[1]王海燕,毕雪玲,曹 晶,等.坤泰胶囊联合炔雌醇环丙孕酮片、二甲双胍治疗多囊卵巢综合征的效果及对性激素的影响[J].医学信息,2020,33(20):129-131.[doi:10.3969/j.issn.1006-1959.2020.20.039]
　WANG Hai-yan,BI Xue-ling,CAO Jing,et al.The Effect of Kuntai Capsule Combined with Ethinyl Estradiol and Cyproterone Tablets and Metformin in the Treatment of Polycystic Ovary Syndrome and Its Influence on Sex Hormones[J].Medical Information,2020,33(20):129-131.[doi:10.3969/j.issn.1006-1959.2020.20.039]
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坤泰胶囊联合炔雌醇环丙孕酮片、二甲双胍治疗多囊卵巢综合征的效果及对性激素的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年20期
页码:
129-131
栏目:
药物与临床
出版日期:
2020-10-15

文章信息/Info

Title:
The Effect of Kuntai Capsule Combined with Ethinyl Estradiol and Cyproterone Tablets and Metformin in the Treatment of Polycystic Ovary Syndrome and Its Influence on Sex Hormones
文章编号:
1006-1959（2020）20-0129-03
作者:
王海燕; 毕雪玲; 曹 晶; 等
（1.西安交通大学第一附属医院生殖医学科，陕西 西安 710061； 2.延安市人民医院妇产科，陕西 延安 716000）
Author(s):
WANG Hai-yan; BI Xue-ling; CAO Jing; et al
(1.Department of Reproductive Medicine,the First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061,Shaanxi,China; 2.Department of Obstetrics and Gynecology,Yan’an People’s Hospital,Yan’an 716000,Shaanxi,China)
关键词:
坤泰胶囊; 炔雌醇环丙孕酮片; 二甲双胍; 多囊卵巢综合征; 性激素
Keywords:
Kuntai capsule; Ethinyl estradiol and cyproterone tablets; Metformin; Polycystic ovary syndrome; Sex hormones
分类号:
R711.75
DOI:
10.3969/j.issn.1006-1959.2020.20.039
文献标志码:
A
摘要:
目的 研究坤泰胶囊联合炔雌醇环丙孕酮片和二甲双胍治疗多囊卵巢综合征的临床效果。方法 选取2018年1月~2019年1月我院诊治的160例多囊卵巢综合征患者为研究对象，采用随机数字表法分为对照组和观察组，各80例。对照组采用炔雌醇环丙孕酮片联合二甲双胍治疗，观察组在对照组基础上联合坤泰胶囊治疗，比较两组临床治疗总有效率、性激素[黄体激素（LH）、促卵泡激素（FSH）、睾酮（T）、雌激素（E2）]水平、子宫内膜厚度、成熟卵泡数、排卵率、妊娠率以及不良反应发生情况。结果 观察组治疗总有效率为96.25%，高于对照组的82.50%（P＜0.05）；治疗后，两组LH、FSH、T水平均低于治疗前，E2均高于治疗前，且观察组LH、FSH、T水平低于对照组，E2高于对照组（P＜0.05）；观察组子宫内膜厚度、成熟卵泡数均大于对照组（P＜0.05）；观察组排卵率为92.50%、妊娠率为16.25%，均高于对照组的81.25%、10.00%（P＜0.05）；观察组不良反应发生率6.25%与对照组5.00%比较，差异无统计学意义（P＞0.05）。结论 坤泰胶囊联合炔雌醇环丙孕酮片和二甲双胍治疗多囊卵巢综合征可提高临床治疗效果，促进性激素水平改善，增厚子宫内膜，增加成熟卵泡数量，进一步提升排卵率和妊娠率，且不会增加不良反应，安全性良好。
Abstract:
Objective To study the clinical effect of Kuntai capsule combined with ethinyl estradiol and cyproterone tablets and metformin in the treatment of polycystic ovary syndrome.Methods A total of 160 patients with polycystic ovary syndrome diagnosed and treated in our hospital from January 2018 to January 2019 were selected as the research objects. They were divided into a control group and an observation group by random number table method, with 80 cases in each group. The control group was treated with ethinyl estradiol and cyproterone tablets combined with metformin, and the observation group was treated with Kuntai capsule on the basis of the control group. The total effective rate of clinical treatment, sex hormones [luteinizing hormone (LH), follicle stimulating hormone (FSH), testosterone (T), estrogen (E2)] levels, endometrial thickness, number of mature follicles, ovulation rate, pregnancy rate, and adverse reactions.Results The total effective rate of treatment in the observation group was 96.25%, which was higher than 82.50% in the control group(P＜0.05). After treatment, the levels of LH, FSH and T in the two groups were lower than before treatment, and E2 was higher than before treatment. The levels of LH, FSH and T in the observation group were lower than those in the control group, and E2 was higher than the control group(P<0.05); the endometrial thickness and the number of mature follicles in the observation group were greater than those in the control group(P<0.05); the observation group’s ovulation rate was 92.50%, and the pregnancy rate was 16.25% , Both were higher than 81.25% and 10.00% of the control group (P<0.05); the adverse reaction rate of the observation group was 6.25% compared with the control group 5.00%, the difference was not statistically significant (P>0.05).Conclusion Kuntai capsule combined with ethinyl estradiol and cyproterone tablets and metformin in the treatment of polycystic ovary syndrome could improve the clinical treatment effect, promote the improvement of sex hormone levels, thicken the endometrium, increase the number of mature follicles, and further increase the ovulation rate and pregnancy rate,and will not increase adverse reactions, with good safety.

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更新日期/Last Update: 1900-01-01