[1]温书鑫.奥美拉唑三联疗法治疗慢性胃溃疡的疗效及对患者胃肠功能及Hp根除率的影响[J].医学信息,2022,35(20):136-138.[doi:10.3969/j.issn.1006-1959.2022.20.037]
　WEN Shu-xin.Effect of Omeprazole Triple Therapy on Gastrointestinal Function and Hp Eradication Rate in Patients with Chronic Gastric Ulcer[J].Journal of Medical Information,2022,35(20):136-138.[doi:10.3969/j.issn.1006-1959.2022.20.037]
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奥美拉唑三联疗法治疗慢性胃溃疡的疗效及对患者胃肠功能及Hp根除率的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年20期
页码:
136-138
栏目:
药物与临床
出版日期:
2022-10-15

文章信息/Info

Title:
Effect of Omeprazole Triple Therapy on Gastrointestinal Function and Hp Eradication Rate in Patients with Chronic Gastric Ulcer
文章编号:
1006-1959（2022）20-0136-03
作者:
温书鑫
（铅山县中医院消化内科，江西 铅山 334500）
Author(s):
WEN Shu-xin
(Department of Gastroenterology,Qianshan County Hospital of Traditional Chinese Medicine,Qianshan 334500,Jiangxi,China)
关键词:
慢性胃溃疡; 奥美拉唑; 三联疗法; 胃肠功能; Hp
Keywords:
Chronic gastric ulcer; Omeprazole; Triple therapy; Gastrointestinal function; Hp
分类号:
R573.1；R587.2
DOI:
10.3969/j.issn.1006-1959.2022.20.037
文献标志码:
A
摘要:
目的 观察慢性胃溃疡应用奥美拉唑三联疗法的治疗效果及对患者胃肠功能和Hp根除率的影响。方法 选取2018年1月-2020年1月我院收治的104例慢性胃溃疡患者为研究对象，采用随机数字表法分为对照组和观察组，各52例。对照组采用雷尼替丁三联疗法治疗，观察组采用奥美拉唑三联疗法治疗，比较两组治疗总有效率、Hp根除率、临床症状评分、胃功能指标以及临床不良反应发生率。结果 观察组治疗总有效率为96.15%，高于对照组的86.54%（P＜0.05）；观察组Hp根除率为94.23%，高于对照组的80.76%（P＜0.05）；观察组胃部灼烧感、反酸、嗳气评分均低于对照组（P＜0.05）；两组治疗后血清胃泌素（GCS）、胆囊收缩素（CKK）均低于治疗前，胃动素（MTL）高于治疗前，且观察组GCS、CKK低于对照组，MTL高于对照组（P＜0.05）；观察组不良反应发生率为5.77%，低于对照组的21.15%（P＜0.05）。结论 奥美拉唑三联疗法治疗慢性胃溃疡的疗效确切，可提高Hp根除率，改善胃功能指标，降低临床症状评分，且临床不良反应少，是一种安全、有效的治疗方法。
Abstract:
Objective To observe the effect of omeprazole triple therapy on gastrointestinal function and Hp eradication rate in patients with chronic gastric ulcer.Methods A total of 104 patients with chronic gastric ulcer admitted to our hospital from January 2018 to January 2020 were selected as the research objects. They were divided into control group and observation group by random number table method, with 52 cases in each group. The control group was treated with ranitidine triple therapy, and the observation group was treated with omeprazole triple therapy. The total effective rate, Hp eradication rate, clinical symptom score, gastric function index and incidence of clinical adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 96.15%, which was higher than 86.54% of the control group (P<0.05). The eradication rate of Hp in the observation group was 94.23%, which was higher than 80.76% in the control group (P<0.05). The scores of stomach burning, acid reflux and belching in the observation group were lower than those in the control group (P<0.05). After treatment, serum gastrin (GCS) and cholecystokinin (CKK) in the two groups were lower than those before treatment, and motilin (MTL) was higher than that before treatment, and GCS and CKK in the observation group were lower than those in the control group, MTL was higher than that in the control group (P<0.05). The incidence of adverse reactions in the observation group was 5.77%, which was lower than 21.15% in the control group (P<0.05).Conclusion Omeprazole triple therapy is effective in the treatment of chronic gastric ulcer, which can improve Hp eradication rate, improve gastric function index, reduce clinical symptom score, and has less clinical adverse reactions. It is a safe and effective treatment method.

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更新日期/Last Update: 1900-01-01