[1]熊鹏锋.沙库巴曲缬沙坦联合美托洛尔对青年扩张型心肌病患者心功能及预后的影响[J].医学信息,2022,35(20):80-83.[doi:10.3969/j.issn.1006-1959.2022.20.020]
　XIONG Peng-feng.Effect of Sacubitril Valsartan Combined with Metoprolol on Cardiac Function and Prognosis in Young Patients with Dilated Cardiomyopathy[J].Journal of Medical Information,2022,35(20):80-83.[doi:10.3969/j.issn.1006-1959.2022.20.020]
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沙库巴曲缬沙坦联合美托洛尔对青年扩张型心肌病患者心功能及预后的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年20期
页码:
80-83
栏目:
论著
出版日期:
2022-10-15

文章信息/Info

Title:
Effect of Sacubitril Valsartan Combined with Metoprolol on Cardiac Function and Prognosis in Young Patients with Dilated Cardiomyopathy
文章编号:
1006-1959（2022）20-0080-04
作者:
熊鹏锋
（丰城市人民医院心内二科，江西 丰城 331100）
Author(s):
XIONG Peng-feng
(The Second Department of Cardiology,Fengcheng People’s Hospital,Fengcheng 331100,Jiangxi,China)
关键词:
扩张型心肌病; 心功能; 沙库巴曲缬沙坦; 美托洛尔缓释片; 心血管不良事件
Keywords:
ilated cardiomyopathy; Cardiac function; Sacubitril valsartan; Metoprolol sustained release tablets; Cardiovascular adverse events
分类号:
R542.2
DOI:
10.3969/j.issn.1006-1959.2022.20.020
文献标志码:
A
摘要:
目的 研究沙库巴曲缬沙坦联合美托洛尔缓释片对青年扩张型心肌病（DCM）患者心功能及预后的影响。方法 选取2019年2月-2021年2月丰城市人民医院收治的78例青年DCM患者，采用随机数字表法分为对照组（美托洛尔缓释片治疗，39例）与观察组（沙库巴曲缬沙坦+美托洛尔缓释片治疗，39例），比较两组心功能指标[左心室舒张末期内径（LVEDV）、左心室收缩末期容积（LVESV）、左心室射血分数（LVEF）]、血清生化指标[肌钙蛋白激酶（CK）、肌钙蛋白激酶同工酶（CK-MB）、脑钠肽（BNP）]、不良反应及预后情况。结果 观察组治疗后LVEDV、LVESV低于对照组，LVEF高于对照组（P＜0.05）；观察组治疗后CK、CK-MB、BNP水平低于对照组（P＜0.05）；两组不良反应发生率比较，差异无统计学意义（P＞0.05）；观察组治疗后6个月MACE发生率及再次住院率均低于对照组（P＜0.05）。结论 沙库巴曲缬沙坦联合美托洛尔缓释片可改善青年DCM患者的心功能，缓解心肌损伤，降低MACE风险，改善预后，且不增加不良反应。
Abstract:
Objective To study the effect of sacubitril valsartan combined with metoprolol sustained-release tablets on cardiac function and prognosis in young patients with dilated cardiomyopathy (DCM).Methods A total of 78 young DCM patients admitted to Fengcheng People ’s Hospital of Jiangxi Province from February 2019 to February 2021 were selected and divided into control group (metoprolol sustained-release tablets, 39 cases) and observation group (sacubitril valsartan+metoprolol sustained-release tablets, 39 cases) by random number table method. Cardiac function indexes [left ventricular end-diastolic diameter (LVEDV), left ventricular end-systolic volume (LVESV), left ventricular ejection fraction (LVEF)], serum biochemical indexes [creatine kinase (CK), creatine kinase isoenzymes (CK-MB), brain natriuretic peptide (BNP)], adverse reactions and prognosis were compared between the two groups.Results After treatment, LVEDV and LVESV in the observation group were lower than those in the control group, and LVEF was higher than that in the control group (P<0.05). After treatment, the levels of CK, CK-MB and BNP in the observation group were lower than the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). The incidence of MACE and rehospitalization rate in the observation group were lower than those in the control group 6 months after treatment (P<0.05).Conclusion Sacubitril valsartan combined with metoprolol sustained-release tablets can significantly improve the cardiac function of young DCM patients, alleviate myocardial injury, reduce the risk of MACE, improve prognosis, and do not increase adverse reactions.

