[1]孙燕飞.替诺福韦酯治疗乙型肝炎的效果及对复发率的影响[J].医学信息,2024,37(08):121-124.[doi:10.3969/j.issn.1006-1959.2024.08.024]
　SUN Yan-fei.Effect of Tenofovir Disoproxil in the Treatment of Hepatitis B and its Effect on Recurrence Rate[J].Journal of Medical Information,2024,37(08):121-124.[doi:10.3969/j.issn.1006-1959.2024.08.024]
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替诺福韦酯治疗乙型肝炎的效果及对复发率的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年08期
页码:
121-124
栏目:
论著
出版日期:
2024-04-15

文章信息/Info

Title:
Effect of Tenofovir Disoproxil in the Treatment of Hepatitis B and its Effect on Recurrence Rate
文章编号:
1006-1959（2024）08-0121-04
作者:
孙燕飞
（安远县人民医院感染科，江西 安远 342199）
Author(s):
SUN Yan-fei
(Department of Infection,Anyuan County People’s Hospital,Anyuan 342199,Jiangxi,China)
关键词:
福韦酯; 乙型肝炎; HBV-DNA转阴率; HBeAg转阴率; 复发率
Keywords:
Tenofovir disoproxil; Hepatitis B; HBV-DNA negative rate; HBeAg negative rate; Recurrence rate
分类号:
R512.6+2
DOI:
10.3969/j.issn.1006-1959.2024.08.024
文献标志码:
A
摘要:
目的 观察替诺福韦酯治疗乙型肝炎的临床效果及对复发率的影响。方法 选取2021年12月-2022年12月我院诊治的72例乙型肝炎患者为研究对象，采用随机数字表法分为对照组和观察组，各组36例。对照组采用恩替卡韦治疗，观察组采用替诺福韦酯治疗，比较两组临床效果、HBV-DNA转阴率、HBeAg转阴率、肝功能指标[丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转氨酶（AST）、总胆红素（TbiL）]、不良反应发生率、复发率。结果 观察组治疗总有效率为94.44%，高于对照组的80.56%（P＜0.05）；观察组HBV-DNA转阴率、HBeAg转阴率均高于对照组（P＜0.05）；两组治疗后ALT、AST、TbiL均低于治疗前，且观察组低于对照组（P＜0.05）；观察组不良反应发生率为8.33%，低于对照组的19.44%（P＜0.05）；随访3个月，观察组复发率为11.11%，低于对照组的25.00%（P＜0.05）。结论 替诺福韦酯可提升乙型肝炎患者治疗效果，改善其肝功能，促进HBV-DNA和HBeAg转阴，降低不良反应发生率和复发率，具有较理想的远期临床疗效。
Abstract:
Objective To observe the clinical effect of tenofovir disoproxil in the treatment of hepatitis B and its effect on recurrence rate.Methods A total of 72 patients with hepatitis B diagnosed and treated in our hospital from December 2021 to December 2022 were selected as the research objects. They were divided into control group and observation group by random number table method, with 36 patients in each group. The control group was treated with entecavir, and the observation group was treated with tenofovir disoproxil. The clinical effect, HBV-DNA negative conversion rate, HBeAg negative conversion rate, liver function index [alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TbiL)], incidence of adverse reactions and recurrence rate were compared between the two groups.Results The total effective rate of treatment in the observation group was 94.44%, which was higher than 80.56% in the control group (P<0.05). The negative conversion rates of HBV-DNA and HBeAg in the observation group were higher than those in the control group (P<0.05). After treatment, ALT, AST and TbiL in the two groups were lower than those before treatment, and those in the observation group were lower than those in the control group (P<0.05). The incidence of adverse reactions in the observation group was 8.33%, which was lower than 19.44% in the control group (P<0.05). After 3 months of follow-up, the recurrence rate of the observation group was 11.11%, which was lower than 25.00% of the control group (P<0.05).Conclusion Tenofovir disoproxil can improve the therapeutic effect of patients with hepatitis B, improve their liver function, promote the negative conversion of HBV-DNA and HBeAg, reduce the incidence of adverse reactions and recurrence rate, and has ideal long-term clinical efficacy.

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更新日期/Last Update: 1900-01-01