[1]李开双,罗茜怡,农志欢,等.鸡血藤活性成分及抗肿瘤作用研究[J].医学信息,2023,36(07):176-179,188.[doi:10.3969/j.issn.1006-1959.2023.07.036]
 LI Kai-shuang,LUO Xi-yi,NONG Zhi-huan,et al.Research Progress on Active Components and Anti-tumor Effects of Suberect Spatholobus Stem[J].Journal of Medical Information,2023,36(07):176-179,188.[doi:10.3969/j.issn.1006-1959.2023.07.036]
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鸡血藤活性成分及抗肿瘤作用研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年07期
页码:
176-179,188
栏目:
综述
出版日期:
2023-04-01

文章信息/Info

Title:
Research Progress on Active Components and Anti-tumor Effects of Suberect Spatholobus Stem
文章编号:
1006-1959(2023)07-0176-05
作者:
李开双罗茜怡农志欢
(1.广西中医药研究院药理所,广西 南宁 530022;2.桂林医学院药学院,广西 桂林 541000;3.广西壮族自治区人民医院药学部,广西 南宁 530000)
Author(s):
LI Kai-shuangLUO Xi-yiNONG Zhi-huanet al.
(1.Institute of Pharmacology,Guangxi Academy of Traditional Chinese Medicine,Nanning 530022,Guangxi,China; 2.College of Pharmacy,Guilin Medical University,Guilin 541000,Guangxi,China;3.Department of Pharmacy,the People’s Hospital of Guangxi Zhuang Auton
关键词:
鸡血藤提取工艺药理学抗肿瘤
Keywords:
Suberect spatholobus stemExtraction technologyPharmacologyAnti-tumor
分类号:
R282.71
DOI:
10.3969/j.issn.1006-1959.2023.07.036
文献标志码:
A
摘要:
鸡血藤含化学成分复杂,具有抗肿瘤活性成分,显现出良好的抗病毒、抗肿瘤作用,对抗肿瘤研究具有重要意义。本文就鸡血藤活性成分提取工艺及其抗宫颈癌、乳腺癌、肝癌、肺癌的药理作用和肿瘤细胞的相关死亡通道进行系统综述,以掌握鸡血藤活性成分提取工艺技术及抗肿瘤药理学研究进展,以此为鸡血藤药用资源的开发利用及为后续的抗肿瘤研究提供理论依据。
Abstract:
Suberect Spatholobus stem contains complex chemical components and has anti-tumor active ingredients, showing good antiviral and anti-tumor effects, which is of great significance for anti-tumor research. In this paper, the extraction technology of active components from suberect spatholobus stem and its pharmacological effects on cervical cancer, breast cancer, liver cancer, lung cancer and the related death channels of tumor cells are systematically reviewed, in order to master the extraction technology of active components from suberect spatholobus stem and the research progress of anti-tumor pharmacology, meanwhile to provide theoretical basis for the development and utilization of medicinal resources of suberect spatholobus stem and the subsequent anti-tumor research.

参考文献/References:

