[1]舒 密.外泌体miRNAs在结直肠癌中的研究进展[J].医学信息,2021,34(15):15-18.[doi:10.3969/j.issn.1006-1959.2021.15.004]
 SHU Mi.Research Progress of Exosomal miRNAs in Colorectal Cancer[J].Medical Information,2021,34(15):15-18.[doi:10.3969/j.issn.1006-1959.2021.15.004]
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外泌体miRNAs在结直肠癌中的研究进展()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年15期
页码:
15-18
栏目:
综述
出版日期:
2021-08-01

文章信息/Info

Title:
Research Progress of Exosomal miRNAs in Colorectal Cancer
文章编号:
1006-1959(2021)15-0015-04
作者:
舒 密
(湖南医药学院第一附属医院消化内科,湖南 怀化 418000)
Author(s):
SHU Mi
(Department of Gastroenterology,the First Affiliated Hospital of Hunan University of Medicine,Huaihua 418000,Hunan,China)
关键词:
外泌体miRNAs肿瘤结直肠癌
Keywords:
ExosomesmiRNAsTumorsColorectal cancer
分类号:
R735.7;Q522
DOI:
10.3969/j.issn.1006-1959.2021.15.004
文献标志码:
A
摘要:
外泌体是具有双膜结构的直径为30~150 nm微小膜(囊)泡,其内包裹着大量的蛋白质、核酸、miRNAs、mRNA等物质。广泛存在于血清、脑脊液和乳汁等人体体液中,参与细胞间的信号传递和物质交换等过程。目前外泌体miRNAs在结直肠癌中作用的研究是近年来的研究热点。由于外泌体所包裹的miRNAs具有特异性和稳定性,在正常和病变部分具有不同的表达趋势,且在人体内广泛稳定存在,使得获取和检测便捷,故其有望成为结直肠癌诊治的新型无创的生物标志物。本文对血清外泌体miRNAs与结直肠癌的关系做一综述。
Abstract:
Exosomes are tiny membrane (vesicles) with a diameter of 30-150 nm with a double-membrane structure, which are packed with a large number of proteins, nucleic acids, miRNAs, mRNA and other substances.It is widely present in human body fluids such as serum, cerebrospinal fluid and breast milk, and participates in the signal transmission and material exchange processes between cells.At present, the research on the role of exosomal miRNAs in colorectal cancer has been a research hotspot in recent years.Because the miRNAs encapsulated by exosomes have specificity and stability, they have different expression trends in normal and diseased parts, and they are widely and stably present in the human body, making it easy to obtain and detect.Therefore, it is expected to become a new non-invasive biomarker for the diagnosis and treatment of colorectal cancer.This article reviews the relationship between serum exosomal miRNAs and colorectal cancer.

参考文献/References:

