[1]蒋凯丽,钟 平.血尿酸、血脂水平与帕金森病临床关系研究[J].医学信息,2024,37(13):80-84.[doi:10.3969/j.issn.1006-1959.2024.13.015]
　Study on the Clinical Relationship Between Serum Uric Acid,Blood Lipid Levels and Parkinsons Disease.Study on the Clinical Relationship Between Serum Uric Acid, Blood Lipid Levels and Parkinson’s Disease[J].Journal of Medical Information,2024,37(13):80-84.[doi:10.3969/j.issn.1006-1959.2024.13.015]
点击复制

血尿酸、血脂水平与帕金森病临床关系研究()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年13期
页码:
80-84
栏目:
论著
出版日期:
2024-07-01

文章信息/Info

Title:
Study on the Clinical Relationship Between Serum Uric Acid, Blood Lipid Levels and Parkinson’s Disease
文章编号:
1006-1959（2024）13-0080-05
作者:
蒋凯丽; 钟 平
（安徽医科大学附属宿州医院神经内科，安徽 宿州 234000）
Author(s):
Study on the Clinical Relationship Between Serum Uric Acid;  Blood Lipid Levels and Parkinson’s Disease
(Department of Neurology,Suzhou Hospital of Anhui Medical University,Suzhou 234000,Anhui,China)
关键词:
帕金森病; 血尿酸; 血脂
Keywords:
Parkinson’s disease; Blood uric acid; Blood lipid
分类号:
R742.5
DOI:
10.3969/j.issn.1006-1959.2024.13.015
文献标志码:
A
摘要:
目的 探讨血尿酸（BUA）、血脂水平与帕金森病（PD）的相关性。方法 选取2021年7月-2023年7月安徽医科大学附属宿州医院神经内科住院及门诊≥45岁的PD患者96例作为PD组，另选取100例相同年龄组的健康体检人员作为对照组，比较PD组与对照组外周血TC、TG、HDL-C、LDL-C、BUA、ApoA、ApoB水平，并采用二元多因素Logistic回归分析BUA及血脂水平与PD患病风险的关系。结果 PD组TG、HDL-C、BUA、ApoA水平均低于对照组（P＜0.05）。二元多因素Logistic回归分析显示，BUA、TG、HDL-C、ApoA是PD的保护性因素，年龄为危险因素（P＜0.05）。ROC曲线分析显示，BUA曲线下面积为0.611，灵敏度为54.20%，特异度为63.00%；TG曲线下面积为0.685，灵敏度为84.40%，特异度为44.00%；HDL-C曲线下面积为0.632，灵敏度为46.90%，特异度为75.00%；ApoA曲线下面积为0.646，灵敏度为41.70%，特异度为83.00%；年龄曲线下面积为0.672，灵敏度为80.20%，特异度为54.00%。结论 PD患者BUA及血脂较正常对照组减低，且BUA、TG、HDL-C、ApoA、年龄与PD发病密切相关。
Abstract:
Objective To investigate the correlation between blood uric acid (BUA), blood lipid levels and Parkinson’s disease (PD).Methods From July 2021 to July 2023, 96 PD patients aged≥45 years in the Department of Neurology, Suzhou Hospital of Anhui Medical University were selected as PD group, and 100 healthy people in the same age group were selected as control group. The levels of TC, TG, HDL-C, LDL-C, BUA, ApoA and ApoB in peripheral blood of PD group and control group were compared, and the relationship between BUA and blood lipid levels and the risk of PD was analyzed by binary multivariate Logistic regression.Results The levels of TG, HDL-C, BUA, ApoA in the PD group were lower than those in the control group (P<0.05). Binary multivariate Logistic regression analysis showed that BUA, TG, HDL-C and ApoA were protective factors for PD, and age was a risk factor (P<0.05). ROC curve analysis showed that the area under the BUA curve was 0.611, the sensitivity was 54.20%, and the specificity was 63.00%; the area under the TG curve was 0.685, the sensitivity was 84.40%, and the specificity was 44.00%; the area under the curve of HDL-C was 0.632, the sensitivity was 46.90%, and the specificity was 75.00%; the area under the curve of ApoA was 0.646, the sensitivity was 41.70%, and the specificity was 83.00%; the area under the age curve was 0.672, the sensitivity was 80.20%, and the specificity was 54.00%.Conclusion BUA and blood lipid in PD patients are lower than those in normal control group, while BUA, TG, HDL-C, ApoA and age are closely related to the pathogenesis of PD.

