[1]唐艳红,苏梅贵.Keap1-Nrf2-ARE信号通路与糖尿病视网膜病变的相关性研究进展[J].医学信息,2024,37(10):189-192.[doi:10.3969/j.issn.1006-1959.2024.10.041]
 TANG Yan-hong,SU Mei-gui.Research Progress on the Relationship Between Keap1-Nrf2-ARE Signaling Pathway and Diabetic Retinopathy[J].Journal of Medical Information,2024,37(10):189-192.[doi:10.3969/j.issn.1006-1959.2024.10.041]
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Keap1-Nrf2-ARE信号通路与糖尿病视网膜病变的相关性研究进展()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年10期
页码:
189-192
栏目:
综述
出版日期:
2024-05-15

文章信息/Info

Title:
Research Progress on the Relationship Between Keap1-Nrf2-ARE Signaling Pathway and Diabetic Retinopathy
文章编号:
1006-1959(2024)10-0189-04
作者:
唐艳红苏梅贵
(临夏州中医医院眼科,甘肃 临夏 731400)
Author(s):
TANG Yan-hongSU Mei-gui
(Department of Ophthalmology,Linxia State Hospital of Traditional Chinese Medicine,Linxia 731400,Gansu,China)
关键词:
Keap1-Nrf2-ARE信号通路糖尿病视网膜病变氧化应激
Keywords:
Keap1-Nrf2-ARE signaling pathwayDiabetic retinopathyOxidative stress
分类号:
R774
DOI:
10.3969/j.issn.1006-1959.2024.10.041
文献标志码:
A
摘要:
糖尿病视网膜病变(DR)是糖尿病并发症中最常见的微血管病变,是我国糖尿病(DM)患者视力下降甚至致盲的主要原因。近年来研究发现,氧化应激是DR的发病机制之一,而Kelch样环氧氯丙烷相关蛋白-1(Keap1)-核因子E2相关因子2(Nrf2)-抗氧化反应元件(ARE)信号通路是机体最重要的内源性抗氧化应激通路。故本文就Keap1-Nrf2-ARE信号通路与氧化应激、DR之间的相关性作一综述。
Abstract:
Diabetic retinopathy (DR) is the most common microvascular disease among diabetic complications, and it is the main cause of vision loss and even blindness in patients with diabetes mellitus (DM) in our country. In recent years, it has been found that oxidative stress is one of the pathogenesis of DR, and Kelch-like epichlorohydrin related protein-1 (Keap1)-nuclear factor E2 related factor 2 (Nrf2)-antioxidant response element (ARE) signaling pathway is the most important endogenous anti-oxidative stress pathway. Therefore, this article reviews the correlation between Keap1-Nrf2-ARE signaling pathway and oxidative stress and DR.

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更新日期/Last Update: 1900-01-01