[1]陈玉梅,陈彩云,马 震,等.NRF2信号通路在卵巢癌中的研究[J].医学信息,2023,36(16):179-183.[doi:10.3969/j.issn.1006-1959.2023.16.037]
 CHEN Yu-mei,CHEN Cai-yun,MA Zhen,et al.Research Progress on the Role of NRF2 Signaling Pathway in Ovarian Cancer[J].Journal of Medical Information,2023,36(16):179-183.[doi:10.3969/j.issn.1006-1959.2023.16.037]
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NRF2信号通路在卵巢癌中的研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年16期
页码:
179-183
栏目:
综述
出版日期:
2023-08-15

文章信息/Info

Title:
Research Progress on the Role of NRF2 Signaling Pathway in Ovarian Cancer
文章编号:
1006-1959(2023)16-0179-05
作者:
陈玉梅陈彩云马 震
(1.广东医科大学第一临床医学院,广东 湛江 524000;2.广东医科大学附属医院妇产科,广东 湛江 524000)
Author(s):
CHEN Yu-meiCHEN Cai-yunMA Zhenet al.
(1.The First Clinical Medical College of Guangdong Medical University,Zhanjiang 524000,Guangdong,China; 2.Department of Obstetrics and Gynecology,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524000,Guangdong,China)
关键词:
核因子E2相关因子卵巢癌活性氧氧化应激
Keywords:
Nuclear factor E2 related factorOvarian cancerReactive oxidative speciesOxidative stress
分类号:
R737.31
DOI:
10.3969/j.issn.1006-1959.2023.16.037
文献标志码:
A
摘要:
卵巢癌(OC)是女性生殖系统最常见的恶性肿瘤之一,由于化疗耐药的发生,致死率高,且易复发,严重威胁女性健康。核因子E2相关因子(NRF2)是一种重要的转录因子,在防止活性氧(ROS)等介导的氧化应激损伤方面发挥着关键作用。然而,癌细胞中NRF2激活是导致化疗耐药性发生发展的原因,使药物介导的氧化应激失活,而氧化应激通常导致癌细胞死亡。本文主要综述了NRF2在卵巢癌中的作用关系,总结NRF2在卵巢癌常见化疗药物耐药中的作用,旨在阐明NRF2、氧化应激与卵巢癌之间关系的研究,经典的NRF2抑制剂及其化合物在卵巢癌的防治中可能起到的重要作用。
Abstract:
Ovarian cancer (OC) is one of the most common malignant tumors in the female reproductive system tumors. Due to the occurrence of chemotherapy resistance, the mortality rate is high, and it is easy to relapse, which seriously threatens women’s health. Nuclear factor E2 related factor (NRF2) is an important transcription factor, which plays a key role in preventing oxidative stress injury mediated by reactive oxygen species (ROS). However, NRF2 activation in cancer cells is the cause of the occurrence and development of chemotherapy resistance, which inactivates drug-mediated oxidative stress, which usually leads to cancer cell death. This article mainly reviews the role of NRF2 in ovarian cancer and summarizes the role of NRF2 in the resistance of common chemotherapeutic drugs in ovarian cancer. It aims to clarify the relationship between NRF2, oxidative stress and ovarian cancer, and the classic NRF2 inhibitors and their compounds may play an important role in the prevention and treatment of ovarian cancer.

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更新日期/Last Update: 1900-01-01