[1]杨庆玲.血清C肽与糖化血红蛋白联合检验对糖尿病患者病情辅助诊断的价值[J].医学信息,2024,37(02):146-148,152.[doi:10.3969/j.issn.1006-1959.2024.02.030]
　YANG Qing-ling.Value of Combined Test of Serum C Peptide and Glycosylated Hemoglobin in the Auxiliary Diagnosis of Diabetic Mellitus Patients[J].Journal of Medical Information,2024,37(02):146-148,152.[doi:10.3969/j.issn.1006-1959.2024.02.030]
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血清C肽与糖化血红蛋白联合检验对糖尿病患者病情辅助诊断的价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年02期
页码:
146-148,152
栏目:
论著
出版日期:
2024-01-15

文章信息/Info

Title:
Value of Combined Test of Serum C Peptide and Glycosylated Hemoglobin in the Auxiliary Diagnosis of Diabetic Mellitus Patients
文章编号:
1006-1959（2024）02-0146-04
作者:
杨庆玲
（金溪县人民医院检验科，江西 金溪 344800）
Author(s):
YANG Qing-ling
(Department of Clinical Laboratory,Jinxi County People’s Hospital,Jinxi 344800,Jiangxi,China)
关键词:
血清C肽; 糖化血红蛋白; 糖尿病
Keywords:
Serum C-peptide; Glycated hemoglobin; Diabetes mellitus
分类号:
R587.1
DOI:
10.3969/j.issn.1006-1959.2024.02.030
文献标志码:
A
摘要:
目的 研究血清C肽与糖化血红蛋白联合检验对糖尿病患者病情辅助诊断的价值。方法 选取2020年3月-2023年1月我院诊治的46例糖尿病患者作为观察组，另选取同期我院体检健康者46例作为对照组，比较观察组和对照组及观察组中合并和未合并并发症糖尿病患者血糖水平及血清C肽水平，并分析不同指标对糖尿病的诊断效能，以及血清C肽、糖化血红蛋白与糖尿病并发症的关系。结果 观察组空腹血糖、餐后2 h血糖水平均高于对照组（P＜0.05）；观察组血清C肽水平低于对照组，糖化血红蛋白水平高于对照组（P＜0.05）；血清C肽+糖化血红蛋白检测诊断糖尿病敏感度、特异度均高于血清C肽、糖化血红蛋白检测（P＜0.05），而血清C肽与糖化血红蛋白检测诊断敏感度、特异度比较，差异无统计学意义（P＞0.05）；合并并发症糖尿病患者血清C肽低于未合并并发症糖尿病患者，糖化血红蛋白水平高于未合并并发症糖尿病患者（P＜0.05）；Pearson相关性分析显示，糖尿病并发症与血清C肽呈负相关（r=-0.686，P＜0.05），与糖化血红蛋白呈正相关（r=0.562，P＜0.05）。结论 血清C肽与糖化血红蛋白糖尿病患者病情的发展具有密切关系，联合检验可提高糖尿病患者诊断效能，并且辅助临床一定程度判断血糖水平、病情进展以及是否合并并发症，为糖尿病诊治和糖尿病并发症预防提供可靠的参考依据。
Abstract:
Objective To study the value of combined test of serum C peptide and glycosylated hemoglobin in the auxiliary diagnosis of diabetic mellitus patients.Methods From March 2020 to January 2023, forty-six diabetic patients diagnosed and treated in our hospital from were selected as the observation group, and during the same period, 46 healthy people who underwent physical examination in our hospital were selected as the control group. The blood glucose levels and serum C-peptide levels in the control group and the observation group, as well as the diabetic patients with and without complications were compared, and the diagnostic efficacy of different indicators for diabetes was analyzed, as well as the relationship between serum C-peptide, glycosylated hemoglobin and diabetic complications.Results The levels of fasting blood glucose and 2 h postprandial blood glucose in the observation group were higher than those in the control group (P<0.05). The level of serum C peptide in the observation group was lower than that in the control group, and the level of glycosylated hemoglobin was higher than that in the control group (P<0.05). The sensitivity and specificity of serum C peptide+glycosylated hemoglobin in the diagnosis of diabetes mellitus were higher than those of serum C peptide and glycosylated hemoglobin (P<0.05), but there was no significant difference in the sensitivity and specificity between serum C peptide and glycosylated hemoglobin (P>0.05). The level of serum C peptide in patients with diabetes mellitus complicated with complications was lower than that in patients without diabetes mellitus complicated with complications, and the level of glycosylated hemoglobin was higher than that in patients without diabetes mellitus complicated with complications (P<0.05). Pearson correlation analysis showed that diabetic complications were negatively correlated with serum C-peptide (r=-0.686, P<0.05) and positively correlated with glycosylated hemoglobin (r=0.562, P<0.05).Conclusion Serum C-peptide and glycosylated hemoglobin are closely related to the development of diabetic mellitus patients. The combined test can improve the diagnostic efficacy of diabetic mellitus patients, and assist the clinical judgment of blood glucose level, disease progression and complications to a certain extent, and provide a reliable reference for the diagnosis and treatment of diabetes mellitus and the prevention of diabetic complications.

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更新日期/Last Update: 1900-01-01