[1]曾宪铭,黄丽芸,陈 娟,等.肺表面活性物质在新生儿呼吸窘迫综合征接受机械通气治疗中的应用效果及安全性[J].医学信息,2024,37(22):90-93.[doi:10.3969/j.issn.1006-1959.2024.22.022]
　ZENG Xianming,HUANG Liyun,CHEN Juan,et al.Application Effect and Safety of Pulmonary Surfactant in Mechanical Ventilation Treatment of Neonatal Respiratory Distress Syndrome[J].Journal of Medical Information,2024,37(22):90-93.[doi:10.3969/j.issn.1006-1959.2024.22.022]
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肺表面活性物质在新生儿呼吸窘迫综合征接受机械通气治疗中的应用效果及安全性()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年22期
页码:
90-93
栏目:
论著
出版日期:
2024-11-15

文章信息/Info

Title:
Application Effect and Safety of Pulmonary Surfactant in Mechanical Ventilation Treatment of Neonatal Respiratory Distress Syndrome
文章编号:
1006-1959（2024）22-0090-04
作者:
曾宪铭; 黄丽芸; 陈 娟; 涂愈旺; 李 智
全南县人民医院儿科，江西 全南 341800
Author(s):
ZENG Xianming; HUANG Liyun; CHEN Juan; TU Yuwang; LI Zhi
Pediatrics Department of Quannan County People’s Hospital,Quannan 341800, Jiangxi,China
关键词:
肺表面活性物质; 新生儿; 呼吸窘迫综合征; 机械通气
Keywords:
Pulmonary surfactant; Newborn; Respiratory distress syndrome; Mechanical ventilation
分类号:
R563.1
DOI:
10.3969/j.issn.1006-1959.2024.22.022
摘要:
目的 观察肺表面活性物质在新生儿呼吸窘迫综合征接受机械通气治疗中的应用效果及安全性。方法 选取2022年1月-2023年9月在我院诊治的68例新生儿呼吸窘迫综合征患儿为研究对象，采用随机数字表法分为常规组和试验组，各组34例。常规组患儿接受机械通气治疗，试验组给予机械通气+肺表面活性物质治疗。比较两组治疗效果、血气指标、并发症发生率、机械通气时间及住院时间。结果 试验组治疗总有效率（97.06%）高于常规组（85.29%）（P＜0.05）；两组治疗后PaO2、pH、PaO2/FiO2均高于治疗前，PaCO2均低于治疗前，且试验组PaO2、pH、PaO2/FiO2均高于常规组，PaCO2均低于常规组（P＜0.05）；试验组并发症发生率与常规组比较，差异无统计学意义（P＞0.05)；试验组机械通气时间、住院时间均短于常规组（P＜0.05)。结论 新生儿呼吸窘迫综合征采用肺表面活性物质与机械通气治疗可实现理想的治疗效果，提高总有效率，改善血气治疗，促进通气改善，缩短治疗进程，且无显著并发症，值得临床应用。
Abstract:
Objective To observe the application effect and safety of pulmonary surfactant in the treatment of neonatal respiratory distress syndrome with mechanical ventilation.Methods A total of 68 children with neonatal respiratory distress syndrome diagnosed and treated in our hospital from January 2022 to September 2023 were selected as the research objects. They were divided into routine group and experimental group (n=34) by random number table method. The routine group was treated with mechanical ventilation, and the experimental group was treated with pulmonary surfactant on the basis of the routine group. The therapeutic effect, blood gas indexes [arterial partial pressure of oxygen (PaO2), arterial partial pressure of carbon dioxide (PaCO2), pH, inhaled oxygen concentration (PaO2/FiO2)], incidence of complications, mechanical ventilation time and hospitalization time were compared between the two groups.Results The total effective rate of treatment in the experimental group (97.06%) was higher than that in the routine group (85.29%) (P<0.05). After treatment, PaO2, pH and PaO2/FiO2 in the two groups were higher than those before treatment, PaCO2 was lower than that before treatment, and PaO2, pH and PaO2/FiO2 in the experimental group were higher than those in the routine group, PaCO2 was lower than that in the routine group (P<0.05). There was no significant difference in the incidence of complications between the experimental group and the routine group (P>0.05). The mechanical ventilation time and hospitalization time of the experimental group were shorter than those of the routine group (P<0.05).Conclusion Pulmonary surfactant and mechanical ventilation in the treatment of neonatal respiratory distress syndrome can achieve the ideal therapeutic effect, improve the total effective rate, improve blood gas treatment, promote ventilation improvement, shorten the treatment process, and have no significant complications, which is worthy of clinical application.

