[1]薛守宇,廉 婷,耿爱民.补中益气活血方对胃溃疡患者血清TFF2和SOD水平的影响[J].医学信息,2022,35(10):105-108.[doi:10.3969/j.issn.1006-1959.2022.10.025]
　XUE Shou-yu,LIAN Ting,GENG Ai-min.Effect of Buzhong Yiqi Huoxue Recipe on Serum Levels of TFF2 and SOD in Patients with Gastric Ulcer[J].Medical Information,2022,35(10):105-108.[doi:10.3969/j.issn.1006-1959.2022.10.025]
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补中益气活血方对胃溃疡患者血清TFF2和SOD水平的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年10期
页码:
105-108
栏目:
论著
出版日期:
2022-05-15

文章信息/Info

Title:
Effect of Buzhong Yiqi Huoxue Recipe on Serum Levels of TFF2 and SOD in Patients with Gastric Ulcer
文章编号:
1006-1959（2022）10-0105-04
作者:
薛守宇; 廉 婷; 耿爱民
（1.西安医学院临床医学院，陕西 西安 710021；2.长安医院泌尿外科，陕西 西安 710000）
Author(s):
XUE Shou-yu; LIAN Ting; GENG Ai-min
(1.School of Clinical Medicine,Xi’an Medical University,Xi’an 710021,Shaanxi,China;2.Department of Urology,Chang’an Hospital,Xi’an 710000,Shaanxi,China)
关键词:
补中益气活血方; 胃溃疡; 血清TFF2; SOD
Keywords:
Buzhong Yiqi Huoxue Recipe; Gastric ulcer; Serum TFF2; SOD
分类号:
R285
DOI:
10.3969/j.issn.1006-1959.2022.10.025
文献标志码:
A
摘要:
目的 观察补中益气活血方对胃溃疡患者血清TFF2和SOD水平的影响。方法 选取2020年1月-2021年1月在长安医院诊治的58例胃溃疡患者为研究对象，采用随机数字表法分为对照组和观察组，各29例。对照组采用奥美拉唑联合克拉霉素治疗，观察组在对照组基础上补中益气活血方治疗，连续治疗3个月。比较两组治疗总有效率、中医证候评分、血清TFF2和SOD水平、临床症状消失和溃疡愈合时间、不良反应发生率以及复发率。结果 观察组总有效率为86.21%，高于对照组的75.86%（P＜0.05）；两组中医证候评分均降低，且观察组低于对照组（P＜0.05）；两组血清TFF2、SOD水平均高于治疗前，且观察组高于对照组（P＜0.05）；观察组临床胃痛、反酸、早饱症状消失时间和溃疡愈合时间均短于对照组（P＜0.05）；观察组不良反应发生率为6.90%，与对照组的10.34%比较，差异无统计学意义（P＞0.05）；随访2个月，观察组复发率为13.79%，低于对照组的24.14%（P＜0.05）。结论 补中益气活血方治疗胃溃疡效果确切，可提高治疗总有效率，降低中医证候评分，缩短症状消失和溃疡愈合时间，提高血清TFF2、SOD水平，降低复发率，且不会增加临床不良反应，具有应用有效性和安全性。
Abstract:
Objective To observe the effect of Buzhong Yiqi Huoxue Recipe on serum TFF2 and SOD levels in patients with gastric ulcer.Methods A total of 58 patients with gastric ulcer who were treated in Chang’an Hospital from January 2020 to January 2021 were selected as the research objects. They were divided into control group and observation group by random number table method, with 29 cases in each group. The control group was treated with omeprazole combined with clarithromycin, and the observation group was treated with Buzhong Yiqi Huoxue Recipe on the basis of the control group. After 3 months of continuous treatment, the total effective rate, TCM syndrome score, serum TFF2 and SOD levels, disappearance of clinical symptoms and ulcer healing time, incidence of adverse reactions and recurrence rate were compared between the two groups.Results The total effective rate of the observation group was 86.21%, which was higher than 75.86% of the control group (P<0.05). The TCM syndrome scores of the two groups were decreased, and those of the observation group were lower than those of the control group (P<0.05). The levels of serum TFF2 and SOD in the two groups were higher than those before treatment, and the observation group was higher than the control group (P<0.05). The disappearance time of clinical stomach pain, acid regurgitation, early satiety and ulcer healing time in the observation group were shorter than those in the control group (P<0.05). The incidence of adverse reactions in the observation group was 6.90%, which was compared 10.34% in the control group, the difference was not statistically significant (P>0.05). After two months of follow-up, the recurrence rate in the observation group was 13.79%, which was lower than 24.14% in the control group(P<0.05).Conclusion Buzhong Yiqi Huoxue Recipe is effective in the treatment of gastric ulcer, which can improve the total effective rate, reduce the TCM syndrome score, shorten the time of symptom disappearance and ulcer healing, improve the levels of serum TFF2 and SOD, reduce the recurrence rate, and do not increase the clinical adverse reactions. It is effective and safe.

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更新日期/Last Update: 1900-01-01