[1]王 鹏,郝敬春,厉志洪,等.超微血管成像技术评估类风湿关节炎手指关节 亚临床炎及分布特点[J].医学信息,2019,32(14):98-100.[doi:10.3969/j.issn.1006-1959.2019.14.030]
　WANG Peng,HAO Jing-chun,LI Zhi-hong,et al.Evaluation of Subclinical Inflammation and Distribution of Finger Joints in Rheumatoid Arthritis by Ultra-Microvascular Imaging[J].Journal of Medical Information,2019,32(14):98-100.[doi:10.3969/j.issn.1006-1959.2019.14.030]
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超微血管成像技术评估类风湿关节炎手指关节 亚临床炎及分布特点()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年14期
页码:
98-100
栏目:
临床研究
出版日期:
2019-07-15

文章信息/Info

Title:
Evaluation of Subclinical Inflammation and Distribution of Finger Joints in Rheumatoid Arthritis by Ultra-Microvascular Imaging
文章编号:
1006-1959（2019）14-0098-03
作者:
王 鹏; 郝敬春; 厉志洪; 魏梅梅; 王东玮; 韩 森; 刘 茹
徐州市中心医院超声科，江苏 徐州 221009
Author(s):
WANG Peng; HAO Jing-chun; LI Zhi-hong; WEI Mei-mei; WANG Dong-wei; HAN Sen; LIU Ru
Department of Ultrasound,Xuzhou Central Hospital,Xuzhou 221009,Jiangsu,China
关键词:
超微血流成像; 类风湿关节炎; 指间关节; 掌指关节
Keywords:
Key words：Ultrastructural blood flow imaging; Rheumatoid arthritis; Interphalangeal joint;  Metacarpophalangeal joint
分类号:
R593.22；R445.1
DOI:
10.3969/j.issn.1006-1959.2019.14.030
文献标志码:
A
摘要:
目的 采用超微血流成像（SMI）技术评估类风湿性关节炎（RA）患者掌指关节（MCP）及近端指间关节（PIP）亚临床活动性炎的分布特点。方法 对2015年11月~2018年9月在我院接受治疗的临床缓解的23例RA患者MCP及PIP各230个关节进行超声检查，利用灰阶超声观察滑膜增厚程度，并利用SMI技术观察血流分布，比较不同关节及同一关节掌侧及背侧关节面受累程度差异。结果 临床缓解的23例患者超声完全缓解率仅21.74%；230个受检关节中SMI对MCP和PIP滑膜区血流信号的显示率分别为17.83%、16.96%，差异无统计学意义（P＞0.05）；MCP主要以背侧滑膜血流信号显示为主，显示率63.41%较PIP背侧显示率33.33%高，PIP主要以掌侧滑膜血流信号显示为主，显示率53.85%较MCP掌侧显示率21.95%高，差异均具有统计学意义（P＜0.05）；MCP和PIP受累程度比较，差异无统计学意义（P＞0.05）。结论 SMI技术能够客观地评估RA患者MCP及PIP亚临床活动性炎，其中MCP亚临床活动性炎主要分布于背侧滑膜，PIP则主要分布于掌侧滑膜。
Abstract:
Abstract：Objective To evaluate the distribution of subclinical active inflammation of the metacarpophalangeal joint (MCP) and proximal interphalangeal joint (PIP) in patients with rheumatoid arthritis (RA) using ultrasonographic imaging (SMI).Methods From November 2015 to September 2018, 23 patients with RA who underwent clinical remission in our hospital underwent ultrasonography of MCP and PIP 230 joints. Gray scale ultrasound was used to observe the degree of synovial thickening and SMI technique was used. Observe the blood flow distribution and compare the differences in the degree of involvement of different joints and the volar and dorsal articular surfaces of the same joint.Results The complete response rate of ultrasound in 23 patients with clinical remission was only 21.74%; the display rate of SMI to the blood flow signals of MCP and PIP synovial membrane in 230 joints was 17.83%, 16.96% respectively, the difference was not statistically significant (P>0.05); MCP was mainly expressed by the dorsal synovial blood flow signal, and the display rate was 63.41%, which was 33.33% higher than that of PIP high, PIP mainly showed the sacral synovial blood flow signal, the display rate was 53.85%, and the MCP volar display rate was 21.95%,the difference was statistically significant(P<0.05); there was no significant difference in the degree of involvement between MCP and PIP (P>0.05).Conclusion SMI technology can objectively evaluate MCP and PIP subclinical active inflammation in RA patients. MCP subclinical active inflammation is mainly distributed in the dorsal synovium, and PIP is mainly distributed in the palmar synovium.

