[1]曾 意,汤永红,张 平.CYP2C19基因多态性与复发性缺血性卒中关系的研究[J].医学信息,2022,35(11):22-24.[doi:10.3969/j.issn.1006-1959.2022.11.007]
 ZENG Yi,TANG Yong-hong,ZHANG Ping.Study on Correlation Between CYP2C19 Gene Polymorphism and Recurrent Ischemic Stroke[J].Medical Information,2022,35(11):22-24.[doi:10.3969/j.issn.1006-1959.2022.11.007]
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CYP2C19基因多态性与复发性缺血性卒中关系的研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年11期
页码:
22-24
栏目:
综述
出版日期:
2022-06-01

文章信息/Info

Title:
Study on Correlation Between CYP2C19 Gene Polymorphism and Recurrent Ischemic Stroke
文章编号:
1006-1959(2022)11-0022-03
作者:
曾 意汤永红张 平
(南华大学附属南华医院神经内科1,临床研究所2,湖南 衡阳 421000)
Author(s):
ZENG YiTANG Yong-hongZHANG Ping
(Department of Neurology1,Clinical Research Institute2,Affiliated Nanhua Hospital,University of South ChinaHengyang 421000,Hunan,China)
关键词:
CYP2C19基因多态性缺血性卒中氯吡格雷抵抗脂质代谢
Keywords:
CYP2C19Gene polymorphismIschemic strokeClopidogrel resistanceLipid metabolism
分类号:
R743.3
DOI:
10.3969/j.issn.1006-1959.2022.11.007
文献标志码:
A
摘要:
CYP2C19作为人体中重要的药物代谢酶之一,已成为了近年来基因组学的关注热点,其基因多态性不仅影响氯吡格雷抗血小板反应性,且对脂质代谢、血压及血管炎症具有一定的调节作用。本文主要就CYP2C19基因多态性与缺血性卒中复发的相关性进行综述,以期为降低缺血性卒中患者的复发率,改善缺血性卒中患者的生活质量提供科学参考依据。
Abstract:
As one of the important drug metabolism enzymes in the human body, CYP2C19 has become a hot spot of genomics in recent years. It’s gene polymorphism not only affects the antiplatelet reactivity of clopidogrel, but also has a certain regulatory effect on lipid metabolish, blood pressure and vascular inflammation. This article mainly reviews the correlation between CYP2C19 gene polymorphism and ischemic stroke recurrence, and provides a scientific reference for reducing the recurrence rate of ischemic stroke patients and improving the quality of life of stroke patients.

参考文献/References:

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更新日期/Last Update: 1900-01-01