14.025]
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当归-川芎药对治疗原发性痛经的网络药理学研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年14期
页码:
92-95
栏目:
论著
出版日期:
2021-07-15

文章信息/Info

Title:
A Network Pharmacological Study of Angelica-ligusticum Chuanxiong Medicine in the Treatment of Primary Dysmenorrhea
文章编号:
1006-1959（2021）14-0092-04
作者:
张 科; 谷冬梅; 李 波; 等
（天津医科大学总医院药剂科1，检验科2，天津 300052）
Author(s):
ZHANG Ke; GU Dong-mei; LI Bo; et al.
(Department of Pharmacy1,Department of Laboratory Medicine2,General Hospital of Tianjin Medical University, Tianjin 300052,China)
关键词:
当归; 川芎; 原发性痛经; 网络药理学
Keywords:
Angelica; Chuanxiong; Primary dysmenorrhea; Network pharmacology
分类号:
R285
DOI:
10.3969/j.issn.1006-1959.2021.14.025
文献标志码:
A
摘要:
目的 探究当归-川芎药对治疗原发性痛经的作用机制。方法 检索TCMSP数据库中当归、川芎两味药材的成分和靶点，检索Drugbank和GeneCards数据库中原发性痛经（PD）靶点，取成分靶点与疾病靶点的交集，使用Cytoscape3.7.2软件绘制活性成分-作用靶点网络图，选出关键成分；并应用STRING数据库绘制靶点蛋白互作网络（PPI），度值高的靶点蛋白作为当归-川芎药对治疗PD的关键靶点，另应用DAVID数据库进行基因功能注释分析和功能富集分析。结果 筛选获得当归-川芎药对9个活性成分，PD相关靶点352个，活性成分-靶点网络包含8个成分（其中1个成分没有对应的靶点）和69个作用靶点，关键靶点涉及PTGS2、NCOA2、PTGS1、PRKACA、SCN5A等。PPI网络包含16个蛋白，关键蛋白涉及CASP3、PTGS2、ESR1、TGFB1等。基因功能注释分析和功能富集分析显示，当归-川芎药对治疗PD是通过参与雌二醇调节、类固醇激素介导的信号通路、NO生物合成过程的正向调节、糖皮质激素反应等生物过程，调控雌激素信号通路、NF-κB信号通路、细胞凋亡等发挥作用。结论 当归-川芎药对中多个成分作用于多个靶点和通路，可发挥治疗PD的作用。
Abstract:
Objective To explore the mechanism of Angelica-Ligusticum chuanxiong medicine on the treatment of primary dysmenorrhea.Methods Searching the components and targets of the two medicinal materials of Angelica sinensis and Chuanxiong in the TCMSP database, and search the primary dysmenorrhea(PD)targets in the Drugbank and GeneCards databases, and take the intersection of the component targets and the disease targets.Using Cytoscape 3.7.2 software to draw a network diagram of active ingredients-targets of action, and select key ingredients;And use the STRING database to draw the target protein interaction network (PPI), the target protein with high degree value is used as the key target of Angelica-Ligusticum chuanxiong medicine for the treatment of PD.In addition, DAVID database is used for gene function annotation analysis and function enrichment analysis.Results Screening obtained Angelica-Ligusticum chuanxiong drug pair 9 active ingredients, 352 PD-related targets, and the active ingredient-target network contains 8 ingredients (one ingredient had no corresponding target) and 69 targets.The key targets involve PTGS2, NCOA2, PTGS1, PRKACA, SCN5A, etc. The PPI network contained 16 proteins,the key proteins involve CASP3, PTGS2, ESR1, TGFB1 and so on.Gene function annotation analysis and function enrichment analysis show,Angelica-Ligusticum chuanxiong medicine treated PD by participating in biological processes such as estradiol regulation, steroid hormone-mediated signaling pathways, positive regulation of NO biosynthesis process, and glucocorticoid response.Regulate estrogen signaling pathway, NF-κB signaling pathway, cell apoptosis, etc. to play a role.Conclusion Multiple components in the Angelica-Ligusticum chuanxiong drug pair act on multiple targets and pathways, and play a role in the treatment of PD.

参考文献/References:

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更新日期/Last Update: 1900-01-01