[1]田跃雷,李春彦.丹参多酚酸盐对急诊PCI患者术后氧化应激、心功能、血管内皮功能的影响[J].医学信息,2022,35(04):156-158.[doi:10.3969/j.issn.1006-1959.2022.04.041]
　TIAN Yue-lei,LI Chun-yan.Effect of Salvianolate on Oxidative Stress, Cardiac Function and Vascular Endothelial Functionin Patients After Emergency PCI[J].Medical Information,2022,35(04):156-158.[doi:10.3969/j.issn.1006-1959.2022.04.041]
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丹参多酚酸盐对急诊PCI患者术后氧化应激、心功能、血管内皮功能的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年04期
页码:
156-158
栏目:
药物与临床
出版日期:
2022-02-15

文章信息/Info

Title:
Effect of Salvianolate on Oxidative Stress, Cardiac Function and Vascular Endothelial Functionin Patients After Emergency PCI
文章编号:
1006-1959（2022）04-0156-03
作者:
田跃雷1; 李春彦2
1.天津医科大学总医院滨海医院心内科，天津 300480；2.河北北方学院附属第二医院心内科，河北 张家口 075100
Author(s):
TIAN Yue-lei1; LI Chun-yan2
1.Department of Cardiology,General Hospital Affiliated to Tianjin Medical University Binhai Hospital,Tianjin 300480,China;2.Department of Cardiology,the Second Affiliated Hospital of Hebei North University,Zhangjiakou 075100,Hebei,China
关键词:
丹参多酚酸盐; 经皮冠状动脉介入术; 心功能; 血管内皮功能
Keywords:
Salvianolate; Percutaneous coronary intervention; Cardiac function; Vascular endothelial function
分类号:
R541.4
DOI:
10.3969/j.issn.1006-1959.2022.04.041
文献标志码:
A
摘要:
目的 研究丹参多酚酸盐对急诊经皮冠状动脉介入术（PCI）患者术后氧化应激、心功能、血管内皮功能的影响。方法 选取2017年10月-2018年9月我院治疗的80例急诊PCI术患者为研究对象，采用随机数字表法分为对照组和观察组，各40例。对照组给予阿司匹林、氢氯吡格雷治疗，观察组在对照组基础上给予丹参多酚酸盐治疗，比较两组氧化应激指标[丙二醛（MDA）、吞噬细胞还原型辅酶Ⅲ氧化酶（NADPH氧化酶）p22phox活性]、心功能指标[左心室舒张末期内径（LVEDD）、左心室射血分数（LVEF）]、血管内皮功能[内皮素（ET）、一氧化氮（NO）]、不良反应发生情况以及心血管事件和再狭窄发生率。结果 观察组MDA、NADPH氧化酶p22phox活性低于对照组，差异有统计学意义（P＜0.05）；观察组LVEF高于对照组，LVEDD低于对照组，差异有统计学意义（P＜0.05）；观察组ET低于对照组，NO高于对照组，差异有统计学意义（P＜0.05）；观察组不良反应发生率为7.50%，与对照组的10.00%比较，差异无统计学意义（P＞0.05）；观察组心血管事件发生率、术后再狭窄发生率低于对照组，差异有统计学意义（P＜0.05）。结论 丹参多酚酸盐可减轻急诊PCI患者氧化应激反应，改善心功能和血管内皮功能，且可降低心血管事件及再狭窄发生几率，用药安全性良好。
Abstract:
Objective To study the effect of salvianolate on oxidative stress, cardiac function and vascular endothelial function in patients after emergency percutaneous coronary intervention (PCI).Methods A total of 80 patients with emergency PCI treated in our hospital from October 2017 to September 2018 were selected as the study subjects. They were divided into control group and observation group by random number table method, with 40 cases in each group. The control group was treated with aspirin and clopidogrel, and the observation group was treated with salvianolate on the basis of the control group. The oxidative stress indexes [malondialdehyde (MDA), NADPH oxidase (NADPH oxidase) p22phox activity], cardiac function indexes [left ventricular end-diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF)], vascular endothelial function [endothelin (ET), nitric oxide (NO)], incidence of adverse reactions, and incidence of cardiovascular events and restenosis were compared between the two groups.Results The activities of MDA and NADPH oxidase p22phox activity in the observation group were lower than those in the control group, and the differences were statistically significant (P<0.05). LVEF in the observation group was higheqr than that in the control group, LVEDD was lower than that in the control group, and the difference was statistically significant (P<0.05).ET in the observation group was lower than that in the control group, and NO was higher than that in the control group, the difference was statistically significant (P<0.05). The incidence of adverse reactions in the observation group was 7.50%, which was compared with 10.00% in the control group, the difference was not statistically significant (P>0.05). The incidence of cardiovascular events and postoperative restenosis in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05).Conclusion Salvianolate can reduce oxidative stress in patients with emergency PCI, improve cardiac function and vascular endothelial function, and reduce the incidence of cardiovascular events and restenosis, with good safety.

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更新日期/Last Update: 1900-01-01