[1]付朝霞,陈 甜.血清降钙素原在急性重症胰腺炎诊断中对患者感染程度的预测作用[J].医学信息,2023,36(23):126-128,132.[doi:10.3969/j.issn.1006-1959.2023.23.032]
　FU Zhao-xia,CHEN Tian.Predictive Effect of Serum Procalcitonin on the Degree of Infection in Patients with Severe Acute Pancreatitis[J].Journal of Medical Information,2023,36(23):126-128,132.[doi:10.3969/j.issn.1006-1959.2023.23.032]
点击复制

血清降钙素原在急性重症胰腺炎诊断中对患者感染程度的预测作用()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年23期
页码:
126-128,132
栏目:
诊疗技术
出版日期:
2023-12-01

文章信息/Info

Title:
Predictive Effect of Serum Procalcitonin on the Degree of Infection in Patients with Severe Acute Pancreatitis
文章编号:
1006-1959（2023）23-0126-04
作者:
付朝霞; 陈 甜
（高安市人民医院检验科，江西 高安 330800）
Author(s):
FU Zhao-xia; CHEN Tian
(Laboratory of Gao’an People’s Hospital,Gao’an 330800,Jiangxi,China)
关键词:
急性重症胰腺炎; 降钙素原; C反应蛋白
Keywords:
Acute severe pancreatitis; Procalcitonin; C-reactive protein
分类号:
R576.1
DOI:
10.3969/j.issn.1006-1959.2023.23.032
文献标志码:
A
摘要:
目的 研究血清降钙素原（PCT）检测对急性重症胰腺炎（ASP）及其感染程度的预测价值。方法 选取2020年1月-2023年1月高安市人民医院收治的76例ASP患者设为ASP组，另取同期体检健康者50例设为健康组，比较两组血清PCT、淀粉酶（AMY）及C反应蛋白（CRP）水平，并分析血清PCT检测对ASP的诊断价值；另统计不同疾病严重程度患者的PCT、AMY、CRP水平，分析ASP患者血清PCT水平与AMY、CRP的相关性。结果 ASP组PCT、AMY、CRP水平高于健康组（P＜0.05）。血清PCT检测对ASP疾病的诊断敏感度为89.47%，特异度为78.00%、准确性为84.92%、阳性预测值为86.08%、阴性预测值为82.98%。ASP组患者血清PCT、AMY、CRP水平由高至低依次为高危组＞中危组＞低危组（P＜0.05）。Spearman相关性分析显示，ASP患者血清PCT水平与AMY、CRP均呈正相关（r=0.418、0.537，P=0.000、0.000）。结论 血清PCT指标在ASP检测中具有较高诊断价值，其指标水平与机体感染程度密切相关。
Abstract:
Objective To study the predictive value of serum procalcitonin (PCT) in the detection of severe acute pancreatitis (ASP) and its infection degree.Methods A total of 76 patients with ASP admitted to Gao’an People’s Hospital from January 2020 to January 2023 were selected as ASP group, and 50 healthy people who underwent physical examination during the same period were selected as healthy group. The levels of serum PCT, amylase (AMY) and C-reactive protein (CRP) were compared between the two groups, and the diagnostic value of serum PCT detection for ASP was analyzed. In addition, the levels of PCT, AMY and CRP in patients with different disease severity were counted, and the correlation between serum PCT level and AMY and CRP in ASP patients was analyzed.Results The levels of PCT, AMY and CRP in the ASP group were higher than those in the healthy group (P<0.05). The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of serum PCT in the diagnosis of ASP disease were 89.47%, 78.00%, 84.92%, 86.08% and 82.98%, respectively. The levels of serum PCT, AMY and CRP in the ASP group from high to low were high-risk group>middle-risk group>low-risk group (P<0.05). Spearman correlation analysis showed that serum PCT level was positively correlated with AMY and CRP in ASP patients (r=0.418, 0.537, P=0.000, 0.000).Conclusion Serum PCT index has high diagnostic value in ASP detection, and its index level is closely related to the degree of infection.

参考文献/References:

