[1]臧莎莎,赵 晴,肖 暖.糖尿病肾病病理机制及其与葡萄糖目标范围内时间的关系研究[J].医学信息,2024,37(13):185-188.[doi:10.3969/j.issn.1006-1959.2024.13.040]
 Study on the Pathological Mechanism of Diabetic Nephropathy and its Relationship with the Time in Target Glucose Range.Study on the Pathological Mechanism of Diabetic Nephropathy and its Relationship with the Time in Target Glucose Range[J].Journal of Medical Information,2024,37(13):185-188.[doi:10.3969/j.issn.1006-1959.2024.13.040]
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糖尿病肾病病理机制及其与葡萄糖目标范围内时间的关系研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年13期
页码:
185-188
栏目:
综述
出版日期:
2024-07-01

文章信息/Info

Title:
Study on the Pathological Mechanism of Diabetic Nephropathy and its Relationship with the Time in Target Glucose Range
文章编号:
1006-1959(2024)13-0185-04
作者:
臧莎莎赵 晴肖 暖
(河北大学附属医院老年医学科,河北 保定 071000)
Author(s):
Study on the Pathological Mechanism of Diabetic Nephropathy and its Relationship with the Time in Target Glucose Range
(Department of Geratology,the Affiliated Hospital of Hebei University School of Medicine,Baoding 071000,Hebei,China)
关键词:
葡萄糖目标范围内时间糖尿病并发症糖尿病肾病
Keywords:
Time in rangeDiabetes complicationsDiabetic nephropathy
分类号:
R692
DOI:
10.3969/j.issn.1006-1959.2024.13.040
文献标志码:
A
摘要:
随着糖尿病发病率的增高,糖尿病肾病(DKD)的发病率亦逐年递增。由糖尿病导致的终末期肾脏病发病率已经超过了肾小球肾炎引起的终末期肾脏病,是目前造成终末期肾病的首要原因。因此,对DKD患者进行长期综合管理与治疗尤为重要,而血糖监测是其管理的重要组成部分。《中国2型糖尿病防治指南(2020年版)》推荐葡萄糖目标范围内时间(TIR)这一指标作为糖尿病患者血糖监测管理的重要手段。对于DKD患者的血糖管理而言,TIR亦发挥重要角色。本文从TIR产生背景、DKD的诊断及病理机制、TIR与DKD关系研究方面作一综述。
Abstract:
With the increasing incidence of diabetes, the incidence of diabetic kidney disease (DKD) is also increasing year by year. The incidence of end-stage renal disease caused by diabetes has exceeded that caused by glomerulonephritis, which is the primary cause of end-stage renal disease. Therefore, long-term comprehensive management and treatment of patients with diabetic nephropathy is particularly important, and blood glucose monitoring is an important part of its management. The Clinical Guidelines for Prevention and Treatment of Type 2 Diabetes Mellitus in the Elderly in China (2020 edition) recommends the indicator of time in range (TIR) as an important means of blood glucose monitoring and management in diabetes mellitus patients. TIR also plays an important role in the management of blood glucose in patients with diabetic nephropathy. This article reviews the background of TIR, the diagnosis and pathological mechanism of diabetic nephropathy, and the relationship between TIR and diabetic nephropathy.

参考文献/References:

