[1]郑丽华.高通量血液透析对尿毒症患者的钙磷代谢、微炎症状态及尿素透析充分性的影响[J].医学信息,2023,36(11):99-101,113.[doi:10.3969/j.issn.1006-1959.2023.11.018]
　ZHENG Li-hua.Effects of High Flux Hemodialysis on Calcium and Phosphorus Metabolism,Microinflammatory State and Urea Dialysis Adequacy in Uremic Patients[J].Journal of Medical Information,2023,36(11):99-101,113.[doi:10.3969/j.issn.1006-1959.2023.11.018]
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高通量血液透析对尿毒症患者的钙磷代谢、微炎症状态及尿素透析充分性的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年11期
页码:
99-101,113
栏目:
论著
出版日期:
2023-06-01

文章信息/Info

Title:
Effects of High Flux Hemodialysis on Calcium and Phosphorus Metabolism,Microinflammatory State and Urea Dialysis Adequacy in Uremic Patients
文章编号:
1006-1959（2023）11-0099-04
作者:
郑丽华
（玉山黄家驷医院/玉山县人民医院内分泌科，江西 玉山 334700）
Author(s):
ZHENG Li-hua
(Department of Endocrinology,Huangjiasi Hospital/Yushan People’s Hospital,Yushan 334700,Jiangxi,China)
关键词:
高通量血液透析; 尿毒症; 钙磷代谢微炎症; 尿素
Keywords:
High flux hemodialysis; Uremia; Calcium-phosphorus metabolism microinflammation; Urea
分类号:
R692.5
DOI:
10.3969/j.issn.1006-1959.2023.11.018
文献标志码:
A
摘要:
目的 研究高通量血液透析对尿毒症患者的钙磷代谢、微炎症状态及尿素透析充分性的影响。方法 选取2020年1月-2022年1月在我院诊治的84例尿毒症患者为研究对象，采用随机数字表法分为对照组和观察组，各42例。对照组采用低通量血液透析，观察组实施高通量血液透析，比较两组血钙水平、血磷水平、炎症因子指标水平、尿素透析充分性指标、肾功能指标以及并发症发生率。结果 两组治疗后血钙水平均高于治疗前，血磷水平均低于治疗前，且观察组血钙水平高于对照组，血磷水平低于对照组（P＜0.05）；两组治疗后超敏-C反应蛋白（hs-CRP）、白细胞介素6（IL-6）均低于治疗前，且观察组低于对照组（P＜0.05）；观察组尿素清除指数（Kt/V）均高于对照组（P＜0.05）；两组治疗后血肌酐（SCr）、血清尿素氮（BUN）均低于治疗前，且观察组低于对照组（P＜0.05）；观察组并发症发生率为7.14%，低于对照组16.67%（P＜0.05）。结论 高通量血液透析对尿毒症患者的钙磷代谢微炎症状具有积极的影响，可改善血钙、血磷水平，抑制微炎反应，改善肾功能，降低并发症发生率，提高尿素透析充分性，相对具有更优的应用优势。
Abstract:
Objective To study the effects of high flux hemodialysis on calcium and phosphorus metabolism, microinflammatory state and urea dialysis adequacy in uremia patients.Methods A total of 84 uremic patients diagnosed and treated in our hospital from January 2020 to January 2022 were selected as the research objects. They were divided into control group and observation group by random number table method, with 42 cases in each group. The control group was treated with low flux hemodialysis, and the observation group was treated with high flux hemodialysis. The blood calcium level, blood phosphorus level, inflammatory factor index level, urea dialysis adequacy index, renal function index and complication rate were compared between the two groups.Results After treatment, the blood calcium levels of the two groups were higher than those before treatment, and the blood phosphorus levels were lower than those before treatment, while the blood calcium level of the observation group was higher than that of the control group, and the blood phosphorus level was lower than that of the control group (P<0.05). After treatment, the levels of hypersensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6) in the two groups were lower than those before treatment, and those in the observation group were lower than those in the control group (P<0.05). The urea clearance index (Kt/V) in the observation group was higher than that in the control group (P<0.05). After treatment, serum creatinine (SCr) and serum urea nitrogen (BUN) in the two groups were lower than those before treatment, and those in the observation group were lower than those in the control group (P<0.05). The incidence of complications in the observation group was 7.14%, which was lower than 16.67% in the control group (P<0.05).Conclusion High flux hemodialysis has a positive effect on the calcium-phosphorus metabolism microinflammation in uremic patients, which can improve blood calcium and phosphorus levels, inhibit micro-inflammatory reactions, improve renal function, reduce the incidence of complications, and improve urea dialysis adequacy. It has relatively better application advantages.

