[1]张亚男,谢 文,肖 鹏,等.可降解镁合金骨植入对大鼠肝肾功能影响的实验研究[J].医学信息,2022,35(07):92-94.[doi:10.3969/j.issn.1006-1959.2022.07.022]
　ZHANG Ya-nan,XIE Wen,XIAO Peng,et al.Experimental Study on the Effects of Degradable Magnesium Alloy Bone Implantation on Blood Routine and Liver and Kidney Function in Rats[J].Medical Information,2022,35(07):92-94.[doi:10.3969/j.issn.1006-1959.2022.07.022]
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可降解镁合金骨植入对大鼠肝肾功能影响的实验研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年07期
页码:
92-94
栏目:
论著
出版日期:
2022-04-01

文章信息/Info

Title:
Experimental Study on the Effects of Degradable Magnesium Alloy Bone Implantation on Blood Routine and Liver and Kidney Function in Rats
文章编号:
1006-1959（2022）07-0092-03
作者:
张亚男; 谢 文; 肖 鹏; 等
（1.湖南中医药大学针灸推拿与康复学院，湖南 长沙 410000；2.河南省洛阳正骨医院/河南省骨科医院医学检验中心，河南 洛阳 471000；3.河南省正骨研究院医学实验研究中心/河南省骨科医疗器械工程技术研究中心，河南 洛阳 471000）
Author(s):
ZHANG Ya-nan; XIE Wen; XIAO Peng; et al.
(1.College of Acupuncture and Massage,Hunan University of Chinese Medicine,Changsha 410000，Hunan,China;2.Medical Laboratory Center,Henan Luoyang Orthopedic Hospital/Henan Orthopedic Hospital,Luoyang 471000,Henan,China;3.Medical Experimental Research Cen
关键词:
镁合金; 降解; 血常规; 肝肾功能; 大鼠
Keywords:
Magnesium alloys; Degradation; Routine blood test; Liver and kidney function; Rat
分类号:
R687.3+2；
DOI:
10.3969/j.issn.1006-1959.2022.07.022
文献标志码:
A
摘要:
目的 观察可降解镁合金材料骨植入对大鼠肝、肾组织功能和结构的影响。方法 将体重200~300 g的SD大鼠12只采用随机数字表法分为对照组和实验组，每组6只。实验组大鼠双侧股骨髁骨植入WE43镁合金试样，对照组大鼠双侧股骨髁部位只切开皮肤即缝合，不做植入处理；两组术后采用同样的抗菌素处理，并在相同的条件下饲养。比较两组术后3个月血WBC、RBC、Hb、HCT、PLT、ALT、AST、γ-GT、ALP、BUN、Cr、UA水平，观察大鼠肝脏、肾脏和脾脏组织变化。结果 实验组WBC、RBC、Hb、HCT、PLT、ALP、BUN、Cr水平低于对照组，ALT、AST、γ-GT水平均高于对照组，但差异无统计学意义（P＞0.05）；实验组UA低于对照组，差异有统计学意义（P＜0.05）；病理检查结果显示，实验组动物肝、肾组织形态结构正常。结论 WE43镁合金骨植入可降低大鼠血UA水平，但对血常规、肝功、其他肾功能指标及其组织结构可能无影响。
Abstract:
Objective To observe the effects of biodegradable magnesium alloy bone implantation on the function and structure of liver and kidney in rats.Methods SD rats weighing 200-300 g were randomly divided into control group and experimental group, with 6 rats in each group. WE43 magnesium alloy samples were implanted into bilateral femoral condyles of rats in the experimental group, while the skin of bilateral femoral condyles of rats in the control group was only cut and sutured without implantation treatment. The two groups were treated with the same antibiotics after operation and raised under the same conditions. The blood WBC, RBC, Hb, HCT, PLT, ALT, AST, γ-GT, ALP, BUN, Cr and UA levels in the two groups were compared 3 months after operation, and the changes of liver, kidney and spleen tissues in rats were observed.Results The levels of WBC, RBC, Hb, HCT, PLT, ALP, BUN and Cr in the experimental group were lower than those in the control group, and the levels of ALT, AST and γ-GT were higher than those in the control group, but the difference was not statistically significant (P>0.05). The level of UA in the experimental group was lower than that in the control group, and the difference was statistically significant (P<0.05). The pathological examination results showed that the liver and kidney tissues in the experimental group were normal.Conclusion WE43 magnesium alloy bone implantation can reduce the serum uric acid level in rats, but it may not affect blood routine, liver function, other renal function indexes and their tissue structure.

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更新日期/Last Update: 1900-01-01