[1]孙鹏飞,王华东.前列疏通汤联合非那雄胺治疗良性前列腺增生的临床疗效及对前列腺特异性抗原的影响[J].医学信息,2023,36(14):133-136.[doi:10.3969/j.issn.1006-1959.2023.14.027]
　SUN Peng-fei,WANG Hua-dong.Clinical Effect of Qianlie Shutong Decoction Combined with Finasteride in the Treatment of Benign Prostatic Hyperplasia and its Effect on Prostate Specific Antigen[J].Journal of Medical Information,2023,36(14):133-136.[doi:10.3969/j.issn.1006-1959.2023.14.027]
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前列疏通汤联合非那雄胺治疗良性前列腺增生的临床疗效及对前列腺特异性抗原的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年14期
页码:
133-136
栏目:
论著
出版日期:
2023-07-15

文章信息/Info

Title:
Clinical Effect of Qianlie Shutong Decoction Combined with Finasteride in the Treatment of Benign Prostatic Hyperplasia and its Effect on Prostate Specific Antigen
文章编号:
1006-1959（2023）14-0133-04
作者:
孙鹏飞; 王华东
（天津市宝坻区人民医院泌尿外科，天津 301800）
Author(s):
SUN Peng-fei; WANG Hua-dong
(Department of Urology,Baodi District People’s Hospital,Tianjin 301800,China)
关键词:
良性前列腺增生; 前列疏通汤; 非那雄胺; 前列腺特异性抗原; 尿流动力学
Keywords:
Benign prostatic hyperplasia; Qianlie Shutong decoction; Finasteride; Prostate specific antigen; Urodynamic
分类号:
R277.5
DOI:
10.3969/j.issn.1006-1959.2023.14.027
文献标志码:
A
摘要:
目的 分析前列疏通汤联合非那雄胺治疗良性前列腺增生（BPH）的临床疗效及对前列腺特异性抗原（PSA）的影响。方法 以2021年3月-2022年3月天津市宝坻区人民医院泌尿外科收治的80例BPH患者为研究对象，按照随机数字表法分为对照组（40例）与观察组（40例）。对照组给予非那雄胺治疗，观察组在此基础上联合前列疏通汤治疗，比较两组临床疗效、前列腺体积、血清PSA水平、尿动力学水平[排尿总量、最大尿流率（MFR）、平均尿流率（AFR）]、国际前列腺症状评分（I-PSS）、生活质量量表评分（QOL）及不良反应。结果 观察组治疗总有效率高于对照组（P＜0.05）；两组治疗后前列腺体积、PSA水平小于治疗前，且观察组前列腺体积、PSA水平小于对照组（P＜0.05）；两组治疗后排尿总量、MFR、AFR均大于治疗前，且观察组排尿总量、MFR、AFR均大于对照组（P＜0.05）；两组治疗后I-PSS评分低于治疗前，QOL评分高于治疗前，且观察组I-PSS评分低于对照组，QOL评分高于对照组（P＜0.05）；两组不良反应发生率比较，差异无统计学意义（P＞0.05）。结论 前列疏通汤联合非那雄胺在BPH治疗中疗效确切，可缩小患者前列腺体积，降低其血清PSA水平，改善尿流动力学水平，促使症状缓解，提高生活质量，用药安全性良好。
Abstract:
Objective To analyze the clinical efficacy of Qianlie Shutong decoction combined with finasteride in the treatment of benign prostatic hyperplasia (BPH) and its effect on prostate specific antigen (PSA).Methods A total of 80 patients with BPH admitted to the Department of Urology, Tianjin Baodi District People’s Hospital from March 2021 to March 2022 were divided into control group (40 patients) and observation group (40 patients) according to the random number table method. The control group was treated with finasteride, and the observation group was treated with Qianlie Shutong decoction on this basis. The clinical efficacy, prostate volume, serum PSA level, urodynamic level [total urination, maximum urinary flow rate (MFR), average urinary flow rate (AFR)], international prostate symptom score (I-PSS), quality of life scale score (QOL) and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group (P<0.05). The prostate volume and PSA level of the two groups after treatment were less than those before treatment, and the prostate volume and PSA level of the observation group were less than those of the control group (P<0.05). After treatment, the total amount of urination, MFR and AFR in the two groups were higher than those before treatment, and the total amount of urination, MFR and AFR in the observation group were higher than those in the control group (P<0.05). After treatment, the I-PSS score of the two groups was lower than that before treatment, and the QOL score was higher than that before treatment, while the I-PSS score of the observation group was lower than that of the control group, and the QOL score was higher than that of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion Qianlie Shutong decoction combined with finasteride is effective in the treatment of BPH, which can reduce the volume of prostate, reduce the level of serum PSA, improve the level of urodynamics, promote the relief of symptoms, improve the quality of life, and has good safety.

