[1]徐洪兰,彭云香.血清γ-谷氨酰转肽酶水平与冠状动脉病变严重程度的关系[J].医学信息,2024,37(22):94-97.[doi:10.3969/j.issn.1006-1959.2024.22.023]
　XU Honglan,PENG Yunxiang.Relationship Between Serum γ-glutamyl Transpeptidase Level and Severity of Coronary Artery Disease[J].Journal of Medical Information,2024,37(22):94-97.[doi:10.3969/j.issn.1006-1959.2024.22.023]
点击复制

血清γ-谷氨酰转肽酶水平与冠状动脉病变严重程度的关系()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年22期
页码:
94-97
栏目:
论著
出版日期:
2024-11-15

文章信息/Info

Title:
Relationship Between Serum γ-glutamyl Transpeptidase Level and Severity of Coronary Artery Disease
文章编号:
1006-1959（2024）22-0094-04
作者:
徐洪兰1; 彭云香2
1.天津大学医院检验科，天津 300354；2.天津市第五中心医院检验科，天津 300450
Author(s):
XU Honglan1; PENG Yunxiang2
1.Department of Laboratory,Tianjin University Hospital,Tianjin 300354,China;2.Department of Laboratory,Tianjin Fifth Central Hospital,Tianjin 300354,China
关键词:
血清γ-GGT; 冠心病; 冠状动脉病变程度; Gensini评分
Keywords:
Serum γ-GGT; Coronary heart disease; Degree of coronary artery lesion; Gensini score
分类号:
R541.4
DOI:
10.3969/j.issn.1006-1959.2024.22.023
摘要:
目的 研究血清γ-谷氨酰转肽酶水平与冠状动脉病变严重程度的关系。方法 选取2021年5月-2022年5月在天津市第五中心医院经冠状动脉造影确诊的63例冠心病患者为观察组，并选取同期该院体检健康者60名为对照组。比较两组γ-GGT水平、不同病变血管支数（单支、双支、3支以上）冠心病患者Gensini评分和γ-GGT水平、不同Gensini评分（＜41分、41~80分、＞80分）冠状动脉病变患者γ-GGT水平、不同Gensini评分患者单因素分析、多因素Logistic回归分析Gensini评分危险因素，以及γ-GGT与Gensini评分的相关性。结果 观察组γ-GGT水平高于对照组（P＜0.05）。单支、双支，以及3支以上冠状动脉病变患者γ-GGT水平和Gensini评分均高于对照组，且3支以上患者高于单支、双支病变患者，双支患者高于单支病变患者（P＜0.05）。Gensini评分＞80分冠心病患者γ-GGT水平高于评分＜41分及41~80分患者，且41~80分患者高于评分＜41分患者（P＜0.05）。不同Gensini评分患者性别、合并症、病程比较，差异无统计学意义（P＞0.05）；年龄、病变血管支数比较，差异有统计学意义（P＜0.05）。多因素Logistic回归分析，γ-GGT水平、年龄、病变血管支数是Gensini评分危险因素。γ-GGT水平与Gensini评分呈正相关（P＜0.05）。结论 γ-GGT参与冠心病的发生与发展，检测γ-GGT水平可一定程度评估冠状动脉病变程度，且随病变血管支数增加而升高。同时γ-GGT水平与Gensini评分呈正相关，进一步为临床判断冠心病病情提供参考依据。
Abstract:
Objective To study the relationship between serum γ-glutamyl transpeptidase level and the severity of coronary artery disease.Methods A total of 63 patients with coronary heart disease diagnosed by coronary angiography in Tianjin Fifth Central Hospital from May 2021 to May 2022 were selected as the observation group, and 60 healthy people in the same period were selected as the control group. The levels of γ-GGT, Gensini scores and γ-GGT levels in patients with coronary heart disease with different number of diseased vessels (single, double, and more than 3 vessels), γ-GGT levels in patients with coronary artery disease with different Gensini scores (<41 scores, 41-80 scores, ＞80 scores), univariate analysis and multivariate logistic regression analysis the risk factors of patients with different Gensini scores, and the correlation between γ-GGT and Gensini score were compared between the two groups.Results The γ-GGT level in the observation group was higher than that in the control group (P<0.05). The γ-GGT level and Gensini score in patients with single, double and more than 3 coronary artery lesions were higher than those in the control group, and those in patients with more than 3 coronary artery lesions were higher than those in patients with single and double coronary artery lesions, and those in patients with double coronary artery lesions were higher than those in patients with single coronary artery lesions (P<0.05). The γ-GGT level in patients with coronary heart disease with Gensini score >80 scores was higher than that in patients with Gensini score <41 scores and 41-80 scores, and that in patients with Gensini score 41-80 scores was higher than that in patients with Gensini score <41 scores (P<0.05). There was no significant difference in gender, complications and course of disease among patients with different Gensini scores (P>0.05). There were statistically significant differences in age and number of diseased vessels (P<0.05). Multivariate Logistic regression analysis showed that γ-GGT level, age and number of diseased vessels were risk factors for Gensini score. The level of γ-GGT was positively correlated with Gensini score (P<0.05).Conclusion γ-GGT is involved in the occurrence and development of coronary heart disease. The detection of γ-GGT level can evaluate the degree of coronary artery disease to a certain extent, and increases with the increase of the number of diseased vessels. At the same time, the level of γ-GGT was positively correlated with Gensini score, which further provided a reference for clinical judgment of coronary heart disease.