参考文献/References:

[1]张苒,李彬,李娜.沙库巴曲缬沙坦对扩张型心肌病并发慢性心力衰竭患者治疗效果及炎性因子的影响[J].临床误诊误治,2021,34(6):39-43.[2]Pinto YM,Elliott PM,Arbustini E,et al.Proposal for a revised definition of dilated cardiomyopathy, hypokinetic non-dilated cardiomyopathy, and its implications for clinical practice: a position statement of the ESC working group on myocardial and pericardial diseases[J].European Heart Journal,2016,37(23):1850-1858.[3]岑运光,廖卫,王太昊,等.葛酮通络胶囊联合缬沙坦沙库巴曲对扩张型心肌病心力衰竭患者心功能及血清sICAM-1、LPO水平的影响[J].现代中西医结合杂志,2020,29(20):2203-2207.[4]曾宪钦.琥珀酸美托洛尔缓释片与低分子肝素钠联合治疗扩张型心肌病心力衰竭[J].临床医学,2016,36(03):27-28.[5]陈亮波,陈雪松,徐晓红,等.沙库巴曲缬沙坦对青年扩张型心肌病患者左心室收缩失同步性的影响[J].中国医师进修杂志,2020,43(4):297-300.[6]李江,曹佳宁,刘文娴,等.沙库巴曲缬沙坦治疗老年人扩张型心肌病致慢性心力衰竭的疗效观察[J].中华老年医学杂志,2019,38(5):520-524.[7]中华医学会心血管病学分会,中国心肌炎心肌病协作组.中国扩张型心肌病诊断和治疗指南[J].临床心血管病杂志,2018,34(5):421-434.[8]Kim HM,Kim KH,Park JS,et al.Beneficial Effect of Left Ventricular Remodeling after Early Change of Sacubitril/Valsartan in Patients with Nonischemic Dilated Cardiomyopathy[J].Medicina (Kaunas),2021,57(5):416.[9]朱琳,邱雅慧.沙库巴曲缬沙坦对扩张型心肌病致慢性心力衰竭患者的疗效分析[J].中国医学工程,2021,29(6):69-72.[10]郝正阳,张彦周.小剂量沙库巴曲缬沙坦治疗90 mmHg≤收缩压＜100 mmHg的扩张型心肌病患者的有效性和安全性[J].中国心血管杂志,2021,26(3):253-256.[11]丁爱梅,曹帧,王向明,等.沙库巴曲缬沙坦治疗不同类型心肌病所致心力衰竭的效果观察[J].中国医院用药评价与分析,2021,21(10):1184-1187,1191.[12]Gramlich M,Pane LS,Zhou Q,et al.Antisense-mediated exon skipping: a therapeutic strategy for titin-based dilated cardiomyopathy[J].Embo Molecular Medicine,2015,7(5):562-576.[13]滕丽峰,林劲,黄玉冰.沙库巴曲缬沙坦钠片治疗扩张型心肌病效果观察[J].药物流行病学杂志,2020,29(8):525-528.[14]陈会校,李娟,柴巧英,等.沙库巴曲缬沙坦对老年扩张型心肌病继发慢性心力衰竭病人心脏功能及运动耐量的影响[J].中西医结合心脑血管病杂志,2020,18(24):4195-4197.[15]苏斌杰,俞飞虎,程劲松,等.沙库巴曲缬沙坦钠治疗扩张型心肌病临床疗效观察[J].心脑血管病防治,2019,19(6):570-572.[16]周政,刘高俊,刘超.美托洛尔治疗扩张型心肌病慢性心力衰竭的临床价值分析[J].分子诊断与治疗杂志,2020,12(11):1578-1581.[17]张娟,王吉利,谭月桂.曲美他嗪联合美托洛尔治疗老年扩张型心肌病合并心力衰竭患者的临床疗效[J].河北医药,2019,41(5):728-730,734.[18]蒲军亮,张婷.沙库巴曲缬沙坦钠片联合琥珀酸美托洛尔缓释片治疗慢性心力衰竭的疗效观察[J].医学信息,2020,33(14):159-160.[19]章体玲,张伟华,罗庆祎,等.沙库巴曲缬沙坦治疗扩张型心肌病心力衰竭的疗效[J].昆明医科大学学报,2020,41(3):91-95.[20]韩妹,熊璐,王萍,等.沙库巴曲缬沙坦联合美托洛尔对老年冠心病心力衰竭患者心功能及生活质量的影响[J].川北医学院学报,2021,36(8):1041-1044.[21]张丽娟,靳志涛,张铮,等.沙库巴曲缬沙坦联合美托洛尔治疗冠状动脉粥样硬化性心脏病合并心力衰竭临床评价[J].中国药业,2021,30(1):48-51.[22]张赟,许丽雯.缬沙坦联合美托洛尔治疗原发性高血压合并冠心病的疗效观察[J].中西医结合心脑血管病杂志,2016,14(2):173-175.[23]翟莉,吕俊刚,张琳,等.沙库巴曲缬沙坦在扩张型心肌病患者中的疗效观察[J].中国分子心脏病学杂志,2020,20(6):3602-3605.[24]李进,陈冬丽,何兴兵.缬沙坦联合美托洛尔对扩张型心肌病患者左心室重构及心功能的影响[J].解放军医药杂志,2018,30(12):45-47,56.[25]赵妙香,舒九伟.沙库巴曲缬沙坦钠与米力农联合依那普利对扩张型心肌病心力衰竭患者心功能及日常生活能力的影响[J].山西医药杂志,2020,49(15):2018-2020.

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更新日期/Last Update: 1900-01-01