参考文献/References:

[1]杨非衡,许磊,陈凯.爱普列特在良性前列腺增生疾病治疗的有效性及对前列腺特异性抗原的影响[J].贵州医药,2018,42(4):447-448.[2]Lim KB.Epidemiology of clinical benign prostatic hyperplasia[J].Asian Journal of Urology,2017,4(3):148-151.[3]段刘剑,钱苏波.前列腺增生患者应用非那雄胺治疗前后前列腺移行带体积变化的临床意义[J].现代泌尿外科杂志,2021,26(10):831-835.[4]邓广鹏,万跃平.非那雄胺联合经尿道前列腺等离子电切术治疗前列腺增生的疗效及对患者生活质量的影响[J].广西医科大学学报,2017,34(7):1091-1093.[5]王祖龙,陈如兵,赵盼盼,等.扶正化积癃闭汤治疗良性前列腺增生症逼尿肌收缩功能障碍的临床观察[J].中国中医基础医学杂志,2020,26(6):808-811.[6]张治国,刘洪盛.前列通瘀汤对前列腺增生模型大鼠组织蛋白激酶调控及抑制前列腺增生机制影响[J].四川中医,2018,36(11):41-44.[7]于文晓.良性前列腺增生症中西医结合多学科诊疗指南（2022版）[J].中国男科学杂志,2022,36(2):96-102.[8]马怀霞.清肺饮加味联合非那雄胺对肺热壅盛证前列腺增生患者尿流动力学及生活质量的影响[J].四川中医,2017,35(7):157-159.[9]黄翔,蔡海荣,施思.中西医结合治疗良性前列腺增生症的临床观察[J].中华中医药学刊,2017,35(8):2196-2198.[10]梁剑梅,赵冠耀,罗健玲,等.前列舒通胶囊联合非那雄胺治疗良性前列腺增生症的临床研究[J].中国性科学,2018,27(4):13-15.[11]游旭军,李其信,傅伟,等.通癃启闭汤对良性前列腺增生症患者血清性激素水平及IPSS和IIEF-5评分的影响[J].广州中医药大学学报,2018,35(3):402-407.[12]殷波,杨勇,孙菊元.非那雄胺与多沙唑嗪联合应用对老年良性前列腺增生夜尿症状的影响[J].解放军预防医学杂志,2017,35(7):793-795.[13]王春仙,宫香宇,张素英,等.前列欣联合盐酸坦索罗辛和非那雄胺治疗老年良性前列腺增生的疗效观察[J].中国药房,2017,28(8):1108-1111.[14]吴钟彪,房华.前列通窍汤治疗良性前列腺增生合并前列腺炎的疗效观察[J].中医药导报,2017,23(23):93-95.[15]严丰,杨凯.自拟通癃软结汤治疗良性前列腺增生的临床研究[J].中医药导报,2018,24(2):93-95.[16]陈化磊,卓小岸,车宪平,等.活血化瘀方联合西医治疗前列腺增生症疗效及对血浆内皮素的影响[J].现代中西医结合杂志,2017,26(21):2287-2289,2292.[17]邵文光,王建忠,姜雷.前列舒通联合非那雄胺对良性前列腺增生术后患者血管内皮生长因子、热休克蛋白、前列腺特异抗原及性激素的影响分析[J].中国性科学,2022,31(5):37-41.[18]杨志,王莹.夏荔芪胶囊联合非那雄胺治疗良性前列腺增生症的临床研究[J].现代药物与临床,2019,34(10):3071-3075.[19]田子阳,冯伟,朱元全,等.前列舒通胶囊联合非那雄胺对良性前列腺增生症的疗效观察[J].西部医学,2018,30(2):224-227.[20]韩兵,刘兵.前列疏通汤联合非那雄胺治疗良性前列腺增生的临床疗效及对前列腺特异性抗原的影响[J].医学综述,2020,26(10):2047-2051.[21]陈立华,吴广,周恒毅.前列疏通汤、非那雄胺联合治疗对良性前列腺增生患者下尿路症状及国际前列腺症状评分的影响[J].实用医院临床杂志,2022,19(4):178-180.

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更新日期/Last Update: 1900-01-01