[1]李美凤,李元海,夏晓琼.磷酸肌酸钠对难治性精神分裂症患者无抽搐电休克治疗后认知功能的影响[J].医学信息,2021,34(03):88-91,98.[doi:10.3969/j.issn.1006-1959.2021.03.025]
　LI Mei-feng,LI Yuan-hai,XIA Xiao-qiong.The Effect of Creatine Phosphate Sodium on the Cognitive Function of Patients with Refractory Schizophrenia After Modified Electroconvulsive Therapy[J].Medical Information,2021,34(03):88-91,98.[doi:10.3969/j.issn.1006-1959.2021.03.025]
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磷酸肌酸钠对难治性精神分裂症患者无抽搐电休克治疗后认知功能的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年03期
页码:
88-91,98
栏目:
论著
出版日期:
2021-02-01

文章信息/Info

Title:
The Effect of Creatine Phosphate Sodium on the Cognitive Function of Patients with Refractory Schizophrenia After Modified Electroconvulsive Therapy
文章编号:
1006-1959（2021）03-0088-05
作者:
李美凤; 李元海; 夏晓琼
（1.安徽医科大学附属巢湖医院麻醉科，安徽 巢湖 238000； 2.安徽医科大学第一附属医院麻醉科，安徽 合肥 230032）
Author(s):
LI Mei-feng; LI Yuan-hai; XIA Xiao-qiong
(1.Department of Anesthesiology,Chaohu Hospital,Anhui Medical University,Chaohu 238000,Anhui,China; 2.Department of Anesthesiology,the First Affiliated Hospital of Anhui Medical University,Hefei 230032,Anhui,China)
关键词:
无抽搐电休克治疗; 精神分裂症; 认知功能; 脑源性神经营养因子; 磷酸肌酸
Keywords:
Modified electroconvulsive therapy; Schizophrenia; Cognitive function; Brain-derived neurotrophic factor; Creatine phosphate
分类号:
R74
DOI:
10.3969/j.issn.1006-1959.2021.03.025
文献标志码:
A
摘要:
目的 探讨磷酸肌酸钠对难治性精神分裂症（TRS）患者无抽搐电休克（MECT）治疗后认知功能的影响。方法 选取2018年9月~2020年6月安徽医科大学附属巢湖医院精神科收住的难治性精神分裂症患者40例，采用随机数字表法分成磷酸肌酸钠组（CPS组）和对照组（C组），每组20例。CPS组在MECT治疗前静脉输注磷酸肌酸钠15 mg/kg（溶于100 ml生理盐水），C组输注等容量生理盐水，均30 min输注完毕，比较两组治疗前后阳性与阴性症状量表（PANSS）与重复性成套神经心理状态测验（RBANS）评分，及血清脑源性神经营养因子（BDNF）和C-反应蛋白（CRP）浓度水平。结果 治疗后，CPS组阴性症状评分和阳性症状评分均低于C组，RBANS评分总分和各子评分高于C组，差异有统计学意义（P＜0.05）；CPS组BDNF浓度、CRP浓度高于C组，差异有统计学意义（P＜0.05）。结论 磷酸肌酸钠对难治性精神分裂症患者MECT治疗后的认知功能具有改善作用，可提高BDNF浓度、CRP浓度。
Abstract:
Objective To investigate the effect of creatine phosphate sodium on the cognitive function of patients with refractory schizophrenia (TRS) after modified electroconvulsive therapy(MECT) treatment.Methods A total of 40 patients with refractory schizophrenia admitted to the Department of Psychiatry, Chaohu Hospital Affiliated to Anhui Medical University from September 2018 to June 2020 were selected.Using random number table method, they were divided into creatine phosphate sodium group (CPS group) and control group (C group), with 20 cases in each group.The CPS group received intravenous infusion of creatine phosphate 15 mg/kg (dissolved in 100 ml of normal saline) before MECT treatment, and the C group received an equal volume of normal saline. The infusion was completed within 30 min.The scores of the Positive and Negative Symptom Scale (PANSS) and the Repetitive Neuropsychological State Test (RBANS), and serum brain-derived neurotrophic factor (BDNF) and C-reactive protein (CRP) levels were compared between the two groups before and after treatment.Results After treatment, the negative symptom score and positive symptom score of CPS group were lower than those of group C, and the total score of RBANS score and each sub-score were higher than those of group C,the difference was statistically significant (P<0.05);The concentration of BDNF and CRP in the CPS group were higher than those in the C group,the difference was statistically significant (P<0.05).Conclusion Creatine phosphate sodium can improve the cognitive function of patients with refractory schizophrenia after MECT treatment, and can increase the concentration of BDNF and CRP.

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更新日期/Last Update: 1900-01-01