[1]杨晓旭,赵振宇.亚莫利联合二甲双胍对2型糖尿病的降糖效果观察[J].医学信息,2023,36(10):134-137.[doi:10.3969/j.issn.1006-1959.2023.10.029]
　YANG Xiao-xu,ZHAO Zhen-yu.Observation on Hypoglycemic Effect of Amaryl Combined with Metformin on Type 2 Diabetes Mellitus[J].Journal of Medical Information,2023,36(10):134-137.[doi:10.3969/j.issn.1006-1959.2023.10.029]
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亚莫利联合二甲双胍对2型糖尿病的降糖效果观察()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年10期
页码:
134-137
栏目:
论著
出版日期:
2023-05-15

文章信息/Info

Title:
Observation on Hypoglycemic Effect of Amaryl Combined with Metformin on Type 2 Diabetes Mellitus
文章编号:
1006-1959（2023）10-0134-04
作者:
杨晓旭; 赵振宇
（天津医科大学朱宪彝纪念医院药剂科，天津 300400）
Author(s):
YANG Xiao-xu; ZHAO Zhen-yu
(Department of Pharmacy,Tianjin Medical University Chu Hsien-I Memorial Hospital,Tianjin 300400,China)
关键词:
亚莫利; 二甲双胍; 2型糖尿病; 降糖效果
Keywords:
Amaryl;  Metformin; Type 2 diabetes mellitus; Hypoglycemic effect
分类号:
R587.1
DOI:
10.3969/j.issn.1006-1959.2023.10.029
文献标志码:
A
摘要:
目的 观察亚莫利联合二甲双胍对2型糖尿病的降糖效果。方法 采用随机数字表法将2020年4月-2021年4月在我院诊治的102例2型糖尿病患者分为对照组（n=51）和观察组（n=51），分别采用二甲双胍治疗及二甲双胍联合亚莫利治疗。比较两组临床疗效、血糖指标、胰岛β细胞功能指标、并发症发生率以及不良反应发生率。结果 观察组治疗总有效率为96.07%，高于对照组的84.31%（P＜0.05）；两组治疗后空腹血糖（FBG）、餐后2 h血糖（2 h PG）、糖化血红蛋白（HbA1c）水平均低于治疗前，且观察组低于对照组（P＜0.05）；两组治疗后胰岛素抵抗指数（HOMA-IR）均低于治疗前，胰岛β细胞功能指数（HOMA-β）均高于治疗前，且观察组HOMA-IR低于对照组，HOMA-β高于对照组（P＜0.05）；观察组并发症发生率为7.84%，低于对照组的17.64%（P＜0.05）；观察组不良反应发生率为5.88%，与对照组的7.84%比较，差异无统计学意义（P＞0.05）。结论 亚莫利联合二甲双胍治疗2型糖尿病具有确切的降糖效果，可促进空腹血糖、餐后2 h血糖水平降低，减轻机体胰岛素抵抗，改善胰岛功能，降低并发症发生率，且不会增加临床不良反应，是一种良好的治疗方案。
Abstract:
Objective To observe the hypoglycemic effect of amaryl combined with metformin on type 2 diabetes mellitus.Methods From April 2020 to April 2021, totally 102 patients with type 2 diabetes mellitus diagnosed and treated in our hospital were divided into control group (n=51) and observation group (n=51) by random number table method, and they were treated with metformin and metformin combined with amaryl respectively. The clinical efficacy, blood glucose index, islet β cell function index, complication rate and adverse reaction rate were compared between the two groups. Results The total effective rate of the observation group is 96.07%, which was higher than 84.31% of the control group (P<0.05). After treatment, the levels of fasting blood glucose (FBG), 2 h postprandial blood glucose (2 hPG) and glycosylated hemoglobin (HbA1c) in the two groups were lower than those before treatment, and those in the observation group were lower than those in the control group (P<0.05). The insulin resistance index (HOMA-IR) of the two groups was lower than that before treatment, and the islet β cell function index (HOMA-β) was higher than that before treatment, while the HOMA-IR of the observation group was lower than that of the control group, and the HOMA-β was higher than that of the control group (P<0.05). The incidence of complications in the observation group was 7.84%, which lower than 17.64% in the control group (P<0.05). The incidence of adverse reactions in the observation group was 5.88%, compared with 7.84% in the control group, the difference was not statistically significant (P>0.05).Conclusion Amaryl combined with metformin has a definite hypoglycemic effect in the treatment of type 2 diabetes mellitus, which can promote the decrease of fasting blood glucose and 2 h postprandial blood glucose, reduce insulin resistance, improve islet function, reduce the incidence of complications, and will not increase clinical adverse reactions. It is a good treatment plan.

