[1]王翠静,朱艳红,刘凤芝.小剂量阿司匹林联合硝苯地平对妊娠期高血压患者血压水平及凝血功能的影响[J].医学信息,2023,36(10):138-141.[doi:10.3969/j.issn.1006-1959.2023.10.030]
　WANG Cui-jing,ZHU Yan-hong,LIU Feng-zhi.Effect of Low-dose Aspirin Combined with Nifedipine on Blood Pressure Level and Coagulation Function in Patients with Pregnancy-induced Hypertension[J].Journal of Medical Information,2023,36(10):138-141.[doi:10.3969/j.issn.1006-1959.2023.10.030]
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小剂量阿司匹林联合硝苯地平对妊娠期高血压患者血压水平及凝血功能的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年10期
页码:
138-141
栏目:
论著
出版日期:
2023-05-15

文章信息/Info

Title:
Effect of Low-dose Aspirin Combined with Nifedipine on Blood Pressure Level and Coagulation Function in Patients with Pregnancy-induced Hypertension
文章编号:
1006-1959（2023）10-0138-04
作者:
王翠静; 朱艳红; 刘凤芝
（天津市蓟州区中医医院产科，天津 301900）
Author(s):
WANG Cui-jing; ZHU Yan-hong; LIU Feng-zhi
(Department of Obstetrics and Gynecology,Jizhou District Traditional Chinese Medicine Hospital,Tianjin 301900,China)
关键词:
妊娠期高血压; 阿司匹林; 硝苯地平; 凝血功能; 血压
Keywords:
Pregnancy-induced hypertension; Aspirin; Nifedipine; Coagulation function; Blood pressure
分类号:
R714.24+6
DOI:
10.3969/j.issn.1006-1959.2023.10.030
文献标志码:
A
摘要:
目的 研究小剂量阿司匹林联合硝苯地平对妊娠期高血压（PIH）患者血压水平及凝血功能的影响。方法 选取2020年3月-2022年3月天津市蓟州区中医医院收治的60例PIH患者，按照随机数字表法分为对照组（30例）与观察组（30例）。对照组给予硝苯地平治疗，观察组给予小剂量阿司匹林联合硝苯地平治疗，比较两组临床疗效、血压水平[收缩压（SBP）、舒张压（DBP）]、凝血功能[凝血酶原时间（PT）、活化凝血酶原时间（APTT）、纤维蛋白原（Fib）]、不良反应、妊娠结局。结果 观察组治疗有效率高于对照组（P＜0.05）；观察组治疗后SBP、DBP水平低于对照组（P＜0.05）；观察组治疗后PT、APTT高于对照组，Fib低于对照组（P＜0.05）；两组不良反应发生率比较，差异无统计学意义（P＞0.05）；观察组不良妊娠结局发生率低于对照组（P＜0.05）。结论 小剂量阿司匹林联合硝苯地平治疗PIH的效果确切，其降压作用理想，可改善患者凝血功能，降低其不良妊娠结局风险，且不良反应少。
Abstract:
Objective To study the effect of low-dose aspirin combined with nifedipine on blood pressure and coagulation function in patients with pregnancy-induced hypertension (PIH).Methods Sixty patients with PIH admitted to Tianjin Jizhou District Hospital of Traditional Chinese Medicine from March 2020 to March 2022 were selected and divided into control group (30 patients) and observation group (30 patients) according to the random number table method. The control group was treated with nifedipine, and the observation group was treated with low-dose aspirin combined with nifedipine. The clinical efficacy, blood pressure level [systolic blood pressure (SBP), diastolic blood pressure (DBP)], coagulation function [prothrombin time (PT), activated prothrombin time (APTT), fibrinogen (Fib)], adverse reactions and pregnancy outcome were compared between the two groups.Results The effective rate of treatment in the observation group was higher than that in the control group (P<0.05). After treatment, the levels of SBP and DBP in the observation group were lower than those in the control group (P<0.05). After treatment, PT and APTT in the observation group were higher than those in the control group, and Fib was lower than that in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05). The incidence of adverse pregnancy outcomes in the observation group was lower than that in the control group (P<0.05).Conclusion Low-dose aspirin combined with nifedipine is effective in the treatment of PIH, and its antihypertensive effect is ideal. It can improve the coagulation function of patients, reduce the risk of adverse pregnancy outcomes, and has fewer adverse reactions.

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更新日期/Last Update: 1900-01-01