[1]韩丽丽.盐酸羟考酮注射液用于全麻患者术后镇痛的 有效性和安全性研究[J].医学信息,2019,32(13):145-146.[doi:10.3969/j.issn.1006-1959.2019.13.045]
　HAN Li-li.Efficacy and Safety of Oxycodone Hydrochloride Injection for Postoperative Analgesia in Patients with General Anesthesia[J].Journal of Medical Information,2019,32(13):145-146.[doi:10.3969/j.issn.1006-1959.2019.13.045]
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盐酸羟考酮注射液用于全麻患者术后镇痛的 有效性和安全性研究()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年13期
页码:
145-146
栏目:
药物与临床
出版日期:
2019-07-01

文章信息/Info

Title:
Efficacy and Safety of Oxycodone Hydrochloride Injection for Postoperative Analgesia in Patients with General Anesthesia
文章编号:
1006-1959（2019）13-0145-02
作者:
韩丽丽
首都医科大学石景山教学医院药剂科，北京 100043
Author(s):
HAN Li-li
Department of Pharmacy,Shijingshan Teaching Hospital,Capital Medical University,Beijing 100043, China
关键词:
盐酸羟考酮; 全麻术; 镇痛效果; 安全性
Keywords:
Key words：Oxycodone hydrochloride; General anesthesia; Analgesic effect; Safety
分类号:
R614.2
DOI:
10.3969/j.issn.1006-1959.2019.13.045
文献标志码:
A
摘要:
目的 研究盐酸羟考酮注射液用于全麻患者术后镇痛的有效性和安全性。方法 选取2017年1月~2018年1月在我院行全麻手术的82例患者作为研究对象，随机分为对照组和观察组，各41例。对照组术后采用硫酸吗啡注射液镇痛，观察组术后采用盐酸羟考酮注射液镇痛，对比两组患者术后不同时间疼痛度（VAS）评分、不良反应发生率以及满意度。结果 观察组术后5、8、12、24 h各时间点VAS评分低于对照组，差异有统计学意义（P＜0.05）；观察组不良反应发生率为4.88%，低于对照组的17.07%，差异有统计学意义（P＜0.05）；观察组患者满意度为97.56%，高于对照组的87.80%，差异有统计学意义（P＜0.05）。结论 盐酸羟考酮注射液用于全麻患者术后镇痛效果良好，不良反应少，安全性高，具有较高的满意度。
Abstract:
Abstract：Objective To study the efficacy and safety of oxycodone hydrochloride injection for postoperative analgesia in patients with general anesthesia. Methods 82 patients who underwent general anesthesia in our hospital from January 2017 to January 2018 were enrolled in the study. They were randomly divided into the control group and the observation group, with 41 cases in each group. The control group was treated with morphine sulfate injection for analgesia. The observation group was treated with oxycodone hydrochloride injection for analgesia. The pain score (VAS) score, adverse reaction rate and patient satisfaction were compared between the two groups. Results The VAS scores of the observation group at 5, 8,12 and 24 h after operation were lower than those of the control group,the difference was statistically significant (P<0.05). The incidence of adverse reactions in the observation group was 4.88%, which was lower than 17.07% in the control group,the difference was statistically significant (P<0.05). The satisfaction of the observation group was 97.56%. In the control group, 87.80%, the difference was statistically significant (P<0.05). Conclusion Oxycodone hydrochloride injection is effective for postoperative analgesia in patients with general anesthesia, with less adverse reactions, high safety and high satisfaction.

参考文献/References:

[1]徐建国.盐酸羟考酮的药理学和临床应用[J].临床麻醉学杂志,2014,30(5):511-513. [2]缪小勇,徐葭,曹建平.盐酸羟考酮注射液在腔镜手术后镇痛的临床应用[J].临床军医杂志,2015,43(8):781-783. [3]连祥基,余革,张亮,等.盐酸羟考酮用于老年患者术后镇痛的疗效观察[J].临床合理用药杂志,2015,8(4):32-33. [4]许幸,吴新民,薛张纲.盐酸羟考酮注射液用于全麻患者术后镇痛的有效性和安全性:前瞻性、随机、盲法、多中心、阳性对照临床研究[J].中华麻醉学杂志,2014,33(3):269-273. [5]周薇,李瑞,王梦鸽,等.盐酸羟考酮与地佐辛超前镇痛用于妇科腹腔镜手术的比较[J].实用医学杂志,2015,31(5):828-829.

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更新日期/Last Update: 2019-07-01