[1]苏岚.血清HBP、PCT和HNL水平对重症急性胰腺炎患者感染及预后的预测价值[J].标记免疫分析与临床,2021,28(8):1392-1396.[2]Sepúlveda EVF,Guerrero RO.Acute pancreatitis and recurrent acute pancreatitis: an exploration of clinical and etiologic factors and outcomes - ScienceDirect[J].Jornal de Pediatria,2019,95(6):713-719.[3]高莉莎,王瑞,任宏飞,等.血清可溶性晚期糖基化终产物受体、降钙素原水平预测高脂血症性急性胰腺炎严重程度及预后的临床价值[J].实用医院临床杂志,2021,18(2):70-73.[4]赵海鹏,李俊莹,张晓红,等.肝素结合蛋白，降钙素原，中性粒细胞载脂蛋白联合检测对重症急性胰腺炎患者继发感染的评估作用[J].中国实验诊断学,2020,24(11):1816-1818.[5]Blouin AG,Meier H,Fleisher M,et al.Utility of procalcitonin as a predictor of bloodstream infections and supportive modality requirements in critically ill cancer patients[J].Clin Chim Acta,2020,510:181-185.[6]石琼梅,惠朝晖,张永顶,等.血清降钙素原联合血小板平均体积检测对急性胰腺炎的病情预测价值[J].临床输血与检验,2020,22(1):86-89.[7]Prkno A,Wacker C,Brunkhorst FM,et al.Procalcitonin-guided therapy in intensive care unit patients with severe sepsis and septic shock – a systematic review and meta-analysis[J].Critical Care,2018,17(6):291.[8]中华医学会消化病学分会胰腺疾病学组,中华胰腺病杂志编辑委员会,中华消化杂志编辑委员会.中国急性胰腺炎诊治指南(2019年,沈阳)[J].中华消化杂志,2019,39(11):721-730. [9]祁玮,黄飞,何健,等.血清C-反应蛋白、降钙素原及脂肪酶在急性胰腺炎诊断及病情评估中的应用价值[J].广西医学,2019,41(23):2984-2988.[10]陈佩,王奇军,罗建平.血清降钙素原在诊断血流感染中的临床价值研究[J].中国卫生检验杂志,2019,29(21):2616-2618.[11]王冠,郑美娜,秦少游,等.不同严重程度急性胰腺炎患者血清中PCT、hs-CRP、TNF-α水平及临床意义[J].现代生物医学进展,2019,19(14):2699-2702,2711.[12]Collins CD,Kara B,Taeyong S,et al.Analysis to determine cost-effectiveness of procalcitonin-guided antibiotic use in adult patients with suspected bacterial infection and sepsis[J].American Journal of Health-System Pharmacy,2019,76(16):1219-1225.[13]张舒,王露露,孙璟,等.降钙素原和C反应蛋白在急性胆源性胰腺炎中的诊断及预后价值比较[J].诊断学理论与实践,2019,18(6):668-671.[14]张霖,黄斌,杨斌,等.C反应蛋白、降钙素原及降钙素原乳酸比在重症急性胰腺炎继发感染的诊断价值[J].肝胆外科杂志,2018,26(6):423-426.[15]李晶箴,陈妙.血清白细胞介素-6、白细胞介素-8、降钙素原及脂肪酶联合检测在重症急性胰腺炎继发感染中的诊断价值[J].国际消化病杂志,2018,38(6):402-406.[16]Shaikh KJ,Osio VA,Leeflang MM,et al.Procalcitonin, C-reactive protein, and erythrocyte sedimentation rate for the diagnosis of acute pyelonephritis in children[J].Cochrane Database Syst Rev,2020,9(9):CD009185.[17]党晓燕,丁新爱,孙媛.重症急性胰腺炎继发感染性胰腺坏死患者细胞间黏附分子-1、降钙素原、血清C反应蛋白的表达及临床意义[J].解放军医药杂志,2018,30(8):54-57.[18]熊石龙,王治伟,迟琼,等.急性胰腺炎患者血清瘦素、血清淀粉样蛋白A及降钙素原的动态变化及临床意义[J].中华生物医学工程杂志,2019,25(4):466-470.[19]蔡栋臣,柳旦,徐卫红.降钙素原和肿瘤坏死因子对评估急性胰腺炎的病情严重程度和预后预测的临床价值[J].中国卫生检验杂志,2018,28(11):1390-1391,1394.[20]Furey C,Buxbaum J,Chambliss AB.A review of biomarker utilization in the diagnosis and management of acute pancreatitis reveals amylase ordering is favored in patients requiring laparoscopic cholecystectomy[J].Clinical Biochemistry,2019,77:54-56.[21]冯所远,符史健.血清淀粉酶、C反应蛋白、降钙素原与尿胰蛋白酶原激活肽联合检测对急性胰腺炎的诊断价值[J].中国普通外科杂志,2018,27(3):377-381.[22]高静,陈曦,杨梅,等.重症急性胰腺炎血清降钙素原含量对感染程度、肠黏膜屏障功能的评估价值[J].海南医学院学报,2018,24(4):527-529,533.[23]史苇,谭超超,吴意.MPV、PCT及IL-6联合检测在急性重症胰腺炎早期诊治中的临床意义[J].检验医学与临床,2018,15(17):2567-2570.