参考文献/References:

[1]黎首豪,黄书炜,蔡玉青.新生儿急性呼吸窘迫综合征治疗中肺表面活性物质的疗效[J].中国医药科学,2020,10(1):166-168.[2]Cond V,Cipr Iani S,Colnaghi M,et al.Neonatal respiratory distress syndrome: are risk factors the same in preterm and terminfants[J].J Matern Fetal Neonatal Med,2017,30(11):1267-1272.[3]蒋惠芬,赵勇,王金秀.肺表面活性物质联合肺保护通气策略治疗新生儿重型胎粪吸入综合征合并急性肺损伤的疗效观察[J].实用临床医药杂志,2017,21(21):22-24.[4]封成芳,陈宏琼,许全珍,等.重度急性呼吸窘迫综合征新生儿的临床诊疗与生存状况研究[J].中国妇幼保健,2020,22(1):77-82.[5]徐明灯,刘汉青.肺泡表面活性物质联合机械通气治疗新生儿呼吸窘迫综合征的效果观察[J].中国医药科学,2018,8(10):72-74..[6]邢凯慧,王琦,宋依瑾,等.高频振荡通气联合肺表面活性剂治疗新生儿急性呼吸窘迫综合征的效果及对氧合功能的影响[J].中华实用诊断与治疗杂志,2019,33(9):895-898．[7]刘敏,王玲莉,郑凤.不同时间点应用肺表面活性物质与经鼻持续气道正压通气联合治疗对早产儿呼吸窘迫综合征疗效的影响[J].安徽医学,2017,38(8):1045-1048．[8]林报忠,郑通喜,蒋波,等.肺表面活性物质联合双水平气道正压通气治疗新生儿呼吸窘迫综合征的临床疗效[J].实用心脑肺血管病杂志,2017,25(7):77-80．[9]聂振清,陈晓燕.机械通气联合不同肺表面活性物质在新生儿呼吸窘迫综合征中的价值[J].安徽医药,2019,23(6):1222-1225．[10]黄方,陈霞,饶绘.高频振荡通气联合肺表面活性物质治疗新生儿呼吸窘迫综合征[J].川北医学院学报,2017,32(3):332-335.[11]黄进洁,闫玉琴,吴俊,等.经鼻机械通气联合肺表面活性物质治疗新生儿呼吸窘迫综合征疗效观察[J].海南医学,2019,30(17):2252-2254．[12]黄霞,赵德育,王全,等.肺炎支原体肺炎与肺表面活性物质相关蛋白 A 的相关性研究[J].南京医科大学学报(自然科学版),2017,37(6):719-722．[13]常明,卢红艳,相虹,等.不同机械通气方式联合肺表面活性剂对新生儿急性呼吸窘迫综合征呼吸力学的影响[J].实用医学杂志,2017,33(6):916-919．[14]林伟斌.肺表面活性物质联合CPAP治疗对新生儿呼吸窘迫综合征血气指标的影响[J].临床肺科杂志,2017,22(1):102-104.[15]刘东梅,席康明,柴建春,等.肺表面活性物质治疗对呼吸窘迫综合征新生儿肺功能的影响[J].武警后勤学院学报,2017,26(8):673-675.[16]李菲,刘小亮.持续正压通气联合肺表面活性物质治疗呼吸窘迫综合征效果及对新生儿安全性临床研究[J].陕西医学杂志,2019,48(1):52-54.[17]李俊燕.肺表面活性物质联合经鼻导管高流量加温湿化正压通气治疗新生儿呼吸窘迫综合征的临床疗效[J].中国处方药,2017,15(9):124-125.[18]马宁宁,王进.NCPAP联合肺表面活性物质治疗新生儿呼吸窘迫综合征[J].深圳中西医结合杂志,2019,29(2):164-166.[19]张金玉.大剂量肺表面活性物质联合无创正压通气治疗新生儿呼吸窘迫综合征的效果[J].河南医学研究,2019,28(2):311-312.[20]郑肖瑾.高频震荡通气联合肺泡表面活性物质治疗新生儿呼吸窘迫综合征的临床研究[J].检验医学与临床,2018,15(4):549-551.

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更新日期/Last Update: 1900-01-01