参考文献/References:

[1]Simon DK,Tanner CM,Brundin P.Parkinson Disease Epidemiology,Pathology,Genetics,and Pathophysiology[J].Clin Geriatr Med,2020,36(1):1-12.[2]Ye H,Robak LA,Yu M,et al.Genetics and Pathogenesis of Parkinson’s Syndrome[J].Annu Rev Pathol,2023,18:95-121.[3]Cabreira V,Massano J.Parkinson’s Disease: Clinical Review and Update[J].Acta Med Port,2019,32(10):661-670.[4]Leite Silva ABR,Gon?觭alves de Oliveira RW,Diógenes GP,et al.Premotor,nonmotor and motor symptoms of Parkinson’s Disease: A new clinical state of the art[J].Ageing Res Rev,2023,84:101834.[5]Ruoqing J.Parkinson’s disease: Pathology and treatment[J].AIP Conf Proc,2022,2589(1):020003.[6]Rajan S,Kaas B.Parkinson’s Disease: Risk Factor Modification and Prevention[J].Semin Neurol,2022.42(5):626-638.[7]Bloem BR,Okun MS,Klein C.Parkinson’s disease[J].The Lancet,2021,397(10291):2284-2303.[8]Chang KH,Chen CM.The Role of Oxidative Stress in Parkinson’s Disease[J].Antioxidants,2020,9(7):597-627.[9]Shi X,Zheng J,Ma J,et al.Low serum uric acid levels are associated with the nonmotor symptoms and brain gray matter volume in Parkinson’s disease[J].Neurological Sciences,2021,43(3):1747-1754.[10]Fais M,Dore A,Galioto M,et al.Parkinson’s Disease-Related Genes and Lipid Alteration[J].Int J Mol Sci,2021,22(14):7630-7642.[11]Dionísio PA,Amaral JD,Rodrigues CMP.Oxidative stress and regulated cell death in Parkinson’s disease[J].Ageing Res Rev,2021,67:101263.[12]Ganguly U,Singh S,Pal S,et al.Alpha-Synuclein as a Biomarker of Parkinson’s Disease: Good,but Not Good Enough[J].Front Aging Neurosci,2021,13:702639.[13]D?觍n?觍u A,Dumitrescu L,Lefter A,et al.Serum Uric Acid Levels in Parkinson’s Disease: A Cross-Sectional Electronic Medical Record Database Study from a Tertiary Referral Centre in Romania[J].Medicina (Kaunas),2022,58(2):245-255.[14]Seifar F,Dinasarapu AR,Jinnah HA.Uric Acid in Parkinson’s Disease: What Is the Connection?[J] Mov Disord,2022,37(11):2173-2183.[15]Lawton M,Baig F,Toulson G,et al.Blood biomarkers with Parkinson’s disease clusters and prognosis: The oxford discovery cohort[J].Mov Disord,2020,35(2):279-287.[16]Graｚyńska A,Adamczewska K,Antoniuk S,et al.The Influence of Serum Uric Acid Level on Non-Motor Symptoms Occurrence and Severity in Patients with Idiopathic Parkinson’s Disease and Atypical Parkinsonisms-A Systematic Review[J].Medicina (Kaunas),2021,57(9):972-984.[17]Frei B,England L,Ames BN.Ascorbate is an outstanding antioxidant in human blood plasma[J].Proc Natl Acad Sci U S A,1989,86(16):6377-6781.[18]Koros C,Simitsi AM,Papagiannakis N,et al.Serum Uric Acid as a Putative Biomarker in Prodromal Parkinson’s Disease: Longitudinal Data from the PPMI Study[J].J Parkinsons Dis,2023,13(5):811-818.[19]Fanning S,Selkoe D,Dettmer U.Parkinson’s disease: proteinopathy or lipidopathy?[J].NPJ Parkinsons Dis,2020,6:3-11.[20]Galper J,Dean NJ,Pickford R,et al.Lipid pathway dysfunction is prevalent in patients with Parkinson’s disease[J].Brain,2022,145(10):3472-3487.[21]Pingale TD,Gupta GL.Novel therapeutic approaches for Parkinson’s disease by targeting brain cholesterol homeostasis[J].J Pharm Pharmacol,2021,73(7):862-873.[22]García-Sanz P,M F G Aerts J,Moratalla R.The Role of Cholesterol in α-Synuclein and Lewy Body Pathology in GBA1 Parkinson’s Disease[J].Mov Disord,2021,36(5):1070-1085.[23]Turri M,Marchi C,Adorni MP,et al.Emerging role of HDL in brain cholesterol metabolism and neurodegenerative disorders[J].Biochim Biophys Acta Mol Cell Biol Lipids,2022,1867(5):159123.[24]Cho KH.The Current Status of Research on High-Density Lipoproteins (HDL): A Paradigm Shift from HDL Quantity to HDL Quality and HDL Functionality[J].Int J Mol Sci,2022,23(7):3967-3986.[25]Hu G.Total cholesterol and the risk of Parkinson’s disease: a review for some new findings[J].Parkinsons Dis,2010,2010:836962.[26]Jiang Z,Xu X,Gu X,et al.Effects of Higher Serum Lipid Levels on the Risk of Parkinson’s Disease: A Systematic Review and Meta-Analysis[J].Front Neurol,2020,11:597-607.

