[1]颜银花,张 博,杨镇宇,等.IL-1β和MMP-9在急性缺血性脑卒中血管再通后出血转化的表达水平及意义[J].医学信息,2025,38(01):91-95100.[doi:10.3969/j.issn.1006-1959.2025.01.016]
　YAN Yinhua,ZHANG Bo,YANG Zhenyu,et al.Expression and Significance of IL-1β and MMP-9 in Hemorrhagic Transformation After Recanalization in Acute Ischemic Stroke[J].Journal of Medical Information,2025,38(01):91-95100.[doi:10.3969/j.issn.1006-1959.2025.01.016]
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IL-1β和MMP-9在急性缺血性脑卒中血管再通后出血转化的表达水平及意义()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
38卷
期数:
2025年01期
页码:
91-95100
栏目:
论著
出版日期:
2025-01-01

文章信息/Info

Title:
Expression and Significance of IL-1β and MMP-9 in Hemorrhagic Transformation After Recanalization in Acute Ischemic Stroke
文章编号:
1006-1959（2025）01-0091-06
作者:
颜银花1; 2; 张 博1; 2; 杨镇宇1; 2; 谢嘉惠1; 2; 唐 淼1; 2; 龙 琼1; 2; 涂鄂文2
1.湖南中医药大学临床医学院，湖南 长沙 410208；2.湖南省脑科医院/湖南省第二人民医院神经内科，湖南 长沙 410007
Author(s):
YAN Yinhua1; 2;  ZHANG Bo1; 2;  YANG Zhenyu1; 2;  XIE Jiahui1; 2;  TANG Miao1; 2;  LONG Qiong1; 2;  TU Ewen2
1.College of Clinical Medical, Hunan University of Chinese Medicine, Changsha 410208, Hunan, China; 2.Department of Neurology, Brain Hospital of Hunan Province/the Second Hospital of Hunan Province, Changsha 410007, Hunan, China
关键词:
IL-1β; MMP-9; 急性缺血性脑卒中; 血管再通; 出血转化
Keywords:
IL-1β;  MMP-9;  Acute ischemic stroke;  Recanalization;  Hemorrhagic transformation
分类号:
R743.32
DOI:
10.3969/j.issn.1006-1959.2025.01.016
文献标志码:
A
摘要:
目的 探讨白介素-1β（IL-1β）及基质金属蛋白酶-9（MMP-9）在急性缺血性脑卒中（AIS）血管再通后出血转化（HT）的表达水平及意义。方法 选择2022年10月-2023年7月长沙市中心医院神经内科收治的45例AIS并接受血管再通治疗患者，根据影像学证据将其分为HT组（20例）和NHT组（25例）。比较两组患者临床基线资料、美国国立卫生研究院脑卒中量表（NIHSS）评分和改良Rankin量表（mRS）评分，分别在治疗前、血管再通治疗后24 h和第7天检测血清IL-1β、MMP-9水平。使用受试者工作特征曲线（ROC）评估血清IL-1β和MMP-9对AIS患者血管再通治疗后出血转化的预测价值。结果 两组基线资料及治疗方式比较，差异无统计学意义（P＞0.05）。HT组第7天的NIHSS评分及第90天的mRS评分高于NHT组（P＜0.05）。NHT组血清IL-1β水平在接受血管再通治疗后24 h达峰，随后下降，而HT组血清IL-1β水平呈持续升高趋势，且在第7天高于NHT组（P＜0.05）。HT组和NHT组血清MMP-9水平均在接受血管再通治疗后24 h达峰，随后下降，均高于治疗前水平；在接受血管再通治疗后24 h和第7天，HT组血清MMP-9水平高于NHT组（P＜0.05）。IL-1β水平对AIS血管再通后出血转化无预测价值；ROC曲线显示，血管再通治疗后24 h的血清MMP-9水平预测出血转化的曲线下面积（AUC）为0.728，最佳截断值是2241.59 μg/ml。结论 IL-1β和MMP-9在AIS血管再通后出血转化患者中显著升高；血清MMP-9水平对AIS血管再通后出血转化有一定的预测价值，可能成为出血转化诊断的潜在生物标志物。
Abstract:
Objective To investigate the expression and significance of interleukin-1β (IL-1β) and matrix metalloproteinase-9 (MMP-9) in hemorrhagic transformation (HT) after vascular recanalization in acute ischemic stroke (AIS). Methods Forty-five patients with AIS admitted to the Department of Neurology, Changsha Central Hospital from October 2022 to July 2023 and treated with vascular recanalization were selected and divided into HT group (20 patients) and NHT group (25 patients) according to imaging evidence. The clinical baseline data, National Institutes of Health Stroke Scale (NIHSS) score and modified Rankin Scale (mRS) score were compared between the two groups. The levels of serum IL-1β and MMP-9 were detected before treatment, 24 hours and 7 days after recanalization. The receiver operating characteristic curve (ROC) was used to evaluate the predictive value of serum IL-1β and MMP-9 for HT after vascular recanalization in AIS patients. Results There was no significant difference in baseline data and treatment methods between the two groups (P>0.05). The NIHSS score on the 7th day and the mRS score on the 90th day in the HT group were higher than those in the NHT group (P<0.05). The serum IL-1β level in the NHT group reached the peak at 24 h after vascular recanalization, and then decreased, while the serum IL-1β level in the HT group continued to increase, and was higher than that in the NHT group on the 7th day (P<0.05). The levels of serum MMP-9 in HT group and NHT group reached the peak at 24 h after vascular recanalization, and then decreased, which were higher than those before treatment. At 24 h and 7 days after recanalization, the serum MMP-9 level in HT group was higher than that in NHT group (P<0.05). The level of IL-1β had no predictive value for HT after AIS vascular recanalization. ROC curve showed that the area under the curve (AUC) of serum MMP-9 level at 24 h after recanalization for predicting HT was 0.728, and the optimal cut-off value was 2241.59 μg/ml. Conclusion IL-1β and MMP-9 are significantly increased in patients with hemorrhagic transformation after AIS vascular recanalization; the serum MMP-9 level has a certain predictive value for HT after AIS vascular recanalization, and may be a potential biomarker for HT diagnosis.

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更新日期/Last Update: 1900-01-01