[1]靳春鹏.佐匹克隆与艾司唑仑治疗老年睡眠障碍的疗效比较[J].医学信息,2022,35(05):162-164.[doi:10.3969/j.issn.1006-1959.2022.05.043]
　JIN Chun-peng.Comparison of Clinical Efficacy of Zopiclone and Estazolam in the Treatment of Elderly Sleep Disorders[J].Medical Information,2022,35(05):162-164.[doi:10.3969/j.issn.1006-1959.2022.05.043]
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佐匹克隆与艾司唑仑治疗老年睡眠障碍的疗效比较()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年05期
页码:
162-164
栏目:
药物与临床
出版日期:
2022-03-01

文章信息/Info

Title:
Comparison of Clinical Efficacy of Zopiclone and Estazolam in the Treatment of Elderly Sleep Disorders
文章编号:
1006-1959（2022）05-0162-03
作者:
靳春鹏
（北京市普仁医院医务科，北京 100062）
Author(s):
JIN Chun-peng
(Medical Department of Beijing Puren Hospital,Beijing 100062,China)
关键词:
佐匹克隆; 艾司唑仑; 老年; 睡眠障碍
Keywords:
Zopiclone;  Estazolam; Elderly; Sleep disorder
分类号:
R749.05
DOI:
10.3969/j.issn.1006-1959.2022.05.043
文献标志码:
A
摘要:
目的 观察佐匹克隆与艾司唑仑治疗老年睡眠障碍的临床疗效。方法 选取2020年4月-2021年4月我院接诊的64例睡眠障碍老年患者为研究对象，采用随机数字表法分为观察组和对照组，各32例。对照组单纯给予艾司唑仑治疗，观察组给予佐匹克隆治疗，比较两组总有效率、睡眠障碍（SDRS）评分、匹兹堡睡眠质量评分（PSQI）、病理行为（BEHA VE-AD）评分以及不良反应发生情况。结果 观察组总有效率为93.75%，高于对照组的81.25%，差异有统计学意义（P＜0.05）；两组SDRS评分均低于治疗前，且观察组低于对照组，差异有统计学意义（P＜0.05）；观察组觉醒次数、入眠时间低于对照组，睡眠时间大于对照组，BEHA VE-AD 量表各维度评分均低于对照组，差异有统计学意义（P＜0.05）；观察组不良反应发生率为9.38%，低于对照组的21.88%，差异有统计学意义（P＜0.05）。结论 采用佐匹克隆治疗老年睡眠障碍总有效率高于艾司唑仑，能显著改善睡眠障碍，提高睡眠质量，减轻病理行为，且不良反应少，具有相对理想的有效性和安全性。
Abstract:
Objective To observe the clinical effect of zopiclone and estazolam in the treatment of senile sleep disorder.Methods A total of 64 elderly patients with sleep disorders admitted to our hospital from April 2020 to April 2021 were selected as the research subjects. They were divided into observation group and control group by random number table method, with 32 cases in each group. The control group was treated with esazolam only, and the observation group was treated with zopiclone. The total effective rate, sleep disorder (SDRS) score, Pittsburgh sleep quality score (PSQI), pathological behavior (BEHA VE-AD) score and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 93.75%, which was higher than 81.25% of the control group, and the difference was statistically significant (P<0.05). The SDRS scores of the two groups were lower than those before treatment, and the observation group was lower than the control group, the difference was statistically significant (P<0.05). The number of awakenings and sleep time in the observation group were lower than those in the control group, and the sleep time was longer than that in the control group. The scores of each dimension of BEHA VE-AD scale were lower than those in the control group, and the difference was statistically significant (P<0.05). The incidence of adverse reactions in the observation group was 9.38%, which was lower than 21.88% in the control group, and the difference was statistically significant (P<0.05).Conclusion The total effective rate of zopiclone in the treatment of elderly patients with sleep disorders is higher than that of esazolam, which can significantly improve sleep disorders, improve sleep quality, and reduce pathological behavior, with less adverse reactions, and relatively ideal effectiveness and safety.

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更新日期/Last Update: 1900-01-01