[1]周 慧,陈治国.脑卒中患者肠屏障功能的变化及其影响因素分析[J].医学信息,2022,35(13):142-145.[doi:10.3969/j.issn.1006-1959.2022.13.034]
　ZHOU Hui,CHEN Zhi-guo.Changes of Intestinal Barrier Function and its Influencing Factors in Stroke Patients[J].Medical Information,2022,35(13):142-145.[doi:10.3969/j.issn.1006-1959.2022.13.034]
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脑卒中患者肠屏障功能的变化及其影响因素分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年13期
页码:
142-145
栏目:
论著
出版日期:
2022-07-01

文章信息/Info

Title:
Changes of Intestinal Barrier Function and its Influencing Factors in Stroke Patients
文章编号:
1006-1959（2022）13-0142-04
作者:
周 慧; 陈治国
（苏州大学附属第一医院临床营养科1，神经内科2，江苏 苏州 215000）
Author(s):
ZHOU Hui; CHEN Zhi-guo
(Department of Clinical Nutrition1,Department of Neurology2,the First Affiliated Hospital of Soochow University,Suzhou 215000,Jiangsu,China)
关键词:
脑卒中; 肠屏障; 二胺氧化酶; D-乳酸; 内毒素
Keywords:
Stroke; Intestinal barrier; Diamine oxidase; D-lactate; Endotoxin
分类号:
R373.2
DOI:
10.3969/j.issn.1006-1959.2022.13.034
文献标志码:
A
摘要:
目的 探讨脑卒中患者肠屏障功能的变化，分析相关影响因素。方法 选取2020年7月-2021年7月我院收治的脑卒中患者64例，定量检测血清二胺氧化酶（DAO）、D-乳酸、内毒素水平，并行体成分分析检测，通过多因素Logistic分析肠屏障功能的影响因素，探讨BMI、FFMI与肠屏障之间的关系。结果 64例患者中DAO、D-乳酸、内毒素升高分别为23例、20例、3例；多因素Logistic回归分析显示，白蛋白是DAO的影响因素，前白蛋白、血糖是D-乳酸的影响因素；不同BMI、FFMI水平的脑卒中患者DAO、D-乳酸、内毒素水平比较，差异均无统计学意义（P＞0.05）。结论 脑卒中易合并肠屏障功能障碍，这种功能障碍可能与蛋白、血糖水平相关。
Abstract:
Objective To investigate the changes of intestinal barrier function in stroke patients and analyze the related influencing factors.Methods A total of 64 stroke patients admitted to our hospital from July 2020 to July 2021 were selected. The levels of serum diamine oxidase (DAO), D-lactic acid and endotoxin were quantitatively detected, and body composition analysis was performed. The influencing factors of intestinal barrier function were studied by multivariate logistic analysis, and the relationship between BMI, FFMI and intestinal barrier was discussed by T test.Results DAO, D-lactic acid and endotoxin were elevated in 23 cases, 20 cases and 3 cases, respectively. Multivariate Logistic regression analysis showed that albumin was the influencing factor of DAO, prealbumin and blood glucose were the influencing factors of D-lactic acid. There was no significant difference in DAO, D-lactic acid and endotoxin levels among stroke patients with different BMI and FFMI levels (P>0.05).Conclusion Stroke is associated with intestinal barrier dysfunction, which may be associated with protein and blood glucose levels.

参考文献/References:

[1]Johnson W,Onuma O,Owolabi M,et al.Stroke: A global response is needed[J].Bull World Health Organ,2016,94(9):634-634A.[2]Camara-Lemarroy CR,Ibarra-Yruegas BE,Gongora-Rivera F.Gastrointestinal complications after ischemic stroke[J].J Neurol Sci,2014,346(1-2):20-25.[3]Vahlberg B,Zetterberg L,Lindmark B,et al.Functional performance, nutritional status, and body composition in ambulant community-dwelling individuals 1-3 years after suffering from a cerebral infarction or intracerebral bleeding[J].BMC Geriatr,2016,16:48.[4]王建华,冯玫,乔爱春,等.脑梗死合并肌少症患者的临床特征及相关影响因素研究[J].中华全科医师杂志,2020,19(9):824-828.[5]Zhao S,Zhang T,Li B,et al.What Determines Good Rehabilitation Recovery in Stroke Patients with very Severe Disability? A Retrospective Cohort Study[J].J Stroke Cerebrovasc Dis,2020,29(10):105130.[6]吴国豪.肠道屏障功能[J].肠外与肠内营养,2004,11(1):44-47.[7]Kurashima Y,Kiyono H.Mucosal ecological network of epithelium and immune cells for gut homeostasis and tissue healing[J].Annu Rev Immunol,2017,35:119-147.[8]Piton G,Manzon C,Cypriani B,et al.Acute intestinal failure in critically ill patients: is plasma citrulline the right marker?[J].Intensive Care Med,2011,37(6):911-917.[9]Arya AK,Hu B.Brain-gut axis after stroke[J].Brain Circ,2018,4(4):165-173. [10]Crapser J,Ritzel R,Verma R,et al.Ischemic stroke induces gut permeability and enhances bacterial translocation leading to sepsis in aged mice[J].Aging (Albany NY),2016,8(5):1049-1063.[11]Chen Y,Liang J,Ouyang F,et al.Persistence of Gut Microbiota Dysbiosis and Chronic Systemic Inflammation After Cerebral Infarction in Cynomolgus Monkeys[J].Front Neurol,2019,10:661.[12]Citi S.Intestinal barriers protect against disease[J].Science,2018,359(6380):1097-1098.[13]Stanley D,Mason LJ,Mackin KE,et al.Translocation and dissemination of commensal bacteria in post-stroke infection[J].Nat Med,2016,22(11):1277-1284.[14]Wen SW,Shim R,Ho L,et al.Advanced age promotes colonic dysfunction and gut-derived lung infection after stroke[J].Aging Cell,2019,18(5):e12980.[15]Piton G,Capellier G.Biomarkers of gut barrier failure in the ICU[J].Curr Opin Crit Care,2016,22(2):152-160.[16]中华医学会消化病学分会.肠屏障功能障碍临床诊治建议[J].中华消化杂志,2006,26(9):620.[17]Camara-Lemarroy CR,Escobedo-Zú?觡iga N,Guzmán-de la Garza FJ,et al.D-Lactate and intestinal fatty acid-binding protein are elevated in serum in patients with acute ischemic stroke[J].Acta Neurol Belg,2021,121(1):87-93.[18]Xue M,Ji X,Liang H,et al.The effect of fucoidan on intestinal flora and intestinal barrier function in rats with breast cancer[J].Food Funct,2018,9(2):1214-1223.[19]Guo Y,Li H,Liu Z,et al.Impaired intestinal barrier function in a mouse model of hyperuricemia[J].Mol Med Rep,2019,20(4):3292-3300. [20]Chen R,Wu P,Cai Z,et al.Puerariae Lobatae Radix with chuanxiong Rhizoma for treatment of cerebral ischemic stroke by remodeling gut microbiota to regulate the brain-gut barriers[J].J Nutr Biochem,2019,65:101-114.[21]丁春龙,王玉海,杨理坤,等.血清D-乳酸,细菌内毒素及二胺氧化酶在创伤性颅脑损伤后肠道黏膜屏障功能评估中的作用[J].中华神经外科杂志,2019,35(12):1258-1261.

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更新日期/Last Update: 1900-01-01