参考文献/References:

[1]何汉康,叶巍,陈剑,等.血清脑钠尿肽、氨基末端脑钠尿肽前体、血管紧张素(1-7)水平与急性冠状动脉综合征患者心功能和预后的关系[J].中华高血压杂志,2020,28(5):470-474.[2]付熠,彭湘杭,何兰芬,等.NLR、IAI与急性冠脉综合征病人冠状动脉病变程度的关系[J].中西医结合心脑血管病杂志,2021,19(5):815-817.[3]王乐,周玉杰,丛洪良,等.血清γ-谷氨酰转移酶水平与老年冠心病患者经皮冠状动脉介入治疗后远期死亡率的关系[J].中国循环杂志,2018,33(9):864-868.[4]Faxén J,Xu H,Evans M,et al.Potassium levels and risk of inhospital arrhythmias and mortality in patients admitted with suspected acute coronary syndrome[J].Int J Cardiol,2019,1(274):52-58.[5]穆利英,熊筱伟,郭彩霞,等.急性冠脉综合征患者B型钠尿肽与冠状动脉病变程度的相关性分析[J].医学研究杂志,2020,49(4):135-138,144.[6]Fracassi F,Niccoli G,Vetrugno V,et al.Optical coherence tomography and Creactive protein in risk stratification of acute coronary syndromes[J].Int J Cardiol,2019,1(286):7-12.[7]陈彬,马智会,张永军,等.急性冠脉综合征病人血清胱抑素C、Hcy水平与冠状动脉病变程度的相关性分析[J].中西医结合心脑血管病杂志,2018,16(14):106-108.[8]袁宁,刘雅,彭春梅,等.冠心病患者血清尿酸水平与冠状动脉病变程度的相关性研究[J].四川医学,2017,38(12):1392-1396.[9]张燕妮.老年冠心病患者冠脉病变严重程度与血清UA及Hcy水平的相关性[J].心血管康复医学杂志,2017,26(4):391-394.[10]Sarkar NC,Sarkar P,Sarkar P,et al.Association of Coronary Heart Disease and CRP - as a Noble Marker of Inflammation A Case Control Study[J].J Assoc Physicians India,2019,67(10):54-56.[11]汪蕾,蔡濛,张萍.老年患者冠心病危险程度与血浆同型半胱氨酸及尿酸水平的相关研究[J].心肺血管病杂志,2017,36(8):629-632.[12]张培培,孙魁,刘爱萍,等.老年冠心病患者同型半胱氨酸、尿酸与冠状动脉狭窄及左心功能的相关性探讨[J].临床和实验医学杂志,2017,16(3):221-225.[13]宋家卫,李华,陆洪涛.脂蛋白ａ、胱抑素C与冠状动脉病变严重程度的相关性[J].蚌埠医学院学报,2017,42(8):1042-1044.[14]张放,安浩君,李霞,等.冠心病患者血清γ-谷氨酰转肽酶水平与Gensini评分的相关性研究[J].中国全科医学,2017,17(35):4166-4169.[15]李霞,程曼丽,纪玉强,等.胱抑素C水平与冠心病患者冠状动脉病变程度的关系[J].岭南心血管病杂志,2017,23(6):681-684.[16]赵秋兰,代江娜,刘霄岩,等.老年冠心病患者血清尿酸、Cysc及γ-GGT的水平及其与冠状动脉病变程度的相关性探究[J].国际检验医学杂志,2020,10(5):1206-1210.[17]Bian LQ,Zhang ZY,Kim SJ,et al.Gamma glutamyl transferase as a novel marker of coronary artery calcifica tion in women[J].J Cardiovasc Med ( Hagerstown),2018,13(11):684-690.[18]迟令福,张峰,张丽媛.γ谷氨酰转肽酶与冠心病的相关性研究[J].中华老年心脑血管病杂志,2019,21(9):981-983.[19]鞠丹丹,张玥,国莉莉,等.ACS患者血清GGT、BNP及CRP水平与冠状动脉病变程度的关系[J].分子诊断与治疗杂志,2022,14(1):137-140.[20]胡啸吟,陈悦,杨娇.老年冠心病患者颈动脉内膜中层厚度及血清γ-谷氨酰转肽酶与冠状动脉病变程度的关系[J].山西医药杂志,2018,45(11):2483-2496.