[1]姚路红,张军.SGLT2抑制剂在老年糖尿病人群中应用的相关研究[J].中国循证心血管医学杂志,2012,13(7):895-896.[2]李洪梅,朱海清.中国糖尿病肾脏病防治指南(2021年版)解读[J].中国医刊,2022,57(2):133-138.[3]Bonner R,Albajrami O,Hudspeth J,et al.Diabetic Kidney Disease[J].Prim Care,2020,47(4):645-659.[4]Prandi FR,Barone L,Lecis D,et al.Biomolecular Mechanisms of Cardiorenal Protection with Sodium-Glucose Co-Transporter 2 Inhibitors[J].Biomolecules,2022,12(10):1349.[5]Erraez S,López-Mesa M,Gómez-Fernández P.Mineralcorticoid receptor blockers in chronic kidney disease[J].Nefrologia (Engl Ed).2021,41(3):258-275.[6]曹晔,杨丹,苏津,等.糖尿病肾病患者肾素-血管紧张素-醛固酮系统与血流动力学的关系[J].临床检验杂志,2012,12(22):1004-1005.[7]]Lin YC,Chang YH,Yang SY,et al.Update of pathophysiology and management of diabetic kidney disease[J].J Formos Med Assoc,2018,117(8):662-675.[8]Greco EV,Russo G,Giandalia A,et al.GLP-1 Receptor Agonists and Kidney Protection[J].Medicina (Kaunas),2019,55(6):233.[9]Tan C,Gu J,Li T,et al.Inhibition of aerobic glycolysis alleviates sepsis induced acute kidney injury by promoting lactate/Sirtuin 3/AMPK regulated autophagy[J].Int J Mol Med,2021,47(3):19.[10]Jigheh ZA,Haghjo AG,Argani H,et al.Empagliflozin alleviates renal inflammation and oxidative stress in streptozotocin-induced diabetic rats partly by repressing HMGB1-TLR4 receptor axis[J].Iran J Basic Med Sci,2019,22(4):384-390.[11]Pichler R,Afkarian M,Dieter BP,et al.Immunity and inflammation in diabetic kidney disease: translating mechanisms to biomarkers and treatment targets[J].Am J Physiol Renal Physiol,2017,312(4):F716-F731.[12]Li X,Lu L,Hou W,et al.Epigenetics in the pathogenesis of diabetic nephropathy[J].Acta Biochim Biophys Sin (Shanghai),2022,54(2):163-172.[13]Lu Q,Zhou Y,Hao M,et al.The mTOR promotes oxidative stress- induced apoptosis of mesangial cells in diabetic nephropathy[J].Mol Cell Endocrinol,2018,473:31-43.[14]Barati MT,Merchant ML,Kain AB,et al.Proteomic analysis defines altered cellular redox pathways and advanced glycation end-product metabolism in glomeruli of db/db diabetic mice[J].Am J Physiol Renal Physiol,2007,293:F1157–F1165.[15]吕玲.葡萄糖目标范围内时间与2型糖尿病肾脏疾病的相关性研究[D].长春:吉林大学,2022.[16]Tuttle KR,Agarwal R,Alpers CE,et al.Molecular mechanisms and therapeutic targets for diabetic kidney disease[J].Kidney Int,2022,102(2):248-260.[17]Koch EAT,Nakhoul R,Nakhoul F,et al.Autophagy in diabetic nephropathy: a review[J].Int Urol Nephrol,2020,52(9):1705-1712.[18]Bermejo S,García CO,Rodríguez E,et al.The renin-angiotensin-aldosterone system blockade in patients with advanced diabetic kidney disease[J].Nefrologia (Engl Ed),2018,38(2):197-206.[19]莫一菲,包玉倩.《中国血糖监测临床应用指南(2021年版)》解读[J].中华糖尿病杂志,2021,13(10):926-929.[20]Advani A.Positioning time in range in diabetes management[J].Diabetologia,2020,63(2):242-252.[21]Beck RW,Bergenstal RM,Cheng P,et al.The Relationships Between Time in Range,Hyperglycemia Metrics,and HbA1c[J].J Diabetes Sci Technol,2019,13(4):614-626.[22]Kalra S,Shaikh S,Priya G,et al.Correction to: Individualizing Time-in-Range Goals in Management of Diabetes Mellitus and Role of Insulin: Clinical Insights From a Multinational Panel[J].Diabetes Ther,2021,12(9):2627-2629.[23]Runge AS,Kennedy L,Brown AS,et al.Does Time-in-Range Matter Perspectives From People With Diabetes on the Success of Current Therapies and the Drivers of Improved Outcomes[J].Clin Diabetes,2018,36(2):112-119.[24]Vigersky RA,McMahon C.The Relationship of Hemoglobin A1C to Time-in-Range in Patients with Diabetes[J].Diabetes Technol Ther,2019,21(2):81-85.[25]陆菊明.葡萄糖目标范围内时间:从指南角度看血糖达标[J].药品评价,2021,18(9):513-515.[26]Barrera-Chimal J,Jaisser F.Pathophysiologic mechanisms in diabetic kidney disease: A focus on current and future therapeutic targets[J].Diabetes Obes Metab,2020,22 Suppl 1:16-31. [27]Beck RW,Bergenstal RM,Riddlesworth TD,et al.Validation of time in range as an outcome measure for diabetes clinical trials[J].Diabetes Care,2019,42(3):400-405.[28]Yoo JH,Choi MS,Ahn J,et al.Association Between Continuous Glucose Monitoring-Derived Time in Range, Other Core Metrics, and Albuminuria in Type 2 Diabetes[J].Diabetes Technol Ther,2020,22(10):768-776.[29]Lu J,Ma X,Zhou J,et al.Association of Time in Range,as Assessed by Continuous Glucose Monitoring,With Diabetic Retinopathy in Type 2 Diabetes[J].Diabetes Care,2018,41(11):2370-2376.[30]Sheng X,Xiong GH,Yu PF,et al.The Correlation between Time in Range and Diabetic Microvascular Complications Utilizing Information Management Platform[J].Int J Endocrinol,2020,2020:8879085.

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更新日期/Last Update: 1900-01-01