[1]罗之彦,刘小虹,江 勇.基于网络药理学研究黄芩-桑白皮药对治疗支气管扩张咯血的作用机制[J].医学信息,2023,36(16):21-26.[doi:10.3969/j.issn.1006-1959.2023.16.004]
　LUO Zhi-yan,LIU Xiao-hong,JIANG Yong.Mechanism of Scutellaria Baicalensis-Cortex Mori in the Treatment of Bronchiectasis with Hemoptysis Based on Network Pharmacology[J].Journal of Medical Information,2023,36(16):21-26.[doi:10.3969/j.issn.1006-1959.2023.16.004]
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基于网络药理学研究黄芩-桑白皮药对治疗支气管扩张咯血的作用机制()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年16期
页码:
21-26
栏目:
中医药信息学
出版日期:
2023-08-15

文章信息/Info

Title:
Mechanism of Scutellaria Baicalensis-Cortex Mori in the Treatment of Bronchiectasis with Hemoptysis Based on Network Pharmacology
文章编号:
1006-1959（2023）16-0021-06
作者:
罗之彦; 刘小虹; 江 勇
（1.深圳市中西医结合医院肺病科，广东 深圳 518104；2.广州中医药大学第一附属医院呼吸与危重症医学科，广东 广州 510405）
Author(s):
LUO Zhi-yan; LIU Xiao-hong; JIANG Yong
(1.Department of Respiratory,Shenzhen Hospital of Integrated Traditional and Western Medicine,Shenzhen 518104,Guangdong,China;2.Department of Respiratory and Critical Care Medicine,the First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,Guangdong,China)
关键词:
支气管扩张; 咯血; 黄芩; 桑白皮; 网络药理学
Keywords:
Bronchiectasis; Hemoptysis; Scutellaria baicalensis; Cortex mori; Network pharmacology
分类号:
R259
DOI:
10.3969/j.issn.1006-1959.2023.16.004
文献标志码:
A
摘要:
目的 基于网络药理学分析黄芩-桑白皮药对治疗支气管扩张咯血的有效活性成分、作用靶点和作用通路，并探讨其作用机制。方法 通过中药系统药理学数据库与分析平台（TCMSP）、Uniprot数据库筛选黄芩-桑白皮药对的有效活性成分和作用靶点。在GeneCards、OMIM数据库检索支气管扩张咯血的疾病靶点。利用在线作图平台绘制韦恩图，获得黄芩-桑白皮与支气管扩张咯血的共同靶点。使用Cytoscape软件建立“药物-活性成分-靶点-疾病”网络图。以String平台数据为基础，利用Cytoscape软件构建交集靶点的蛋白相互作用网络，筛选关键作用靶点。通过Metascape数据库对交集靶点进行GO功能和KEGG通路富集分析。结果 共筛选得到黄芩-桑白皮治疗支气管扩张咯血的有效活性成分61个，潜在作用靶点101个，关键作用靶点涉及肿瘤坏死因子（TNF）、白细胞介素-6（IL-6）、VEGFA、白细胞介素-1β（IL-1β）、CASP3、MMP-9等，发现AGE-RAGE、TNF、白细胞介素-17（IL17）等信号通路在黄芩-桑白皮治疗支气管扩张咯血中起到较为关键的作用。结论 黄芩-桑白皮治疗支气管扩张咯血是通过多成分、多靶点、多通路的过程实现的，为进一步明确该药对治疗支气管扩张咯血的作用机制提供了生物信息学基础。
Abstract:
Objective To analyze the active components, targets and pathways of scutellaria baicalensis-cortex mori in the treatment of bronchiectasis with hemoptysis based on network pharmacology, and to explore its mechanism.Methods The active components and relevant targets of the herb pairs were screened by using Traditional Chinese Medicines Systems Pharmacology Platform (TCMSP) and Uniprot database. The target genes related to bronchiectasis with hemoptysis were obtained from GeneCards and OMIM databases. Draw Venn diagram of the two targets genes to retrive intersection targets. Cytoscape software was used to establish a "drug-active ingredient-target-disease" network diagram. Based on the data of String platform, Cytoscape software was used to construct the protein interaction network of intersection targets and screen the key targets. The GO function and KEGG pathway enrichment analysis of the intersection targets were performed by Metascape database.Results A total of 61 active components and 101 potential action targets were screened out for scutellaria baicalensis-cortex mori in the treatment of bronchiectasis with hemoptysis. The key targets involved tumor necrosis factor (TNF), interleukin-6 (IL-6), VEGFA, interleukin-1β (IL-1β), CASP3, MMP-9, etc, and it was found that signaling pathways such as AGE-RAGE, TNF, and interleukin-17 (IL17) played a key role in the treatment of bronchiectasis hemoptysis by scutellaria baicalensis-cortex mori.Conclusion The treatment of bronchiectasis with hemoptysis with scutellaria baicalensis-cortex mori is achieved through a combined action of multiple components, multiple pathways and multiple targets, which has provided a biological information basis for deeply specifying the mechanism.

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更新日期/Last Update: 1900-01-01