[1]陆 洋,颜永进.心肌损伤标志物cTnⅠ、CK-MB、Hcy水平与冠状动脉粥样硬化的相关性[J].医学信息,2023,36(23):59-61，65.[doi:10.3969/j.issn.1006-1959.2023.23.014]
　LU Yang,YAN Yong-jin.Correlation Between Myocardial Injury Markers cTnⅠ, CK-MB, Hcy Levels and Coronary Atherosclerosis[J].Journal of Medical Information,2023,36(23):59-61，65.[doi:10.3969/j.issn.1006-1959.2023.23.014]
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心肌损伤标志物cTnⅠ、CK-MB、Hcy水平与冠状动脉粥样硬化的相关性()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年23期
页码:
59-61，65
栏目:
论著
出版日期:
2023-12-01

文章信息/Info

Title:
Correlation Between Myocardial Injury Markers cTnⅠ, CK-MB, Hcy Levels and Coronary Atherosclerosis
文章编号:
1006-1959（2023）23-0059-04
作者:
陆 洋; 颜永进
（海安市人民医院心内科，江苏 海安 226600）
Author(s):
LU Yang; YAN Yong-jin
(Department of Cardiology,Hai’an People’s Hospital,Hai’an 226600,Jiangsu,China)
关键词:
冠状动脉粥样硬化; 肌钙蛋白Ⅰ; 肌酸激酶同工酶; 同型半胱氨酸
Keywords:
Coronary atherosclerosis; Troponin Ⅰ; Creatine kinase isoenzyme; Homocysteine
分类号:
R541.4
DOI:
10.3969/j.issn.1006-1959.2023.23.014
文献标志码:
A
摘要:
目的 研究心肌肌钙蛋白Ⅰ（cTnⅠ）、肌酸激酶同工酶（CK-MB）、同型半胱氨酸（Hcy）水平与冠状动脉粥样硬化（CAS）的相关性。方法 以2019年1月-2021年8月海安市人民医院心内科收治的120例CAS患者设为CAS组，依据其Gensini积分分为轻度狭窄组（31例）、中度狭窄组（54例）与重度狭窄组（35例），依据其冠状动脉病变支数分为单支病变组（44例）与多支病变组（76例），另取同期100例健康者为对照组，比较CAS组与对照组及CAS组中不同Gensini积分、病变支数的cTnⅠ、CK-MB、Hcy水平，并分析cTnⅠ、CK-MB、Hcy水平与CAS患者Gensini积分及病变支数的相关性。结果 CAS组cTnⅠ、CK-MB、Hcy水平高于对照组（P＜0.05）；cTnⅠ、CK-MB、Hcy水平由高到低依次为重度狭窄组＞中度狭窄组＞轻度狭窄组（P＜0.05）；多支病变组cTnⅠ、CK-MB、Hcy水平高于单只病变组（P＜0.05）；Pearson相关性分析显示，cTnⅠ、CK-MB、Hcy水平与CAS患者的Gensini积分、病变支数呈正相关（P＜0.05）。结论 cTnⅠ、CK-MB、Hcy指标与CAS病变程度密切相关。
Abstract:
Objective To study the correlation between cardiac troponin Ⅰ (cTnⅠ), creatine kinase isoenzyme (CK-MB), homocysteine (Hcy) levels and coronary atherosclerosis (CAS).Methods A total of 120 CAS patients admitted to the Department of Cardiology, Hai’an People’s Hospital from January 2019 to August 2021 were set as CAS group. According to their Gensini scores, they were divided into mild stenosis group (31 patients), moderate stenosis group (54 patients) and severe stenosis group (35 patients). According to the number of coronary artery lesions, they were divided into single-vessel disease group (44 patients) and multi-vessel disease group (76 patients). Another 100 healthy people in the same period were selected as the control group. The levels of cTnⅠ, CK-MB and Hcy in CAS group and control group and CAS group with different Gensini scores and lesion counts were compared. The correlation between the levels of cTnⅠ, CK-MB and Hcy and Gensini score and the number of lesions in CAS patients was analyzed.Results The levels of cTnⅠ, CK-MB and Hcy in the CAS group were higher than those in the control group (P<0.05). The levels of cTnⅠ, CK-MB and Hcy from high to low were severe stenosis group>moderate stenosis group>mild stenosis group (P<0.05). The levels of cTnI, CK-MB and Hcy in the multi-vessel disease group were higher than those in the multi-vessel disease group (P<0.05). Pearson correlation analysis showed that the levels of cTnⅠ, CK-MB and Hcy were positively correlated with Gensini score and number of lesions in CAS patients (P<0.05).Conclusion The levels of cTnⅠ, CK-MB and Hcy are closely related to the severity of CAS.

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更新日期/Last Update: 1900-01-01