相似文献/References:

[1]袁 帅,邢晓博,李 晓,等.MTHFR基因多态性与中年男性冠状动脉病变程度的相关研究[J].医学信息,2018,31(03):67.[doi:10.3969/j.issn.1006-1959.2018.03.021]
　YUAN Shuai,XING Xiao-bo,LI Xiao,et al.Association of MTHFR Gene Polymorphism with Coronary Artery Lesions in Middle-aged Men[J].Journal of Medical Information,2018,31(22):67.[doi:10.3969/j.issn.1006-1959.2018.03.021]
[2]张挺挺.经股和桡动脉介入治疗冠心病的临床疗效对比[J].医学信息,2018,31(03):114.[doi:10.3969/j.issn.1006-1959.2018.03.038]
　ZHANG Ting-ting.Comparison of Clinical Effects of Interventional Treatment of Coronary Heart Disease by Femoral and Radial Artery[J].Journal of Medical Information,2018,31(22):114.[doi:10.3969/j.issn.1006-1959.2018.03.038]
[3]迮艳华.稳心颗粒联合美托洛尔治疗冠心病心律失常的疗效分析[J].医学信息,2018,31(03):139.[doi:10.3969/j.issn.1006-1959.2018.03.049]
　ZE Yan-hua.Therapeutic Effect of Wenxin Granule Combined with Metoprolol on Arrhythmia of Coronary Heart Disease[J].Journal of Medical Information,2018,31(22):139.[doi:10.3969/j.issn.1006-1959.2018.03.049]
[4]张 旭.冠心病心绞痛患者进行护理干预的临床效果及 对护理质量影响研究[J].医学信息,2018,31(05):182.[doi:10.3969/j.issn.1006-1959.2018.05.068]
　ZHANG Xu.Clinical Effect of Nursing Intervention in Patients with Angina Pectoris of Coronary Heart Disease and its Influence on Nursing Quality[J].Journal of Medical Information,2018,31(22):182.[doi:10.3969/j.issn.1006-1959.2018.05.068]
[5]向明明,赵晓辉.黑龙江省东部地区汉族人群冠心病的危险因素研究[J].医学信息,2018,31(07):122.[doi:10.3969/j.issn.1006-1959.2018.07.041]
　XIANG Ming-ming,ZHAO Xiao-hui.Study on Risk Factors of Coronary Heart Disease in Han Nationality Population in Eastern Heilongjiang Province[J].Journal of Medical Information,2018,31(22):122.[doi:10.3969/j.issn.1006-1959.2018.07.041]
[6]王 坤,张永春.血清胆红素水平、单核细胞数、红细胞分布宽度与 冠状动脉病变程度的关系[J].医学信息,2018,31(08):53.[doi:10.3969/j.issn.1006-1959.2018.08.017]
　WANG Kun,ZHANG Yong-chun.Relationship between Serum Bilirubin Level,Monocyte Count,Red Blood Cell Distribution Width and Severity of Coronary Artery Disease[J].Journal of Medical Information,2018,31(22):53.[doi:10.3969/j.issn.1006-1959.2018.08.017]
[7]毛红岩.冠状动脉介入治疗冠心病的疗效及 对患者血清炎症因子的影响[J].医学信息,2018,31(10):77.[doi:10.3969/j.issn.1006-1959.2018.10.023]
　MAO Hong-yan.Effect of Coronary Intervention on Coronary Heart Disease and its Influence on Serum Inflammatory Factors[J].Journal of Medical Information,2018,31(22):77.[doi:10.3969/j.issn.1006-1959.2018.10.023]
[8]杨锦龙,刘 欢,吕秋菊,等.非糖尿病患者糖化血红蛋白和胰岛素抵抗与 冠状动脉病变程度的相关性研究[J].医学信息,2018,31(10):93.[doi:10.3969/j.issn.1006-1959.2018.10.028]
　YANG Jin-long,LIU Huan,LV Qiu-ju,et al.Correlation between Glycosylated Hemoglobin and Insulin Resistance and Severity of Coronary Artery Disease in Non-diabetic Patients[J].Journal of Medical Information,2018,31(22):93.[doi:10.3969/j.issn.1006-1959.2018.10.028]
[9]李 铎,王建华.盐酸曲美他嗪片辅助治疗对冠心病伴心力衰竭患者氧化应激、心肌功能的影响[J].医学信息,2018,31(10):126.[doi:10.3969/j.issn.1006-1959.2018.10.041]
　LI Duo,WANG Jian-hua.Effect of Trimetazidine Hydrochloride Tablets Adjuvant Therapy on Oxidative Stress and Myocardial Function in Patients with Coronary Heart Disease Complicated with Heart Failure[J].Journal of Medical Information,2018,31(22):126.[doi:10.3969/j.issn.1006-1959.2018.10.041]
[10]宫丽萍.血府逐瘀汤加减治疗气滞血瘀型冠心病心绞痛的疗效研究[J].医学信息,2018,31(12):145.[doi:10.3969/j.issn.1006-1959.2018.12.046]
　GONG Li-ping.Therapeutic Effect of Xuefu Zhuyu Decoction on Angina Pectoris with Qi Stagnation and Blood Stasis[J].Journal of Medical Information,2018,31(22):145.[doi:10.3969/j.issn.1006-1959.2018.12.046]

更新日期/Last Update: 1900-01-01