参考文献/References:

[1]袁东平.亚莫利联合二甲双胍对2型糖尿病的降糖效果观察[J].白求恩医学杂志,2017,15(3):358-360.[2]蒋升.2017年ACP《2型糖尿病口服药物治疗临床实践指南》解读[J].中国全科医学,2017,20(33):4091-4095,4104.[3]汪菲,高向阳,张蓉,等.二甲双胍联合DPP-4抑制剂对比二甲双胍联合磺脲类药物对2型糖尿病患者心血管疾病风险、心血管相关死亡率和/或全因死亡率影响的荟萃分析[J].湖南师范大学学报(医学版),2017,14(6):16-21.[4]何明倩,王静雅,邓梅,等.西格列汀与格列美脲联合二甲双胍治疗初诊２型糖尿病并高糖毒性患者的有效性及安全性比较[J].西安交通大学学报(医学版),2021,42(1):86-88.[5]Rashid M,Shahzad M,Mahmood S,et al.Variability in the therapeutic response of Metformin treatment in patients with type 2 diabetes mellitus[J].Pak J Med Sci,2019,35(1):71-76.[6]李晋莹,李舸.二甲双胍单药疗效不佳的2型糖尿病患者联合达格列净或格列美脲治疗的效果及安全性观察[J].海南医学,2022,25(8):107-108.[7]中华医学会糖尿病学分会.中国2型糖尿病防治指南(2017年版)[J].中华糖尿病杂志,2018,10(1):64-67.[8]Blonde L,Patel C,Bookhart B,et al.A real-world analysis of glycemic control among patients with type 2 diabetes treated with canagliflozin versus dapagliflozin[J].Curr Med Res Opin,2018,34(6):1143-1152.[9]王佩,郑娅红,冯秒肖,等.阿司匹林联合格列美脲对2型糖尿病的临床疗效及对血清炎性因子的影响[J].中国老年学杂志,2019,7(5):124-125.[10]Kala P,Jamuna Rani R,Kumar JS,et al.A comparative study of efficacy and safety among metformin with sitagliptin,metformin with voglibose,and metformin with glimepiride in patients with type 2 diabetes mellitus[J].Innovare Academic Sciences,2017,10(12):314-316.[11]蒲丹岚,尹经霞,谢洁,等.复方盐酸吡格列酮格列美脲片与格列美脲片治疗2型糖尿病的疗效与安全性对照研究[J].重庆医学,2018,47(7):915-918.[12]林雯雯,王海静,张玉盼,等.格列美脲与格列本脲分别与沙格列汀、二甲双胍联用治疗2型糖尿病的有效性及经济性评价[J].中国老年学杂志,2019,39(12):5951-5953.[13]马雅辉,王立.胰岛素类似物取代人胰岛素联合口服降糖药对糖尿病患者用药量和C肽-胰岛素释放的影响[J].中南医学科学杂志,2016,44(3):296-298.[14]鲁平,任琢琢,张云.格列美脲治疗老年2型糖尿病安全性和有效性的临床观察[J].中华老年医学杂志,2016,35(10):1091-1093.[15]朱玮,杨春娟.格列美脲联合沙格列汀在2型糖尿病患者中的应用效果研究[J].山西医药杂志,2022,25(2):70-72.[16]冼炯超,廖理国,邵雅琴.格列美脲联合二甲双胍治疗老年人2型糖尿病的有效性分析[J].深圳中西医结合杂志,2021,30(7):53-55.[17]李超杰,陈慧敏,濮先明.利拉鲁肽、格列美脲分别联用二甲双胍治疗肥胖型2型糖尿病疗效观察[J].陕西医学杂志,2021,5(3):73-74.[18]那日苏,刘志文,马聪,等.格列美脲联合沙格列汀治疗2型糖尿病的疗效观察[J].现代药物与临床,2018,33(10):2585-2588.[19]杜群,楼雪勇.二甲双胍、格列美脲、胰岛素联用沙格列汀治2型糖尿病临床对照研究[J].中国农村卫生事业管理,2018,38(2):255-257.[20]李海燕,丁国强,贺强,等.甘精胰岛素联合格列美脲治疗在改善长期2型糖尿病患者血糖水平和药物耐受中的应用[J].临床和实验医学杂志,2018,17(2):162-166.

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更新日期/Last Update: 1900-01-01