相似文献/References:

[1]王姝,莫英绪,王大成.帕金森病发病因素的研究现状[J].医学信息,2018,31(01):46.[doi:10.3969/j.issn.1006-1959.2018.01.017]
　WANG Shu,MO Ying-xu,WANG Da-cheng.Research Status of the Factors of Parkinson's Disease[J].Journal of Medical Information,2018,31(13):46.[doi:10.3969/j.issn.1006-1959.2018.01.017]
[2]刘 璐,秦新月.阿尔茨海默病患者血尿酸水平变化的研究[J].医学信息,2018,31(02):96.[doi:10.3969/j.issn.1006-1959.2018.02.033]
　LIU Lu,QIN Xin-yue.Study on the Changes of Serum Uric Acid in Alzheimer 's Disease Patients[J].Journal of Medical Information,2018,31(13):96.[doi:10.3969/j.issn.1006-1959.2018.02.033]
[3]刘 阳,王惠凌,安 迪,等.进行性核上性麻痹1例报告[J].医学信息,2018,31(05):192.[doi:10.3969/j.issn.1006-1959.2018.05.073]
[4]王明远,陈海燕,张延朋,等.颈动脉斑块、血同型半胱氨酸及血尿酸对短暂性脑缺血 发作进程的影响研究[J].医学信息,2018,31(08):65.[doi:10.3969/j.issn.1006-1959.2018.08.020]
　WANG Ming-yuan,CHEN Hai-yan,ZHANG Yan-peng,et al.Effects of Carotid Plaque,Homocysteine and Serum Uric Acid on Transient Ischemic Attack[J].Journal of Medical Information,2018,31(13):65.[doi:10.3969/j.issn.1006-1959.2018.08.020]
[5]张 铭,徐 蔷,肖 帆,等.芹菜籽提取物对高尿酸血症模型大鼠的血尿酸以及 抗氧化能力的影响[J].医学信息,2018,31(13):84.[doi:10.3969/j.issn.1006-1959.2018.13.024]
　ZHANG Ming,XU Qiang,XIAO Fan,et al.Effects of Celery Seed Extract on Serum Uric Acid and Antioxidant Capacity of Hyperuricemia Rats[J].Journal of Medical Information,2018,31(13):84.[doi:10.3969/j.issn.1006-1959.2018.13.024]
[6]樊 毅.帕金森病嗅觉改变的相关性研究[J].医学信息,2018,31(17):95.[doi:10.3969/j.issn.1006-1959.2018.17.029]
　FAN Yi.Correlation Study of Olfactory Changes in Parkinson's Disease[J].Journal of Medical Information,2018,31(13):95.[doi:10.3969/j.issn.1006-1959.2018.17.029]
[7]承良凤.芜湖地区痛风急性发作诱因及临床生化特征初探[J].医学信息,2019,32(10):85.[doi:10.3969/j.issn.1006-1959.2019.10.028]
　CHENG Liang-feng.Preliminary Study on the Causes and Clinical Biochemical Characteristics of Acute Gout in Wuhu Area[J].Journal of Medical Information,2019,32(13):85.[doi:10.3969/j.issn.1006-1959.2019.10.028]
[8]孙 洋,高 山,宋 京,等.血尿酸、同型半胱氨酸、脑钠肽、肌钙蛋白Ⅰ与急性冠脉综合征病变程度的相关性[J].医学信息,2020,33(02):105.[doi:10.3969/j.issn.1006-1959.2020.02.028]
　SUN Yang,GAO Shan,SONG Jing,et al.Correlation Between Serum Uric Acid,Homocysteine,Brain Natriuretic Peptide,TroponinⅠ and the Severity of Acute Coronary Syndrome[J].Journal of Medical Information,2020,33(13):105.[doi:10.3969/j.issn.1006-1959.2020.02.028]
[9]陈凤全.帕金森病的诊治现状及进展[J].医学信息,2020,33(12):43.[doi:10.3969/j.issn.1006-1959.2020.12.014]
　CHEN Feng-quan.Status and Progress of Diagnosis and Treatment of Parkinson’s Disease[J].Journal of Medical Information,2020,33(13):43.[doi:10.3969/j.issn.1006-1959.2020.12.014]
[10]彭雪琴,马厚勋.血尿酸与骨密度的相关性[J].医学信息,2020,33(16):31.[doi:10.3969/j.issn.1006-1959.2020.16.010]
　PENG Xue-qin,MA Hou-xun.Correlation Between Blood Uric Acid and Bone Density[J].Journal of Medical Information,2020,33(13):31.[doi:10.3969/j.issn.1006-1959.2020.16.010]

更新日期/Last Update: 1900-01-01