[1]周晓玲,张嘉文,陈惠霞.2018-2020年某三甲医院肺炎克雷伯菌的分布情况及耐药现状分析[J].医学信息,2022,35(20):114-117.[doi:10.3969/j.issn.1006-1959.2022.20.030]
 ZHOU Xiao-ling,ZHANG Jia-wen,CHEN Hui-xia.Analysis of Distribution and Drug Resistance of Klebsiella Pneumoniae in A Tertiary Hospital from 2018 to 2020[J].Journal of Medical Information,2022,35(20):114-117.[doi:10.3969/j.issn.1006-1959.2022.20.030]
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2018-2020年某三甲医院肺炎克雷伯菌的分布情况及耐药现状分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年20期
页码:
114-117
栏目:
调查分析
出版日期:
2022-10-15

文章信息/Info

Title:
Analysis of Distribution and Drug Resistance of Klebsiella Pneumoniae in A Tertiary Hospital from 2018 to 2020
文章编号:
1006-1959(2022)20-0114-04
作者:
周晓玲张嘉文陈惠霞
(东莞市人民医院检验科,广东 东莞 523000)
Author(s):
ZHOU Xiao-lingZHANG Jia-wenCHEN Hui-xia
(Department of Clinical Laboratory,Dongguan People’s Hospital,Dongguan 523000,Guangdong,China)
关键词:
肺炎克雷伯菌病原学分布耐药性
Keywords:
Klebsiella pneumoniaePathogen distributionDrug resistance
分类号:
R378.99+6
DOI:
10.3969/j.issn.1006-1959.2022.20.030
文献标志码:
A
摘要:
目的 分析我院2018-2020年分离肺炎克雷伯菌分布情况及细菌耐药性特点。方法 收集2018-2020年我院检出肺炎克雷伯菌的病例信息,对肺炎克雷伯菌特点和耐药性进行回顾性分析。结果 2018-2019年我院临床检出肺炎克雷伯菌共1501株,平均分离率为10.09%,有823株来源于60岁以上的患者;从临床标本分布来看,主要分离自痰液(31.78%)、尿液(22.98%)、血液(17.79%)和分泌物(15.99%);从临床科室分布来看,分离率依次是ICU(13.59%)、神经外科(11.53%)、普外科(7.79%)和肿瘤内科(6.59%);2018-2020年我院肺炎克雷伯菌总体耐药情况呈缓慢上升趋势;耐药性方面,肺炎克雷伯菌对头孢唑林(30.10%)和头孢曲松(25.70%)耐药率较高,对头孢他啶(12.30%)、头孢吡肟(10.20%)和头孢替坦(2.50%)耐药率较低;对碳青霉烯类药物[亚胺培南(2.50%)、厄他培南(3.00%)]的耐药率相对较低;对环丙沙星(17.20%)、左氧氟沙星(13.90%)和庆大霉素(14.00%)的耐药率比阿米卡星(2.50%)、妥布霉素(5.20%)高;未检出对替加环素耐药的肺炎克雷伯菌。结论 我院分离的肺炎克雷伯菌临床分布广泛,耐药情况较严峻,呈缓慢上升趋势;应注重肺炎克雷伯菌的耐药性监测,预防医院感染的爆发和流行,合理使用抗菌药物,控制和减少耐药菌株的产生和传播。
Abstract:
Objective To analyze the distribution and drug resistance of Klebsiella pneumoniae isolated in our hospital from 2018 to 2020.Methods The case information of Klebsiella pneumoniae detected in our hospital from 2018 to 2020 was collected, and the characteristics and drug resistance of Klebsiella pneumoniae were analyzed retrospectively.Results A total of 1501 strains of Klebsiella pneumoniae were detected in our hospital from 2018 to 2019, with an average isolation rate of 10.09%. 823 strains were from patients over 60 years old. From the distribution of clinical specimens, it was mainly isolated from sputum (31.78%), urine (22.98%), blood (17.79%) and secretions (15.99%). From the distribution of clinical departments, the isolation rate was ICU (13.59%), neurosurgery (11.53%), general surgery (7.79%) and oncology (6.59%). From 2018 to 2020, the overall drug resistance of Klebsiella pneumoniae in our hospital showed a slow upward trend; in terms of drug resistance, the resistance rate of Klebsiella pneumoniae to cefazolin (30.10%) and ceftriaxone (25.70%) was higher, and to ceftazidime (12.30%), cefepime (10.20%) and cefotetan (2.50%) was lower. The resistance rates to carbapenems [imipenem (2.50%), ertapenem (3.00%)] were relatively low. The resistance rates to ciprofloxacin (17.20%), levofloxacin (13.90%) and gentamicin (14.00%) were higher than those to amikacin (2.50%) and tobramycin (5.20%). Klebsiella pneumoniae resistant to tigecycline was not detected.Conclusion The clinical distribution of Klebsiella pneumoniae isolated in our hospital is extensive, and the drug resistance is serious, showing a slow upward trend. It is necessary to pay attention to the monitoring of drug resistance of Klebsiella pneumoniae, prevent the outbreak and prevalence of nosocomial infection, rationally use antibiotics, and control and reduce the generation and spread of drug-resistant strains.

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更新日期/Last Update: 1900-01-01