[1]程悦,符影,王志宇,等.鸡血藤提取物中缩合鞣质的含量测定及其抗肿瘤活性初步研究[J].中山大学学报(自然科学版),2011,50(2):75-80.[2]金晨,黄慧莲,何玉琴,等.丰城鸡血藤的化学成分[J].中国药科大学学报,2021,52(2):177-185.[3]庞佶,郭金鹏,金敏,等.鸡血藤水提取物的体内抗coxsackievirus B3病毒作用[J].中国卫生检验杂志,2014,24(13):1863-1865.[4]庞佶,郭金鹏,金敏,等.鸡血藤水提物抗流感病毒作用的研究[J].中国卫生检验杂志,2015,25(4):488-490,493.[5]赵梦利,刘妍如,宋忠兴,等.基于成分-抗氧化活性相关的鸡血藤饮片等级评价研究[J].中草药,2020,51(4):943-949.[6]卢识礼,吴柏毅,肖宗崇,等.鸡血藤醇提物对高脂血症大鼠血脂及抗脂质过氧化作用的影响[J].广州中医药大学学报,2017,34(3):387-390.[7]杨培树,顾学宁,安雅婷,等.当归等中药水提物体外抗氧化应激及抗炎作用研究[J].中国城乡企业卫生,2018,33(4):71-72.[8]张浩,申玉清.鸡血藤醇提物对血虚模型小鼠的补血作用[J].中国药房,2014,25(3):221-223.[9]杨冉,林琳,姚浩,等.基于数据挖掘的慢性原发免疫性血小板减少症用药规律分析[J].中国中医药基础医学杂志,2020,26(3):350-353.[10]梁宁,韦松基,林启云.鸡血藤总黄酮对血虚小鼠抗贫血作用及机理研究[J].时珍国医国药,2009,20(2):362-363.[11]刘钰萍,贾雷,张锋,等.不同来源鸡血藤化学特征与抗肿瘤作用差异研究[J].中药药理与临床,2020,36(2):136-140.[12]张爱文,何彩美,钟晶,等.鸡血藤提取物的制备及药理毒理研究[J].中兽医医药杂志,2011,30(3):20-22.[13]刘晓艳,徐嵬,杨秀伟,等.鸡血藤黄酮类化学成分的分离与鉴定[J].中国中药杂志,2020,45(6):1384-1392.[14]黄福荣,张明,陈珍.正交试验优选云南鸡血藤的水提取工艺研究[J].科技视界,2013(6):169,180.[15]王妮佳,王嘉仡,孟宪生,等.基于3D微流控芯片分析鸡血藤总鞣质对宫颈癌细胞HeLa的药理作用[J].中国实验方剂学杂志,2019,25(2):103-108.[16]姜洋,刘青青,张峰,等.鸡血藤通过调控SNX9及 -catenin抑制三阴性乳腺癌细胞转移的作用机制[J].中国中西医结合杂志,2020,40(11):1356-1359.[17]王兰英,孙吉利,苏家茹.鸡血藤总黄酮对人乳腺癌细胞株MCF-7增殖凋亡的影响及对Wnt/β-catenin通路的调控作用[J].中医学报,2021,36(7):1512-1518.[18]廖健明,秦祖杰,杨秋雨,等.基于网络药理学鸡血藤治疗肝细胞癌的作用机制研究[J].广西医学,2020,42(14):1840-1845.[19]陈康,金晨,程玉瑶,等.基于网络药理学和分子对接探讨鸡血藤治疗肺癌的分子作用机制[J].中国中药杂志,2021,46(4):837-844.[20]So T,Ishii N.The TNF-TNFR Family of Co-signal Molecules[J].Adv Exp Med Biol,2019,1189:53-84.[21]Wei LQ,Xu CF,Li WT,et al.NF-κB and MAPK signaling path ways are involved in the apoptosis of breast cancer MDA-MB-231 cells induced by genistein[J].Chin Pharmacol Bull,2018,34(5):690-694.[22]Wu SJ,Sa RN,Gu ZR,et al.Horse chestnut seed extract protects acute liver injury induced by concanavalin A by inhibiting reactive oxygen species and JNK pathway[J].Chin Pharmacol Bull,2018,34(3):412-418.[23]Xu Y,Lin Z,Zhao N,et al.Receptor interactive protein kinase 3 promotes Cisplatin-triggered necrosis in apoptosis-resistant esophageal squamous cell carcinoma cells[J].PLoS One,2014,9(6):e100127.[24]郭旗.促细胞凋亡方法的建立[J].当代化工研究,2018(8):198-200.[25]Fallahi E,O’Driscoll NA,Matallanas D.The MST/Hippo Pathway and Cell Death: A Non-Canonical Affair[J].Genes (Basel),2016,7(6):28.[26]Tan T,Lu B,Zhang J,et al.Notch1 signaling antagonizes transforming growth factor-β pathway and induces apoptosis in rabbit trophoblast stem cells[J].Stem Cells Dev,2014,23(8):813-822.[27]李欣,杨作成.mTOR信号通路与细胞凋亡[J].国际免疫学杂志,2013,36(5):337-340.[28]Li X,Wu H,Ouyang X,et al.New bioactive peptide reduces the toxicity of chemotherapy drugs and increases drug sensitivity[J].Oncol Rep,2017,38(1):129-140.[29]Fang Y,Tian S,Pan Y,et al.Pyroptosis:a new frontier in cancer[J].Biomed Pharmacother,2020,121:109595.[30]黄珊,赵漫玉,张佩景.铁死亡调控机理及其在肿瘤治疗中的应用[J].科技导报,2021,39(7):63-74.

更新日期/Last Update: 1900-01-01