参考文献/References:

[1]张俊,王新美,赵霞,等.高通量血液透析对尿毒症患者血清磷及高敏C反应蛋白、白蛋白、前白蛋白、转铁蛋白的影响分析[J].中国地方病防治杂志,2017,32(7):729,732.[2]王丽丽,王莉华,高永宁,等.尿毒症维持性血液透析合并肺部 感染患者血清NGAL和 MMP-9的表达水平[J].中华医院感染学杂志,2020,30(12):1835-1839. [3]唐玲,邓晓风,代青,等.高通量血液透析对尿毒症患者心肌损伤标志物和心功能指标的影响[J].中华危重病急救医学,2017,29(6):547-550.[4]王云,顾毅峰.血液透析滤过治疗老年尿毒症对其肾功能影响情况研究[J].国际泌尿系统杂志,2018,38(3):460-463.[5]唐俊,左满花,黄德斌.不同血液净化模式对终末期肾病患者的自身免疫、炎症应激及生活质量的影响[J].中国现代医学杂志,2017,27(28):22-28.[6]龚豪,黄丽,张庆红,等.高通量血液透析和血液透析滤过对慢性肾功能衰竭患者临床疗效、肾功能及毒素清除率的影响[J].解放军医药杂志,2019,31(8):62-65.[7]章凌云.尿毒症血液透析患者并发脑出血28例单中心临床观察[J].中国急救复苏与灾害医学杂志,2020,15(3):304-306. [8]张妮.高通量血液透析对老年尿毒症患者钙磷代谢异常的影响[J].吉林医学,2020,41(8):1951-1952. [9]宋培.血液灌流联合血液透析对尿毒症患者肾功能及T淋巴细胞水平的影响[J].河北医学,2019,25(8):1253-1257.[10]肖克君,刘建.高通量维持性血液透析对CRF患者血清钙、磷、甲状旁腺激素的影响及安全性分析[J].山东医药,2017,57(44):66-68.[11]徐芳,聂大庆,黎莉,等.罗伐他汀对血液透析患者微炎症状态及血脂的影响[J].实用医学杂志,2017,33(16):2740-2743. [12]Allawi AAD.Malnutrition,inflamation and athero- sclerosis (MIA syndrome) in patients with end stage renal disease on maintenance hemodialysis (a single centre experience)[J].Diabetes Metab Syndr,2018,12(2):91-97.[13]Liang KV,Zhang JH,Palevsky PM.Urea reduction ratio may be a simpler approach for measurement of adequacy of intermittent hemodialysis in acute kidney injury[J].BMC Nephrol,2019,20(1):82.[14]高伟,杨雄,李小芳.高通量血液透析对维持性血液透析患者生存质量影响[J].贵州医药,2021,45(9):1411-1412.[15]刘继红,弓晓丽,张利霞.高通量透析对尿毒症患者炎性因子及血脂代谢的影响[J].中国药物与临床,2019,19(24):4373-4374.[16]田媚.西那卡塞联合小剂量骨化三醇治疗终末期肾脏病继发性甲状旁腺功能亢进的疗效分析[J].安徽医药,2018,22(6):1163-1166.[17]周燚,郭晓燕,余春华,等.长期高通量血液透析联合血液灌流对维持性血液透析患者血脂代谢的影响[J].宁夏医学杂志,2018,40(3):271-273.[18]王冰.高通量血液透析对终末期肾衰患者营养状况及肾性贫血状况的影响[J].陕西医学杂志,2019,48(6):766-769.

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更新日期/Last Update: 1900-01-01