[1]栾晓倩,门丽影,姚慧霞,等.血浆D-二聚体、PDW与左心房内径联合预测非瓣膜性房颤左心房血栓形成的价值[J].医学信息,2023,36(23):50-54.[doi:10.3969/j.issn.1006-1959.2023.23.012]
　LUAN Xiao-qian,MEN Li-ying,YAO Hui-xia,et al.Predictive Value of Plasma D-dimer, PDW Combined with Left Atrial Diameter for Left Atrial Thrombosis in Patients with Atrial Fibrillation[J].Journal of Medical Information,2023,36(23):50-54.[doi:10.3969/j.issn.1006-1959.2023.23.012]
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血浆D-二聚体、PDW与左心房内径联合预测非瓣膜性房颤左心房血栓形成的价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年23期
页码:
50-54
栏目:
论著
出版日期:
2023-12-01

文章信息/Info

Title:
Predictive Value of Plasma D-dimer, PDW Combined with Left Atrial Diameter for Left Atrial Thrombosis in Patients with Atrial Fibrillation
文章编号:
1006-1959（2023）23-0050-05
作者:
栾晓倩; 门丽影; 姚慧霞; 等
（1.石河子大学医学院，新疆 石河子 832000；2.石河子大学医学院第一附属医院心血管内科，新疆 石河子 832000）
Author(s):
LUAN Xiao-qian; MEN Li-ying; YAO Hui-xia; et al.
(1.Shihezi University School of Medicine,Shihezi 832000,Xinjiang,China;2.Department of Cardiology,the First Affiliated Hospital of Shihezi University School of Medicine,Shihezi 832000,Xinjiang,China)
关键词:
心房颤动; 左心房血栓; D-二聚体; 血小板分布宽度; 左心房内径
Keywords:
Atrial fibrillation; Left atrial thrombus; D-dimer; Platelet distribution width; Left atrial diameter
分类号:
R541.7+5
DOI:
10.3969/j.issn.1006-1959.2023.23.012
文献标志码:
A
摘要:
目的 探讨D-二聚体、血小板分布宽度（PDW）、左心房内径联合对非瓣膜性房颤患者左心房血栓形成的预测价值。方法 纳入2019年6月-2022年6月于石河子大学医学院第一附属医院就诊并行TEE检查的非瓣膜性房颤患者103例，根据TEE检查结果将患者分为血栓组（15例）和对照组（88例）。比较两组临床指标[D-二聚体、纤维蛋白原降解产物（FDP）、PDW、左心房内径、左室舒张末内径]，并采用单因素及多因素Logistic回归分析影响血栓形成的因素，绘制ROC曲线分析其对血栓形成的预测价值。结果 两组左室舒张末内径比较，差异无统计学意义（P＞0.05）；血栓组D-二聚体、FDP、PDW、左心房内径均高于对照组，差异有统计学意义（P＜0.05）；D-二聚体、PDW、左心房内径为非瓣膜性房颤形成的危险因素，三者联合预测血栓的ROC曲线下面积（AUC）为0.824[95%CI（0.719，0.930）]，灵敏度为80.00%，特异度为83.00%。结论 D-二聚体、PDW、左心房内径三者联合检测对非瓣膜性房颤患者左心房血栓形成有较高的预测价值。
Abstract:
Objective To investigate the predictive value of D-dimer, platelet distribution width (PDW) and left atrial diameter combined with left atrial thrombosis in patients with non-valvular atrial fibrillation.Methods A total of 103 patients with non-valvular atrial fibrillation who underwent TEE examination in the First Affiliated Hospital of Shihezi University School of Medicine from June 2019 to June 2022 were included. According to the results of TEE examination, the patients were divided into thrombus group (15 patients) and control group (88 patients). The clinical indexes [D-dimer, fibrinogen degradation products (FDP), PDW, left atrial diameter, left ventricular end-diastolic diameter] were compared between the two groups. Univariate and multivariate Logistic regression analysis was used to analyze the factors affecting thrombosis, and ROC curve was drawn to analyze its predictive value for thrombosis.Results There was no significant difference in left ventricular end-diastolic diameter between the two groups (P>0.05). The D-dimer, FDP, PDW and left atrial diameter in the thrombus group were higher than those in the control group, and the differences were statistically significant (P<0.05). D-dimer, PDW, and left atrial diameter were risk factors for non-valvular atrial fibrillation. The area under the ROC curve ( AUC ) of the combined prediction of thrombosis was 0.824[95%CI(0.719,0.930)], the sensitivity was 80.00%, and the specificity was 83.00%.Conclusion The combined detection of D-dimer, PDW and left atrial diameter has a high predictive value for left atrial thrombosis in patients with non-valvular atrial fibrillation.

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更新日期/Last Update: 1900-01-01