[1]薛 飞,赵颖海.TIM-3在常见肿瘤中的表达研究[J].医学信息,2022,35(17):173-176,180.[doi:10.3969/j.issn.1006-1959.2022.17.047]
 XUE Fei,ZHAO Ying-hai.Expression of TIM-3 in Common Tumors[J].Journal of Medical Information,2022,35(17):173-176,180.[doi:10.3969/j.issn.1006-1959.2022.17.047]
点击复制

TIM-3在常见肿瘤中的表达研究()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年17期
页码:
173-176,180
栏目:
综述
出版日期:
2022-09-01

文章信息/Info

Title:
Expression of TIM-3 in Common Tumors
文章编号:
1006-1959(2022)17-0173-05
作者:
薛 飞赵颖海
(广东医科大学病理系,广东 湛江 524023)
Author(s):
XUE FeiZHAO Ying-hai
(Department of Pathology,Guangdong MedicalUniversity,Zhanjiang 524023,Guangdong,China)
关键词:
肿瘤T细胞免疫球蛋白黏蛋白3肿瘤免疫免疫检查点
Keywords:
TumorT cell immunoglobulin mucin 3Tumor immunityImmune checkpoints
分类号:
R73
DOI:
10.3969/j.issn.1006-1959.2022.17.047
文献标志码:
A
摘要:
人体内存在多种免疫检查点,在免疫系统中起负性调节作用。T细胞免疫球蛋白黏蛋白3(TIM-3)是新发现的免疫检查点之一,在细胞免疫、先天免疫中起重要作用,且与肿瘤的发生发展相关。本文对不同实验技术方法检测常见肿瘤中TIM-3表达的状态及其意义作一综述,旨在帮助临床全面认识TIM-3。
Abstract:
There are a variety of immune checkpoints in the human body, which play a negative regulatory role in the immune system. T cell immunoglobulin mucin 3 (TIM-3) is one of the newly discovered immune checkpoints, which plays an important role in cellular immunity and innate immunity, and is related to the occurrence and development of tumor. This article reviews the status and significance of TIM-3 expression in common tumors detected by different experimental techniques, aiming to help clinical understanding of TIM-3.

参考文献/References:

