[1]易 璐.头孢曲松钠对腹腔镜胆囊切除术患者术后感染的预防作用[J].医学信息,2025,38(03):141-144.[doi:10.3969/j.issn.1006-1959.2025.03.028]
　YI Lu.Preventive Effect of Ceftriaxone Sodium on Postoperative Infection in Patients Undergoing Laparoscopic Cholecystectomy[J].Journal of Medical Information,2025,38(03):141-144.[doi:10.3969/j.issn.1006-1959.2025.03.028]
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头孢曲松钠对腹腔镜胆囊切除术患者术后感染的预防作用()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
38卷
期数:
2025年03期
页码:
141-144
栏目:
论著
出版日期:
2025-02-01

文章信息/Info

Title:
Preventive Effect of Ceftriaxone Sodium on Postoperative Infection in Patients Undergoing Laparoscopic Cholecystectomy
文章编号:
1006-1959（2025）03-0141-04
作者:
易 璐
宜春新建医院药剂科，江西 宜春 336000
Author(s):
YI Lu
Pharmacy Department of Yichun Xinjian Hospital, Yichun 336000, Jiangxi, China
关键词:
头孢曲松钠; 腹腔镜; 胆囊切除术; 术后感染
Keywords:
Ceftriaxone sodium;  Laparoscopy;  Cholecystectomy;  Postoperative infection
分类号:
R619
DOI:
10.3969/j.issn.1006-1959.2025.03.028
文献标志码:
A
摘要:
目的 研究头孢曲松钠对腹腔镜胆囊切除术患者术后感染的预防作用。方法 依据随机数字表法将2020年2月-2023年2月我院诊治的62例腹腔镜胆囊切除术患者分为对照组和观察组，各组31例。对照组采用注射用头孢呋辛钠预防，观察组采用注射头孢曲松钠预防，比较两组术后感染发生率、临床恢复指标（体温恢复、白细胞计数恢复、肛门排气以及住院时间）、不良反应发生率、预防药物经济学成本、炎性因子指标[C 反应蛋白（CRP）、白细胞计数（WBC）]水平。结果 观察组术后感染发生率（6.45%）低于对照组（19.35%）（P＜0.05）；与对照组比较，观察组术后体温恢复时间、白细胞计数恢复时间及住院时间更短（P＜0.05），而观察组肛门排气时间与对照组比较，差异无统计学意义（P＞0.05）；与对照组比较，观察组不良反应发生率较低，但差异无统计学意义（P＞0.05）；与对照组比较，观察组预防药物经济学成本更低（P＜0.05）；与术前比较，两组术后CRP、WBC水平更高，但与对照组比较，观察组术后CRP、WBC水平更低（P＜0.05）。结论 头孢曲松钠可有效降低腹腔镜胆囊切除术患者术后感染发生率，缩短临床恢复时间，降低炎性因子水平，且用药成本低，安全性较高。
Abstract:
Objective To study the preventive effect of ceftriaxone sodium on postoperative infection in patients undergoing laparoscopic cholecystectomy. Methods Using the random number table method, a total of 62 patients undergoing laparoscopic cholecystectomy in our hospital from February 2020 to February 2023 were divided into control group and observation group, with 31 patients in each group. Patients in the control group were treated with cefuroxime sodium for injection, and patients in the observation group were treated with ceftriaxone sodium for injection. The incidence of postoperative infection, clinical recovery indicators (body temperature recovery, white blood cell count recovery, anal exhaust and hospitalization time), incidence of adverse reactions, cost of preventive pharmacoeconomics, inflammatory factor indicators [C-reactive protein (CRP), white blood cell count (WBC)] levels were compared between the two groups. Results The incidence of postoperative infection in the observation group (6.45%) was lower than that in the control group (19.35%) (P<0.05). Compared with the control group, the postoperative body temperature recovery time, white blood cell count recovery time and hospitalization time of the observation group were shorter (P<0.05), but there was no significant difference in anal exhaust time between the observation group and control (P>0.05). Compared with the control group, the incidence of adverse reactions in the observation group was lower, but the difference was not statistically significant (P>0.05). Compared with the control group, the cost of preventive pharmacoeconomics in the observation group was lower (P<0.05). Compared with before operation, the levels of CRP and WBC in the two groups were higher after operation, but compared with the control group, the levels of CRP and WBC in the observation group were lower after operation (P<0.05). Conclusion Ceftriaxone sodium can effectively reduce the incidence of postoperative infection in patients undergoing laparoscopic cholecystectomy, shorten the clinical recovery time, reduce the level of inflammatory factors, and has low medication cost and high safety.

参考文献/References:

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更新日期/Last Update: 1900-01-01