[1]廖 翔.人血白蛋白联合呋塞米对肝硬化难治性腹水患者肝肾功能的影响[J].医学信息,2021,34(21):106-108.[doi:10.3969/j.issn.1006-1959.2021.21.028]
　LIAO Xiang.Effect of Human Blood Albumin Combined with Furosemide on Liver and Kidney Function in Patients with Cirrhosis-refractory Ascites[J].Medical Information,2021,34(21):106-108.[doi:10.3969/j.issn.1006-1959.2021.21.028]
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人血白蛋白联合呋塞米对肝硬化难治性腹水患者肝肾功能的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年21期
页码:
106-108
栏目:
论著
出版日期:
2021-11-01

文章信息/Info

Title:
Effect of Human Blood Albumin Combined with Furosemide on Liver and Kidney Function in Patients with Cirrhosis-refractory Ascites
文章编号:
1006-1959（2021）21-0106-03
作者:
廖 翔
（龙南妇幼保健院内科，江西 龙南 341700）
Author(s):
LIAO Xiang
(Department of Internal,Longnan Maternal and Child Health Hospital,Longnan 341700,Jiangxi,China)
关键词:
难治性腹水; 人血白蛋白; 呋塞米; 肝肾功能
Keywords:
Refractory ascites; Human albumin; Furosemide; Liver and kidney function
分类号:
R575.2
DOI:
10.3969/j.issn.1006-1959.2021.21.028
文献标志码:
A
摘要:
目的 探讨人血白蛋白联合呋塞米对肝硬化难治性腹水（RA）患者肝肾功能的影响。方法 选取2019年1月-2020年1月我院接受治疗的RA患者80例为研究对象，采用随机数字表法分为对照组和观察组，各40例。对照组给予呋塞米治疗，观察组给予人血白蛋白联合呋塞米治疗，比较两组临床治疗疗效、临床指标（腹围、体重及心率）、肝功能[白蛋白（ALB）、总胆红素（TBIL）、谷丙转氨酶（ALT）]、肾功能[血肌酐（Scr）、尿素氮（BUN）、24h尿蛋白定量（NDBDL）]及不良反应发生情况。结果 观察组药物治疗总有效率高于对照组，差异有统计学意义（P＜0.05）；观察组腹围、体重及心率低于对照组，差异有统计学意义（P＜0.05）；观察组ALB水平高于对照组，TBIL、ALT、Scr、BUN、NDBDL水平低于对照组，差异有统计学意义（P＜0.05）；观察组不良反应发生率低于对照组，差异有统计学意义（P＜0.05）。结论 人血白蛋白联合呋塞米治疗RA疗效确切，能够促进肝、肾功能恢复，且药物联合应用不良反应较少。
Abstract:
Objective To investigate the effect of human serum albumin combined with furosemide on liver and kidney function in patients with cirrhosis-refractory ascites (RA).Methods A total of 80 patients with RA treated in our hospital from January 2019 to January 2020 were selected and randomly divided into control group and observation group, with 40 cases in each group. The control group was treated with furosemide, and the observation group was treated with human serum albumin combined with furosemide. The clinical efficacy, clinical indexes (abdominal circumference, body weight and heart rate), liver function [albumin (ALB), total bilirubin (TBIL), alanine aminotransferase (ALT)], renal function [serum creatinine (Scr), urea nitrogen (BUN), 24 h urinary protein quantification (NDBDL)] and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). The abdominal circumference, weight and heart rate of the observation group were lower than those of the control group, and the difference was statistically significant (P<0.05). The level of ALB in the observation group was higher than that in the control group, the levels of TBIL, ALT, Scr, BUN and NDBDL in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05). The incidence of adverse reactions in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05).Conclusion Human albumin combined with furosemide is effective in the treatment of RA, which can promote the recovery of liver and kidney function, and the combination of drugs has less adverse reactions.

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更新日期/Last Update: 1900-01-01