[1]Das M,Zhu C,KuchrooVK.Tim-3 and its role in regulating anti-tumor immunity[J].Immunol Rev,2017,276(1):97-111.[2]Solinas C,de Silva P,Bron D,et al.Significance of TIM3 expression in cancer: from biology to the clinic[J].Semin Oncol,2019,46(4-5):372-379.[3]He YY,Cao J,Zhao C,et al.TIM-3, a promising target for cancer immunotherapy[J].Onco Targets Ther,2018,11:7005-7009.[4]Sheng CC,Han FY.Immunoregulation effects of TIM-3 on tumors[J].Neoplasma,2019,66(2):167-175.[5]Gao X,Zhu YB,Li G,et al.TIM-3 expression characterizes regulatory T cells in tumor tissues and is associated with lung cancer progression[J].PLoS One,2012,7(2):e30676.[6]吉芃,陈迪康,卞建叶,等.TIM-3在人非小细胞肺癌CD4+肿瘤浸润淋巴细胞的表达增强提示预后不良[J].细胞与分子免疫学杂志,2015,31(6):808-811.[7]Zhou GY,Sprengers D,Boor PPC,et al.Antibodies against immune checkpoint molecules restore functions of tumor-infiltrating T cellsin hepatocellular carcinomas[J].Gastroenterology,2017,153(4):1107-1119.[8]Takano S,Saito H,Ikeguchi M.An increased number of PD-1+ and Tim-3+ CD8+ T cells is involved in immune evasion in gastric cancer[J].Surg Today,2016,46(11):1341-1347.[9]Piao YR,Jin XS.Analysis of Tim-3 as a therapeutic target in prostate cancer[J].Tumour Biol,2017,39(7):1010428317716628.[10]Zhang W,Feng H,Chen QC,et al.The functional potency of natural killer cells in response to IL-2/IL-15/IL-21 stimulation is limited by a concurrent upregulation of Tim-3 in bladder cancer[J].Exp Cell Res,2018,372(2):92-98.[11]Li XE,Wang B,Gu LT,et al.Tim-3 expression predicts the abnormal innate immune status and poor prognosis of glioma patients[J].Clin Chim Acta,2018,476:178-184.[12]郑雨佳,杨惠雲,吴倩,等.Tim-3在食管癌患者T细胞表面的表达及其临床意义[J].中国肿瘤生物治疗杂志,2019,26(3):312-316.[13]Xu BL,Yuan L,Gao QL,et al.Circulating and tumor-infiltrating Tim-3 in patients with colorectal cancer[J].Oncotarget,2015,6(24):20592-20603.[14]Gravelle P,Do C,Franchet C,et al.Impaired functional responses in follicular lymphoma CD8+TIM-3+ T lymphocytes following TCR engagement[J].Oncoimmunology,2016,5(10):e1224044.[15]Li Z,Li N,Li F,et al.Immune checkpoint proteins PD-1 and TIM-3 are both highly expressed in liver tissues and correlate with their gene polymorphisms in patients with HBV-related hepatocellular carcinoma[J].Medicine (Baltimore),2016,95(52):e5749.[16]Wang YY,Wang SC,Zhu CC,et al.The association between immune characteristic and clinical pathology in Chinese patients with adenocarcinoma of esophagogastric junction[J].Cancer Manag Res,2020,12:3259-3269.[17]Liu ZJ,Han HM,He X,et al.Expression of the galectin-9-Tim-3 pathway in glioma tissues is associated with the clinical manifestations of glioma[J].Oncol Lett,2016,11(3):1829-1834.[18]Moore M,Ring KL,Mills AM.TIM-3 in endometrial carcinomas: an immunotherapeutic target expressed by mismatch repair-deficient and intact cancers[J].Mod Pathol,2019,32(8):1168-1179.[19]Curley J,Conaway MR,Chinn Z,et al.Looking past PD-L1:expression of immune checkpoint TIM-3 and its ligand galectin-9 in cervical and vulvar squamous neoplasia[J].Mod Pathol,2020,33(6):1182-1192.[20]Yu MM,Lu B,Liu YC,et al.Tim-3 is upregulated in human colorectal carcinoma and associated with tumor progression[J].Mol Med Rep,2017,15(2):689-695.