[1]范均熔,王庆东,曾凡荣.瑞芬太尼复合丙泊酚麻醉在腹腔镜远端胃癌D2根治术中的应用[J].医学信息,2020,33(04):136-138.[doi:10.3969/j.issn.1006-1959.2020.04.043]
　FAN Jun-rong,WANG Qing-dong,ZENG Fan-rong.Application of Remifentanil and Propofol Anesthesia in Laparoscopic DistalGastric Cancer D2 Radical Operation[J].Medical Information,2020,33(04):136-138.[doi:10.3969/j.issn.1006-1959.2020.04.043]
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瑞芬太尼复合丙泊酚麻醉在腹腔镜远端胃癌D2根治术中的应用()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年04期
页码:
136-138
栏目:
药物与临床
出版日期:
2020-02-15

文章信息/Info

Title:
Application of Remifentanil and Propofol Anesthesia in Laparoscopic DistalGastric Cancer D2 Radical Operation
文章编号:
1006-1959（2020）04-0136-03
作者:
范均熔; 王庆东; 曾凡荣
（佳木斯大学附属第一医院麻醉科，黑龙江 佳木斯 154000）
Author(s):
FAN Jun-rong; WANG Qing-dong; ZENG Fan-rong
(Department of Anesthesiology,the First Affiliated Hospital of Jiamusi University,Jiamusi 154000,Heilongjiang,China)
关键词:
瑞芬太尼; 丙泊酚; D2根治术; 麻醉质量
Keywords:
Remifentanil; Fentanyl; D2 radical operation; Quality of anaesthsia
分类号:
R614；R735.2
DOI:
10.3969/j.issn.1006-1959.2020.04.043
文献标志码:
A
摘要:
目的 探讨瑞芬太尼复合丙泊酚麻醉在腹腔镜远端胃癌D2根治术中的应用效果。方法 选取2017年10月1日~2019年10月1日我院收治的行腹腔镜远端胃癌D2根治术的进展期胃癌患者96例，采用随机数字表法分为观察组和对照组，每组48例，观察组采用瑞芬太尼复合丙泊酚麻醉，对照组采用芬太尼复合丙泊酚麻醉，比较两组麻醉效果，麻醉前（T0）、麻醉中（T1）、手术完毕时（T2）时心率（HR）、平均动脉压（MAP）、氧饱和度（SpO2）、皮质醇（COR）、白细胞介素-6（IL-6）、葡萄糖（GLU）及不良反应发生情况。结果 观察组麻醉总有效率为95.83%，高于对照组的75.00%，差异具有统计学意义（P＜0.05）；观察组T1、T2时间点HR低于对照组，MAP、SpO2高于对照组，差异具有统计学意义（P＜0.05）；观察组T1、T2时皮质COR、IL-6、GLU水平低于对照组，差异具有统计学意义（P＜0.05）；观察组麻醉后不良反应发生率为8.33%，低于对照组的22.92%，差异具有统计学意义（P＜0.05）。结论 瑞芬太尼复合丙泊酚麻醉在腹腔镜远端胃癌D2根治术中的应用效果良好，对患者血流动力学影响较小，患者生命体征平稳，且不良反应发生率较低。
Abstract:
Objective To investigate the effect of remifentanil combined with propofol anesthesia in laparoscopic distal gastric cancer D2 radical operation.Methods 96 patients with advanced gastric cancer who underwent laparoscopic distal gastric cancer D2 radical surgery who were treated in our hospital from October 1,2017 to October 1,2019 were divided into observation group and control group by random number table method,For each group of 48 patients,the observation group was anesthetized with remifentanil and propofol,and the control group was anesthetized with fentanyl and propofol.Compare the effects of anesthesia between two groups,before anesthesia (T0),during anesthesia(T1),at the completion of surgery(T2),heart rate(HR),mean arterial pressure (MAP),oxygen saturation(SpO2),cortisol(COR),Interleukin-6(IL-6),glucose(GLU)and incidence of adverse reactions.Results The total effective rate of anesthesia in the observation group was 95.83%, which was higher than 75.00% in the control group,the difference was statistically significant(P＜0.05).The HR at time points T1 and T2 in the observation group was lower than that in the control group,and MAP and SpO2 were higher than those in the control group,the difference was statistically significant(P＜0.05).The levels of COR, IL-6, and GLU in the observation group at T1 and T2 were lower than those in the control group,the differences were statistically significant(P＜0.05);the incidence of adverse reactions after anesthesia in the observation group was 8.33%,which was lower than that of 22.92% in the control group,the difference was statistically significant(P＜0.05).Conclusion Remifentanil combined with propofol anesthesia has a good effect in laparoscopic distal gastric cancer D2 radical surgery,with less effect on hemodynamics,stable vital signs,and fewer adverse reactions.

参考文献/References:

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更新日期/Last Update: 2020-02-15