[1]王 芳.右美托咪定对腹腔镜肝切除术老年患者脑氧饱和度及血流动力学的影响[J].医学信息,2023,36(22):116-119.[doi:10.3969/j.issn.1006-1959.2023.22.026]
　WANG Fang.Effects of Dexmedetomidine on Cerebral Oxygen Saturation and Hemodynamics in Elderly Patients Undergoing Laparoscopic Hepatectomy[J].Journal of Medical Information,2023,36(22):116-119.[doi:10.3969/j.issn.1006-1959.2023.22.026]
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右美托咪定对腹腔镜肝切除术老年患者脑氧饱和度及血流动力学的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年22期
页码:
116-119
栏目:
论著
出版日期:
2023-11-15

文章信息/Info

Title:
Effects of Dexmedetomidine on Cerebral Oxygen Saturation and Hemodynamics in Elderly Patients Undergoing Laparoscopic Hepatectomy
文章编号:
1006-1959（2023）22-0116-04
作者:
王 芳
（佳木斯市中心医院麻醉科，黑龙江 佳木斯 154002）
Author(s):
WANG Fang
(Department of Anesthesiology,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China)
关键词:
腹腔镜肝切除术; 右美托咪定; 脑氧饱和度; 血流动力学; 脑保护作用
Keywords:
Laparoscopic hepatectomy; Dextrmetomidine; Brain oxygen saturation; Hemodynamics; Brain protection
分类号:
R614
DOI:
10.3969/j.issn.1006-1959.2023.22.026
文献标志码:
A
摘要:
目的 研究右美托咪定对腹腔镜肝切除术（LH）老年患者脑氧饱和度及血流动力学的影响。方法 以2019年11月-2022年11月于佳木斯市中心医院行LH治疗的100例老年患者为研究对象，利用随机数字表法分为对照组（50例）与观察组（50例）。两组均采用全身麻醉，对照组于麻醉诱导前注射0.9%氯化钠，观察组则于麻醉诱导前给予右美托咪定静脉输注，比较两组围术期脑氧饱和度（rSO2）指标、不同时间点[麻醉诱导前（T0）、气腹即刻（T1）、切肝后10 min（T2）、术毕（T3）]的血流动力学水平[心率（HR）、平均动脉压（MAP）]，并统计其苏醒时间、拔管时间、术后简易精神状态检查量表（MMSE）评分及麻醉相关并发症发生率。结果 观察组围术期rSO2最小值高于对照组，rSO2下降值小于对照组（P＜0.05）；两组T1、T2时HR、MAP低于T0，但观察组T1、T2时HR、MAP高于对照组（P＜0.05）；两组苏醒时间、拔管时间比较，差异无统计学意义（P＞0.05），但观察组术后MMSE评分高于对照组（P＜0.05）；观察组麻醉相关并发症发生率为4.00%，小于对照组的16.00%（P＜0.05）。结论 右美托咪定对LH老年患者的脑氧供需平衡及血流动力学水平具有良好稳定作用，可减少麻醉对患者认知功能的影响，降低相关并发症风险。
Abstract:
Objective To study the effect of dexmedetomidine on cerebral oxygen saturation and hemodynamics in elderly patients undergoing laparoscopic hepatectomy (LH).Methods A total of 100 elderly patients who underwent LH treatment in Jiamusi Central Hospital from November 2019 to November 2022 were divided into control group (50 patients) and observation group (50 patients) by random number table method. Both groups were given general anesthesia. The control group was injected with 0.9% sodium chloride before anesthesia induction, while the observation group was given dexmedetomidine intravenous infusion before anesthesia induction. The perioperative cerebral oxygen saturation (rSO2) index, hemodynamic levels [heart rate (HR), mean arterial pressure (MAP)] at different time points [before anesthesia induction (T0), immediately after pneumoperitoneum (T1), 10 min after hepatectomy (T2), and at the end of surgery (T3)] were compared between the two groups.Meanwhile, the recovery time, extubation time, postoperative mini-mental state examination (MMSE) score and the incidence of anesthesia-related complications were counted.Results The minimum value of rSO2 in the observation group was higher than that in the control group, and the decrease of rSO2 was less than that in the control group (P<0.05). The HR and MAP at T1 and T2 in the two groups were lower than those at T0, but the HR and MAP at T1 and T2 in the observation group were higher than those in the control group (P<0.05). There was no significant difference in recovery time and extubation time between the two groups (P>0.05), but the postoperative MMSE score in the observation group was higher than that in the control group (P<0.05). The incidence of anesthesia-related complications in the observation group was 4.00%, which was lower than 16.00% in the control group (P<0.05).Conclusion Dexmedetomidine has a good stabilizing effect on cerebral oxygen supply and demand balance and hemodynamic level in elderly patients with LH, which can reduce the impact of anesthesia on cognitive function and reduce the risk of related complications.

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更新日期/Last Update: 1900-01-01