[21]Sun QY,Qu CH,Liu JQ,et al.Down-regulated expression of Tim-3 promotes invasion and metastasis of colorectal cancer cells[J].Neoplasma,2017,64(1):101-107.[22]Wu JL,Lin GW,Zhu Y,et al.Low TIM3 expression indicates poor prognosis of metastatic prostate cancer and acts as an independent predictor of castration resistant status[J].Sci Rep,2017,7(1):8869.[23]Zhang XM,Yin XX,Zhang HR,et al.Differential expression of TIM-3 between primary and metastatic sites in renal cell carcinoma[J].BMC Cancer,2019,19(1):49.[24]Peng PJ,Li Y,Sun S.On the significance of Tim-3 expression in pancreatic cancer[J].Saudi J Biol Sci,2017,24(8):1754-1757.[25]郑雨佳,杨惠雲,吴倩,等.Tim-3在食管癌患者T细胞表面的表达及其临床意义[J].中国肿瘤生物治疗杂志,2019,26(3):312-316.[26]张季,邹陈蔚,仓慧,等.Tim-3在食管癌中的表达及其临床意义[J].胃肠病学,2020,25(9):540-543.[27]Quan HZ,Fang LJ,Pan H,et al.An adaptive immune response driven by mature, antigen-experienced T and B cells within the microenvironment of oral squamous cell carcinoma[J].Int J Cancer,2016,138(12):2952-2962.[28]Liu JF,Ma SR,Mao L,et al.T-cell immunoglobulin mucin 3 blockade drives an antitumor immune response in head and neck cancer[J].Mol Oncol,2017,11(2):235-247.[29]Cheng SQ,Han FY,Xu YQ,et al.Erratum: Expression of Tim-3 in breast cancer tissue promotes tumor progression[J].Int J Clin Exp Pathol,2021,14(7):855.[30]高锋,钱文霞,冯一中.非小细胞肺癌中TIM-3、PD-1、PD-L1的表达与临床意义[J].海南医学,2019,30(2):154-158.[31]Fang HY,YuanC,Gu XS,et al.TIM-3Association between polymorphisms and cancer risk:a meta-analysis[J].Ann Transl Med,2019,7:550.[32]Cui SJ,Li Y,Zhou RM,et al.TIM-3 polymorphism is involved in the progression of esophageal squamous cell carcinoma by regulating gene expression[J].Environ Mol Mutagen,2021,62(4):273-283.[33]Liu YB,Duan Y,Yang N,et al.The TIM-3 Rs10053538 polymorphism is associated with clinical prognosis of colorectal cancer[J].Immunol Invest,2022,51(5):1302-1312.[34]Wu JL,Zhao J,Zhang HB,et al.Genetic variants and expression of the TIM-3 gene are associated with clinical prognosis in patients with epithelial ovarian cancer[J].Gynecol Oncol,2020,159(1):270-276.[35]Cong YZ,Liu J,Chen G,et al.The emerging role of T-cell immunoglobulin mucin-3 in breast cancer: apromising target for immunotherapy[J].Front Oncol,2021,11:723238.[36]Saleh R,Taha RZ,Toor SM,et al.Expression of immune checkpoints and T cell exhaustion markers in early and advanced stages of colorectal cancer[J].CancerImmunolImmunother,2020,69(10):1989-1999.[37]沈辉,盛晗,陆建菊,等.程序性死亡受体1和T细胞免疫球蛋白黏蛋白分子3在乳腺癌肿瘤微环境中的表达、分布及其与临床病理特征的关系[J].中华医学杂志,2018,98(17):1352-1357.[38]Cao Y,Zhou XX,Huang XY,et al.Tim-3 expression in cervical cancer promotes tumor metastasis[J].PLoS One,2013,8(1):e53834.[39]郭艳,魏小娟,高琦.T细胞中Tim-3异常表达对胃癌进展的调控机制[J].中国老年学杂志,2021,41(21):4834-4837.[40]Chen BJ,Dashnamoorthy R,Galera P,et al.The immune checkpoint molecules PD-1, PD-L1, TIM-3 and LAG-3 in diffuse large B-cell lymphoma[J].Oncotarget,2019,10(21):2030-2040.[41]Sakuishi K,Apetoh L,Sullivan J,et al.Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity[J].J Exp Med,2011,208(6):1331.[42]Liu Y,Cai PC,Wang N,et al.Combined blockade of Tim-3 and MEK inhibitor enhances the efficacy against melanoma[J].Biochem Biophys Res Commun,2017,484(2):378-384.

