[1]陈方圆,刘永梅.系统免疫炎症指数与慢性肾脏病患者预后的相关性[J].医学信息,2024,37(05):143-148.[doi:10.3969/j.issn.1006-1959.2024.05.026]
　CHEN Fang-yuan,LIU Yong-mei.Correlation Between Systemic Immune Inflammatory Index and Prognosis of Patients with Chronic Kidney Disease[J].Journal of Medical Information,2024,37(05):143-148.[doi:10.3969/j.issn.1006-1959.2024.05.026]
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系统免疫炎症指数与慢性肾脏病患者预后的相关性()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年05期
页码:
143-148
栏目:
论著
出版日期:
2024-03-01

文章信息/Info

Title:
Correlation Between Systemic Immune Inflammatory Index and Prognosis of Patients with Chronic Kidney Disease
文章编号:
1006-1959（2024）05-0143-06
作者:
陈方圆; 刘永梅
（安徽医科大学附属巢湖医院肾脏内科，安徽 合肥 238000）
Author(s):
CHEN Fang-yuan; LIU Yong-mei
(Department of Nephrology,Chaohu Hospital of Anhui Medical University,Hefei 238000,Anhui,China)
关键词:
系统免疫炎症指数; 慢性肾脏病; 预后
Keywords:
Systemic immune inflammation index; Chronic kidney disease; Prognosis
分类号:
R473
DOI:
10.3969/j.issn.1006-1959.2024.05.026
文献标志码:
A
摘要:
目的 探讨系统免疫炎症指数（SII）与慢性肾脏病（CKD）患者预后的相关性。方法 回顾性分析2017年1月-2019年1月安徽医科大学附属巢湖医院肾脏内科收治的174例CKD患者的临床资料，计算SII数值。根据SII水平将患者分为低SII组（SII≤450.68）和高SII组（SII＞450.68），比较两组临床资料，并通过Kaplan-Meier生存曲线分析两组中位肾脏生存时间，采用单因素和多因素Cox回归模型分析CKD患者预后的影响因素。结果 高SII组的CKD4期和5期比例、WBC、Plt、24 h尿蛋白定量、Scr、BUN、CycC及PA高于低SII组，而Alb低于低SII组，差异有统计学意义（P＜0.05）。Kaplan-Meier生存曲线分析显示，高SII组中位肾脏生存期短于低SII组（25.83个月vs. 67.61个月，P＜0.05）。单因素分析显示，CKD分期、高血压、糖尿病、贫血、24 h尿蛋白定量、UA、TG、SII均是CKD患者预后的影响因素（P＜0.05）。多因素分析显示，CKD分期、贫血、24 h尿蛋白定量、UA、SII均是影响CKD患者预后的独立危险因素（P＜0.05）。结论 SII与CKD患者预后有一定的相关性，高水平SII可能提示CKD患者预后不良。
Abstract:
Objective To investigate the correlation between systemic immune inflammation index (SII) and prognosis of patients with chronic kidney disease (CKD).Methods The clinical data of 174 patients with CKD admitted to the Department of Nephrology, Chaohu Hospital of Anhui Medical University from January 2017 to January 2019 were retrospectively analyzed, and the SII value was calculated. According to the level of SII, the patients were divided into low SII group (SII≤450.68) and high SII group (SII>450.68), and the clinical data of the two groups were compared. The median renal survival time of the two groups was compared by Kaplan-Meier survival curve. Univariate and multivariate Cox regression models were used to analyze the prognostic factors of patients with CKD.Results The proportion of CKD stage 4 and 5, WBC, Plt, 24-hour urinary protein quantity, Scr, BUN, CycC and PA in the high SII group were higher than those in the low SII group, while Alb was lower than that in the low SII group, and the differences were statistically significant (P<0.05). Kaplan-Meier survival curve analysis showed that the median renal survival in the high SII group was shorter than that in the low SII group (25.83 months vs. 67.61 months, P<0.05). Univariate analysis showed that CKD stage, hypertension, diabetes, anemia, 24-hour urinary protein quantity, UA, TG, and SII were all influencing factors for the prognosis of CKD patients (P<0.05). Multivariate analysis showed that CKD stage, anemia, 24-hour urinary protein quantity, UA and SII were independent risk factors affecting the prognosis of CKD patients (P<0.05).Conclusion There is a certain correlation between SII and the prognosis of patients with CKD. High level of SII may indicate poor prognosis of patients with CKD.

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更新日期/Last Update: 1900-01-01