参考文献/References:

[1]刘芳,朱家安,魏小雨,等.超微血流成像技术评估类风湿关节炎患者手指关节亚临床炎[J].中国医学影像技术,2016,32(5):663-666. [2]Aletaha D,Neogi T,Silman AJ,et al.2010 Rheumatoid arthritis classification criteria:An American College of Rheumatology/European League Against Rheumatism collaborative initiative[J].Arthritis Rheum,2010,62(9):2569-2581. [3]Lim AKP,Satchithananda K,Dick EA,et al.Microflow imaging:New Doppler technology to detect low-grade inflammation in patients with arthritis[J].Eur Radiol,2018,28(3):1046-1053. [4]Wenxue L,Fang L,Jiaan Z,et al.Superb microvascular imaging improving inflammatory flow blood sensitivity in patients with rheumatoid arthritis[J].Int J Clin Exp Med,2016(9):19930-19934. [5]Zabotti A,Salvin S,Quartuccio L,et al.Differentiation between early rheumatoid and early psoriatic arthritis by the ultrasono graphic study of the synovio-entheseal complex of the small joints of the hands[J].Clin Exp Rheumatol,2016,34(3):459-465. [6]Yoshimi R,Hama M,Takase K,et al.Ultrasonography is a potent tool for the prediction of progressive joint destruction during clinical remission of rheumatoid arthritis[J].Mod Rheumatol,2013,23(3):456-465. [7]Felson DT,Smolen JS,Wells G,et al.American College of Rheumatology/European League against Rheumatism procisional definition of remission inrheumatoid arthritis for clinical trials[J].Ann Rheum Dis,2011,70(3):404-413. [8]Meier R,Thuermel K,Noel PB,et al.Synovitis in patients with early inflammatory arthritis monitored with quantitative analysis of dynamic contrast－enhanced optical imaging and MR imaging[J].Radiology,2014,270(1):176-185. [9]孙宏,卢瑞刚,李硕,等.超微血管成像技术在类风湿性关节炎滑膜血管翳中的应用[J].中华医学超声杂志（电子版）,2016,13(4):254-257. [10]Fodor D,Felea I,Popescu D,et al.Ultrasounography of the metacarpophalangeal joints in healthy subjects using an 18 MHz transducer[J].Med Ultrason,2015,7(2):185-191. [11]Yokota K,Tsuzuki WT,Akiyama Y,et al.Detection of synovial inflammation in rheumatic diseases using superb microvascular imaging:Comparison with conventional power Doppler imaging[J].Mod Rheumatol,2018,28(2):327-333. [12]Cai XH,Yang SP,Shen HL,et al.Application of contrast enhances ultrasonography and ultrasonography scores in rheumatoid arthritis[J].Int J Clin Exp Med,2015,8(11):20056-20064. [13]张凌燕,向茜,唐远姣,等.类风湿性关节炎滑膜超声造影定量分析与临床及实验室检查指标的相关性研究[J].四川大学学报（医学版）,2014,45(6):1001-1004. [14]李丽,叶玉泉,陈京京,等.超微血管成像技术评估类风湿活动性关节炎:与CDFI和CEUS对比[J].中国医学影像技术,2016,32(10):1569-1571. [15]齐清华,王俊魁,周元媛,等.彩色超微血管成像技术对活动期类风湿关节炎的评估[J].中国临床医学影像杂志,2018,29(12):893-898.

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更新日期/Last Update: 2019-07-15