相似文献/References:

[1]杨森果,毛大华,杨海松,等.E-cadherin与肿瘤侵袭、转移相关性研究进展[J].医学信息,2018,31(03):3.[doi:10.3969/j.issn.1006-1959.2018.04.002]
 YANG Sen-guo,MAO Da-hua,YANG Hai-song,et al.Research Progress of the Correlation between E-cadherin and Tumor Invasion and Metastasis[J].Journal of Medical Information,2018,31(17):3.[doi:10.3969/j.issn.1006-1959.2018.04.002]
[2]江立基,李先明.碳酸酐酶Ⅸ在肿瘤中的研究进展[J].医学信息,2018,31(03):7.[doi:10.3969/j.issn.1006-1959.2018.03.003]
 JIANG Li-ji,LI Xian-ming.Research Progress of Carbonic Anhydrase IX in Cancer[J].Journal of Medical Information,2018,31(17):7.[doi:10.3969/j.issn.1006-1959.2018.03.003]
[3]靳雪芹,邓正聪.代谢综合征与肿瘤关系的研究进展[J].医学信息,2018,31(05):35.[doi:10.3969/j.issn.1006-1959.2018.05.014]
 JIN Xue-qin,DENG Zheng-cong.Research Progress on the Relationship between Metabolic Syndrome and Tumor[J].Journal of Medical Information,2018,31(17):35.[doi:10.3969/j.issn.1006-1959.2018.05.014]
[4]白 雪,邓 琦.血液系统肿瘤的细胞治疗研究进展[J].医学信息,2018,31(10):41.[doi:10.3969/j.issn.1006-1959.2018.10.013]
 BAI Xue,DENG Qi.Advances in Cell Therapy for Blood System Tumor[J].Journal of Medical Information,2018,31(17):41.[doi:10.3969/j.issn.1006-1959.2018.10.013]
[5]李 轩,王子为,赵靖萱,等.肿瘤预后预测领域机器学习应用的文献计量与热点可视化分析[J].医学信息,2022,35(09):90.[doi:10.3969/j.issn.1006-1959.2022.09.023]
 LI Xuan,WANG Zi-wei,ZHAO Jing-xuan,et al.Visualization Analysis on Bibliometrics and Hot Spots of Machine Learning Applications in the Field of Tumor Prognosis Prediction[J].Journal of Medical Information,2022,35(17):90.[doi:10.3969/j.issn.1006-1959.2022.09.023]
[6]王 静,刘 梅,焦菊凤.知-信-行健康教育模式对PICC置管肿瘤 患者自我护理能力的影响[J].医学信息,2018,31(11):170.[doi:10.3969/j.issn.1006-1959.2018.11.056]
 WANG Jing,LIU Mei,JIAO Ju-feng.Effect of Knowledge-belief-behavioral Health Education Model on the Self-care Ability of Patients with Cancer in PICC Catheterization[J].Journal of Medical Information,2018,31(17):170.[doi:10.3969/j.issn.1006-1959.2018.11.056]
[7]史红娟,李群锋,赵 华,等.舒林酸抗肿瘤作用的研究进展[J].医学信息,2018,31(12):35.[doi:10.3969/j.issn.1006-1959.2018.12.012]
 SHI Hong-juan,LI Qun-feng,ZHAO Hua,et al.Advances in Research on Anti-tumor Effect of Sulindac[J].Journal of Medical Information,2018,31(17):35.[doi:10.3969/j.issn.1006-1959.2018.12.012]
[8]庞小坤,韩 梅,江心灿,等.当归补血汤治疗肿瘤化疗不良反应随机对照临床试验的Meta分析[J].医学信息,2019,32(02):69.[doi:10.3969/j.issn.1006-1959.2019.02.021]
 Pang Xiao-kun,Han Mei,Jiang Xin-can,et al.Meta-analysis of a Randomized Controlled Clinical Trial of Angelica Buxue Decoction in the Treatment of Adverse Reactions to Chemotherapy[J].Journal of Medical Information,2019,32(17):69.[doi:10.3969/j.issn.1006-1959.2019.02.021]
[9]张 慧,胡广越,殷 红.菌群干预与免疫治疗的研究进展[J].医学信息,2022,35(11):54.[doi:10.3969/j.issn.1006-1959.2022.11.016]
 ZHAHG Hui,HU Guang-yue,YIN Hong.Research Progress in Microbial Intervention and Immunotherapy[J].Journal of Medical Information,2022,35(17):54.[doi:10.3969/j.issn.1006-1959.2022.11.016]
[10]郑文灿,法艳梅,吕亚青,等.苦参碱抗肿瘤机制的分子生物学研究进展[J].医学信息,2018,31(19):51.[doi:10.3969/j.issn.1006-1959.2018.19.017]
 ZHENG Wen-can,FA Yan-mei,LV Ya-qing,et al.Advances in Molecular Biology of Matrine Antitumor Mechanism[J].Journal of Medical Information,2018,31(17):51.[doi:10.3969/j.issn.1006-1959.2018.19.017]

更新日期/Last Update: 1900-01-01