[1]见永康,吴泽俊,庄雅丽.宫颈癌筛查联合阴道镜活检防治宫颈癌前病变的价值研究[J].医学信息,2023,36(16):117-120.[doi:10.3969/j.issn.1006-1959.2023.16.022]
　JIAN Yong-kang,WU Ze-jun,ZHUANG Ya-li.Study on the Value of Cervical Cancer Screening Combined with Colposcopy Biopsy in the Prevention and Treatment of Cervical Precancerous Lesions[J].Journal of Medical Information,2023,36(16):117-120.[doi:10.3969/j.issn.1006-1959.2023.16.022]
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宫颈癌筛查联合阴道镜活检防治宫颈癌前病变的价值研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年16期
页码:
117-120
栏目:
论著
出版日期:
2023-08-15

文章信息/Info

Title:
Study on the Value of Cervical Cancer Screening Combined with Colposcopy Biopsy in the Prevention and Treatment of Cervical Precancerous Lesions
文章编号:
1006-1959（2023）16-0117-04
作者:
见永康; 吴泽俊; 庄雅丽
（安徽医科大学附属妇幼保健院综合妇科，安徽 合肥 230000）
Author(s):
JIAN Yong-kang; WU Ze-jun; ZHUANG Ya-li
(Department of Comprehensive Gynecology,Maternal and Child Health Hospital Affiliated to Anhui Medical University,Hefei 230000,Anhui,China)
关键词:
TCT; HPV; 阴道镜; 宫颈癌前病变; 宫颈癌
Keywords:
TCT; HPV; Colposcopy; cervical precancerous lesions; Cervical cancer
分类号:
R737.33
DOI:
10.3969/j.issn.1006-1959.2023.16.022
文献标志码:
A
摘要:
目的 探究在宫颈癌前病变防治过程中，液基细胞学检测（TCT）、人乳头状瘤病毒（HPV）DNA检测和阴道镜检查三种方法的应用价值。方法 选取安徽医科大学附属妇幼保健院2021年1月-2022年1月收治的542例疑似子宫颈癌前病变患者为研究对象，所有患者在诊断过程中均接受液基细胞学检查和HPV DNA检测并对二者中任一结果为阳性的患者行阴道镜活检，比较单独诊断与联合诊断的灵敏度、特异度、阴性预测值、阳性预测值、准确度，分析其诊断效能。结果 542例疑似宫颈病变患者中，TCT筛查阳性320例（59.04%），HPV筛查阳性487例（89.85%），TCT联合HPV检测共检出阳性患者537例（99.07%）；TCT联合HPV检测在宫颈癌前病变及宫颈癌诊断中的特异度、阳性预测值、准确度高于两者单独检测，而灵敏度低于两者单独检测，差异有统计学意义（P＜0.05）。随着宫颈活检病理级别的升高，TCT在炎症、CINⅠ、CINⅡ、CINⅢ、SCC患者的阳性率分别为43.18%、68.89%、77.28%、86.96%、100.00%，呈升高趋势；高危型HPV DNA检测的阳性率也大致与宫颈活检病理级别呈正相关，分别为86.36%、91.11%、97.72%、97.82%、87.50%，差异有统计学意义（P＜0.05）。结论 TCT、HPV DNA检测联合阴道镜检查能够提高宫颈癌筛查的特异性和准确度，有利于早期发现宫颈病变。
Abstract:
Objective To explore the effect of thinprep cytologic test (TCT), human papillomavirus (HPV) DNA test combined with colposcopy biopsy in the prevention and treatment of cervical precancerous lesions.Methods A total of 542 patients with suspected cervical precancerous lesions from January 2021 to January 2022 in the Maternal and Child Health Hospital of Anhui Medical University were selected as the research objects. All patients underwent Thinprep cytologic test and HPV DNA test during the diagnosis process, and colposcopy biopsy was performed on patients with positive results in either of the two. The sensitivity, specificity, negative predictive value, positive predictive value and accuracy of single diagnosis and combined diagnosis were compared, and their diagnostic efficacy was analyzed.Results Among the 542 patients with suspected cervical lesions, 320 patients (59.04%) were positive by TCT test, 487 patients (89.85%) were positive by HPV test, and 537 patients (99.07%) were positive by TCT combined with HPV test. The specificity, positive predictive value and accuracy of the diagnosis of cervical precancerous lesions and cervical cancer by TCT combined with HPV test were higher than those of the two separate tests, while the sensitivity was lower than that of the two separate tests, and the difference was statistically significant (P<0.05). With the increase of pathological grade of cervical biopsy, the positive rates of TCT in patients with inflammation, CINI, CINII, CINIII and SCC were 43.18%, 68.89%, 77.28%, 86.96% and 100.00%, respectively, showing an increasing trend. The positive rate of high-risk HPV DNA test was also positively correlated with the pathological grade of cervical biopsy, which was 86.36%, 91.11%, 97.72%, 97.82% and 87.50%, respectively, and the difference was statistically significant (P<0.05).Conclusion TCT, HPV DNA test combined with colposcopy can improve the specificity and accuracy of cervical cancer screening, which is conducive to the early detection of cervical lesions.

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更新日期/Last Update: 1900-01-01