[1]陈晓东,乔阳波,周 伟.腹腔镜胆囊切除术治疗急性胆囊炎并发胆结石患者的效果[J].医学信息,2023,36(06):139-142.[doi:10.3969/j.issn.1006-1959.2023.06.030]
　CHEN Xiao-dong,QIAO Yang-bo,ZHOU Wei.Effect of Laparoscopic Cholecystectomy on Patients with Acute Cholecystitis Complicated with Gallstones[J].Journal of Medical Information,2023,36(06):139-142.[doi:10.3969/j.issn.1006-1959.2023.06.030]
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腹腔镜胆囊切除术治疗急性胆囊炎并发胆结石患者的效果()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年06期
页码:
139-142
栏目:
论著
出版日期:
2023-03-15

文章信息/Info

Title:
Effect of Laparoscopic Cholecystectomy on Patients with Acute Cholecystitis Complicated with Gallstones
文章编号:
1006-1959（2023）06-0139-04
作者:
陈晓东; 乔阳波; 周 伟
（天津市蓟州区中医医院外科，天津 301900）
Author(s):
CHEN Xiao-dong; QIAO Yang-bo; ZHOU Wei
(Department of Surgery,Jizhou District Hospital of Traditional Chinese Medicine,Tianjin 301900,China)
关键词:
急性胆囊炎; 胆结石; 炎症应激; 肝功能; 免疫功能
Keywords:
Acute cholecystitis; Gallstones; Inflammatory stress; Liver function; Immune function
分类号:
R657.4
DOI:
10.3969/j.issn.1006-1959.2023.06.030
文献标志码:
A
摘要:
目的 评价腹腔镜胆囊切除术（LC）治疗急性胆囊炎（AC）并发胆结石患者的预后效果。方法 以2019年11月-2021年11月天津市蓟州区中医医院收治的80例AC并发胆结石患者为研究对象，按照随机数字表法分为OC组（40例）与LC组（40例）。OC组行开腹胆囊切除术治疗，LC组行LC治疗，比较两组围术期指标（术中出血量、术后肛门排气时间、术后住院时间）、炎性应激指标[C反应蛋白（CRP）、白介素-6（IL-6）、淀粉酶（AMS）]、免疫功能（淋巴细胞亚群CD3+、CD4+）、肝功能[血清总胆红素（TBIL）、天冬氨酸转氨酶（AST）、丙氨酸转移酶（ALT）]、手术并发症发生情况。结果 LC组术中出血量少于OC组，且术后肛门排气时间、术后住院时间短于OC组（P＜0.05）；两组术后CRP、IL-6、AMS水平高于术前，但LC组低于OC组（P＜0.05）；两组术后CD3+、CD4+低于术前，但LC组高于OC组（P＜0.05）；两组术后TBIL、AST、ALT水平高于术前，但LC组低于OC组（P＜0.05）；LC组并发症发生率低于OC组（P＜0.05）。结论 LC在AC并发胆结石治疗中具有明显优势，其术中出血少、术后恢复快，可减轻机体炎症应激反应，降低手术对肝功能及免疫功能的影响，且术后并发症少。
Abstract:
Objective To evaluate the prognosis of laparoscopic cholecystectomy (LC) in patients with acute cholecystitis (AC) complicated with gallstones.Methods A total of 80 patients with AC complicated with gallstones admitted to Tianjin Jizhou District Hospital of Traditional Chinese Medicine from November 2019 to November 2021 were divided into OC group (40 cases) and LC group (40 cases) according to the random number table method. The OC group was treated with open cholecystectomy, and the LC group was treated with LC. The perioperative indicators (intraoperative blood loss, postoperative anal exhaust time, postoperative hospital stay), inflammatory stress indicators [C-reactive protein (CRP), interleukin-6 (IL-6), amylase (AMS)], immune function (lymphocyte subsets CD3+, CD4+), liver function [serum total bilirubin (TBIL), aspartate aminotransferase (AST), alanine aminotransferase (ALT)], and surgical complications were compared between the two groups.Results The intraoperative blood loss in LC group was less than that in OC group, and the postoperative anal exhaust time and postoperative hospital stay were shorter than those in OC group (P<0.05). The levels of CRP, IL-6 and AMS in the two groups after operation were higher than those before operation, but those in the LC group were lower than those in the OC group (P<0.05). The levels of CD3+ and CD4+ in the two groups after operation were lower than those before operation, but those in the LC group were higher than those in the OC group (P<0.05). The levels of TBIL, AST and ALT in the two groups after operation were higher than those before operation, but those in the LC group were lower than those in the OC group (P<0.05). The incidence of complications in LC group was lower than that in OC group (P<0.05).Conclusion LC has the advantages of less bleeding and rapid postoperative recovery in the treatment of AC complicated with gallstones. Meanwhile, it can reduce the inflammatory stress response of the body, reduce the impact of surgery on liver function and immune function, and have fewer postoperative complications.

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更新日期/Last Update: 1900-01-01