[1]王振军,付李缘.大肠癌筛查共识与争议[J].临床外科杂志,2018,26(10):721-723. [2]褚锋,杨侃侃,李启信.青年结直肠癌患者的临床病理特征及预后分析[J].医学信息,2021,34(2):5-7. [3]Zhang J,Li S,Li L,et al.Exosome and exosomal microRNA:trafficking,sorting,and function[J].Genomics Proteomics Bioinformatics,2015,13(1):17-24. [4]Falcone G,Felsani A,D’Agnano I.Signaling by exosomal microRNAs in cancer[J].J Exp Clin Cancer Res,2015(34):32. [5]Zhang J,Li S,Li L,et al.Exosome and Exosomal MicroRNA:Trafficking,Sorting,and Function [J].Genom Proteom Bioinf,2015,13(1):17-24. [6]Zhu W,Huang L,Li Y,et al.Exosome derivedfrom human bone marrow mesenchymal stem cells promote tumor growth in vivo[J].Cancer Lett,2012,315(1):28-37. [7]Théry C,Ostrowski M,Segura E.Membrane vesicles as conveyors of immune responses[J].Nat Rev Immunol,2009,9(8):581-593. [8]Johnstone RM,Adam M,Hammond JR,et al.Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes)[J].J Biol Chem,1987,262(19):9412-9420. [9]Tang MK,Wong AS.Exosomes:Emerging biomarkers and targets for ovarian cancer[J].Cancer Lett,2015,367(1):26-33. [10]Hou J,Wang F,Liu X,et al.Tumor-derived exosomes enhance invasion and metastasis of salivary adenoid cystic carcinoma cells[J].J Oral Pathol Med,2017,47(2):144-151. [11]Chen W,Jiang J,Xia W,et al.Tumor-Related Exosomes Contribute to Tumor-Promoting Microenvironment: An Immunological Perspective[J].Clin Dev Immunol,2017(2017):1073947. [12]Carter JV,Roberts HL,Pan J,et al.A Highly Predictive Model for Diagnosis of Colorectal Neoplasms Using Plasma MicroRNA:Improving Specificity and Sensitivity[J].Ann Surg,2016,264(4):575-584. [13]Yin Y,Song M,Gu B,et al.Systematic analysis of key miRNAs and related signaling pathways in colorectal tumorigenesis[J].Gene,2016,578(2):177-184. [14]Tateishi Y,Okudela K,Mitsui H,et al.The potential role of microRNA-31 expression in early colorectal cancer[J].Pathol Int,2015,65(10):513-518. [15]Lin M,Duan B,Hu J,et al.Decreased expression of miR-193a-3p is associated with poor prognosis in colorectal cancer[J].Oncol Lett,2017,14(1):1061-1067. [16]Sugawara S,Yamada Y,Arai T,et al.Dual strands of the miR-223 duplex (miR-223-5p and miR-223-3p)inhibit cancer cell aggressiveness: targeted genes are involved in bladder cancer pathogenesis[J].J Hum Genet,2018,63(5):657-668. [17]Pardini B,De Maria D,Francavilla A,et al.MicroRNAs as markers of progression in cervical cancer:A systematic review[J].BMC Cancer,2018,18(1):696. [18]Wang X,Tong Z,Liu H.MiR-223-3p targeting epithelial cell transforming sequence 2 oncogene inhibits the activity,apoptosis,invasion and migration of MDA-MB-468 breast cancer cells[J].Onco Targets Ther,2019(12):7675-7684 [19]Yoshikawa M,Iinuma H,Umemoto Y,et al.Exosome encapsulated microRNA-223-3p as a minimally invasive biomarker for the early detection of invasive breast cancer[J].Oncol Lett,2018,15(6):9584-9592. [20]Ma J,Xu M,Yin M,et al.Exosomal hsa-miR199a-3p PromotesProliferation and Migration inNeuroblastoma[J].Front Oncol,2019,9(459):1-13. [21]Zhao S,Li J,Zhang G,et al.Exosomal miR-451a Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Targeting LPIN1[J].Cell Physiol Biochem,2019,53(1):19-35. [22]Cui Y,Xu HF,Liu MY,et al.Mechanism of exosomal microRNA-224 in development of hepatocellular carcinoma and its diagnostic and prognostic value[J].World J Gastroenterol,2019,25(15): 1890-1898. [23]Karimi N,Ali Hosseinpour Feizi M,Safaralizadeh R,et al.Serum overexpression of miR-301a and miR-23ain patients with colorectal cancer[J].J Chin Med Assoc,2019,82(3):215-220. [24]Hu HY,Yu CH,Zhang HH,et al.Exosomal miR-1229 derived from colorectal cancer cells promotes angiogenesis by targeting HIPK2[J].Int J Biol Macromol,2019(132):470-477. [25]Zhao YJ,Song X,Niu L,et al.Circulating Exosomal miR-150-5pand miR-99b-5p as DiagnosticBiomarkers for Colorectal Cancer[J].Front Oncol,2019(9):1129. [26]Yan S,Bing H,Gao S,et al.Exosome-encapsulated microRNAs as circulating biomarkers for colorectal cancer[J].Oncotarget,2017,8(36):60149-60158. [27]Peng ZY, Gu RH, Yan B.Downregulation of exosome-encapsulated miR-548c-5p is associated with poor prognosis in colorectal cancer[J].J Cell Biochem,2018,120(2):1457-1463. [28]Yan S,Jiang Y,Liang C,et al.Exosomal miR-6803-5p as potential diagnostic and prognostic marker in colorectal cancer[J].J Cell Biochem,2018,119(5):4113-4119. [29]Yan S,Liu G, Jin C,et al.MicroRNA-6869-5p acts as a tumor suppressor via targeting TLR4/NF-κB signaling pathway in colorectal cancer[J].J Cell Physiol,2018,233(9):6660-6668. [30]Gu YY,Yu J,Zhang JF,et al.Suppressing the secretion of exosomal miR-19b by gw4869 could regulate oxaliplatin sensitivity in colorectal cancer[J].Neoplasma,2019,66(1):39-45. [31]Zou SL,Chen YL,Ge ZZ,et al.Downregulation of serum exosomal miR-150-5p is associated with poor prognosis in patients with colorectal cancer[J].Cancer Biomark,2019,26(1):69-77.

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更新日期/Last Update: 1900-01-01