相似文献/References:

[1]吴君华,吴友茹,李 丹.血清降钙素原在AECOPD抗感染治疗中的应用价值研究[J].医学信息,2018,31(02):74.[doi:10.3969/j.issn.1006-1959.2018.02.025]
　WU Jun-hua,WU You-ru,LI Dan.Study on the Application Value of Serum Calcitonin in the Anti Infection Treatment of AECOPD[J].Journal of Medical Information,2018,31(23):74.[doi:10.3969/j.issn.1006-1959.2018.02.025]
[2]刘 亮.PCT和CRP联合检测对儿童呼吸道感染的临床意义[J].医学信息,2018,31(02):154.[doi:10.3969/j.issn.1006-1959.2018.02.059]
　LIU Liang.Clinical Significance of Combined Detection of PCT and CRP in Children with Respiratory Tract Infection[J].Journal of Medical Information,2018,31(23):154.[doi:10.3969/j.issn.1006-1959.2018.02.059]
[3]高艳飞.降钙素原对新生儿感染性肺炎的早期诊断价值研究[J].医学信息,2018,31(03):154.[doi:10.3969/j.issn.1006-1959.2018.03.056]
　GAO Yan-fei.Study on the Value of Procalcitonin in the Early Diagnosis of Neonatal Infectious Pneumonia[J].Journal of Medical Information,2018,31(23):154.[doi:10.3969/j.issn.1006-1959.2018.03.056]
[4]李 娟,田 鹏,刘 琦,等.血清降钙素原在儿童发热性疾病中的应用价值分析[J].医学信息,2018,31(04):102.[doi:10.3969/j.issn.1006-1959.2018.04.034]
　LI Juan,TIAN Peng,LIU Qi,et al.Analysis of the Value of Serum Procalcitonin in Children with Febrile Diseases[J].Journal of Medical Information,2018,31(23):102.[doi:10.3969/j.issn.1006-1959.2018.04.034]
[5]桑巧芳,薛赠燕,谢军培,等.血液滤过联合益生菌治疗重症急性胰腺炎患者的效果[J].医学信息,2022,35(10):149.[doi:10.3969/j.issn.1006-1959.2022.10.037]
　SANG Qiao-fang,XUE Zeng-yan,XIE Jun-pei,et al.Effect of Hemofiltration Combined with Probiotics on Patients with Severe Acute Pancreatitis[J].Journal of Medical Information,2022,35(23):149.[doi:10.3969/j.issn.1006-1959.2022.10.037]
[6]侯昌权,乔云静.内科常规治疗联合床旁连续性肾脏替代疗法治疗 急性重症胰腺炎的效果观察[J].医学信息,2018,31(13):107.[doi:10.3969/j.issn.1006-1959.2018.13.031]
　HOU Chang-quan,QIAO Yun-jing.Clinical Observation of Routine Treatment Combined with Bedside Continuous Renal Replacement therapy in the Treatment of Severe Acute Pancreatitis[J].Journal of Medical Information,2018,31(23):107.[doi:10.3969/j.issn.1006-1959.2018.13.031]
[7]付云杰.超敏C反应蛋白、前清蛋白及降钙素原在重症肺炎患者中的变化及诊断的临床意义[J].医学信息,2018,31(24):84.[doi:10.3969/j.issn.1006-1959.2018.24.022]
　FU Yun-jie.Changes of Hypersensitive C-reactive Protein,Proalbumin and Procalcitonin in Patients with Severe Pneumonia and Its Clinical Significance[J].Journal of Medical Information,2018,31(23):84.[doi:10.3969/j.issn.1006-1959.2018.24.022]
[8]刘伟娜.CD64感染指数、BODE指数与降钙素原在慢阻肺患者中的水平变化[J].医学信息,2019,32(06):125.[doi:10.3969/j.issn.1006-1959.2019.06.039]
　LIU Wei-na.Changes of CD64 Infection Index,BODE Index and Procalcitonin Levels in Patients with Chronic Obstructive Pulmonary Disease[J].Journal of Medical Information,2019,32(23):125.[doi:10.3969/j.issn.1006-1959.2019.06.039]
[9]田 刚,丁俊杰,宋 敏,等.两种不同检测系统测定血清降钙素原的比较实验研究[J].医学信息,2019,32(06):169.[doi:10.3969/j.issn.1006-1959.2019.06.055]
　TIAN Gang,DING Jun-jie,SONG Min,et al.Comparative Experimental Study on Serum Procalcitonin by Two Different Detection Systems[J].Journal of Medical Information,2019,32(23):169.[doi:10.3969/j.issn.1006-1959.2019.06.055]
[10]张文旭,徐 绸.红细胞宽度对脓毒症患者病情诊断及预后评估的价值[J].医学信息,2022,35(14):71.[doi:10.3969/j.issn.1006-1959.2022.14.015]
　ZHANG Wen-xu,XU Chou.The Value of Red-blood-cell Distribution Width in the Diagnosis and Prognosis of Patients with Sepsis[J].Journal of Medical Information,2022,35(23):71.[doi:10.3969/j.issn.1006-1959.2022.14.015]

更新日期/Last Update: 1900-01-01