[1]徐仁沙,杨广民.血清KL-6表达对社区获得性肺炎严重程度的诊断价值[J].医学信息,2025,38(04):124-127.[doi:10.3969/j.issn.1006-1959.2025.04.022]
　XU Rensha,YANG Guangmin.Diagnostic Value of Serum KL-6 Expression in the Severity of Community-acquired Pneumonia[J].Journal of Medical Information,2025,38(04):124-127.[doi:10.3969/j.issn.1006-1959.2025.04.022]
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血清KL-6表达对社区获得性肺炎严重程度的诊断价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
38卷
期数:
2025年04期
页码:
124-127
栏目:
论著
出版日期:
2025-02-15

文章信息/Info

Title:
Diagnostic Value of Serum KL-6 Expression in the Severity of Community-acquired Pneumonia
文章编号:
1006-1959（2025）04-0124-04
作者:
徐仁沙1; 杨广民2
1.长春中医药大学临床医学院，吉林 长春 130000；2.吉林省人民医院检验科，吉林 长春 130000
Author(s):
XU Rensha1; YANG Guangmin2
1.School of Clinical Medicine, Changchun University of Traditional Chinese Medicine, Changchun 130000, Jilin, China; 2.Department of Laboratory, Jilin Provincial People′s Hospital, Changchun 130000, Jilin, China
关键词:
血清KL-6; 社区获得性肺炎; 重症
Keywords:
Serum KL-6;  Community-acquired pneumonia;  Severe disease
分类号:
R563.1
DOI:
10.3969/j.issn.1006-1959.2025.04.022
文献标志码:
A
摘要:
目的 探究血清涎液化糖链抗原（KL-6）表达对社区获得性肺炎（CAP）严重程度的预测价值。方法 选取2022年3月-4月收住在吉林省人民医院的CAP成人患者128例（重症组18例，非重症组110例）。另选性别、年龄与之相匹配的健康体检者128例（健康对照组）。检测并对比三组血清KL-6水平，分析血清KL-6表达与CAP严重程度的关系，采用受试者工作特征曲线（ROC 曲线）分析血清KL-6水平对重症CAP的预测价值观察血清KL-6水平作为鉴别重症与非重症的敏感性及特异性。结果 重症组合并肝脏疾病、肾脏疾病、电解质紊乱、脑梗的合并率高于非重症组，差异有统计学意义（P＜0.05），而两者合并高血压、糖尿病、心脏病占比比较，差异无统计学意义（P＞0.05）。重症组血清KL-6水平高于非重症组、健康对照组，非重症患者组血清KL-6水平高于健康对照组（P＜0.05）。ROC分析可知，曲线下面积（AUC）为92.20%，95%CI（0.920，0.924），P=0.000，最佳临界值为439 U/ml，敏感性为99.00%，特异性为82.10%。结论 血清KL-6水平与CAP严重程度有关，对早期预测重症CAP具有重要的参考价值，值得临床应用。
Abstract:
Objective To explore the predictive value of Krebs von den Lungen 6 (KL-6) expression for the severity of community-acquired pneumonia (CAP). Methods A total of 128 adult patients with CAP (18 patients in the severe group and 110 patients in the non-severe group) admitted to Jilin Provincial People’s Hospital from March to April 2022 were selected. Another 128 healthy subjects (healthy control group) with matching gender and age were selected. The serum KL-6 levels of the three groups were detected and compared, and the relationship between serum KL-6 expression and the severity of CAP was analyzed. The receiver operating characteristic curve (ROC curve) was used to analyze the predictive value of serum KL-6 level for severe CAP. The sensitivity and specificity of serum KL-6 level as a differential diagnosis of severe and non-severe. Results The combined rate of severe group with liver disease, kidney disease, electrolyte disorder and cerebral infarction was higher than that of non-severe group, and the difference was statistically significant (P<0.05), while there was no significant difference in the proportion of hypertension, diabetes, heart disease between the two groups (P>0.05). The serum KL-6 level in severe group was higher than that in non-severe group and healthy control group, and the serum KL-6 level in non-severe group was higher than that in healthy control group (P<0.05). ROC analysis showed that the area under the curve (AUC) was 92.20%, and the 95%CI was (0.920, 0.924), P=0.000. The optimal critical value was 439 U/ml, the sensitivity was 99.00%, and the specificity was 82.10%. Conclusion Serum KL-6 level is related to the severity of CAP, which has important reference value for early prediction of severe CAP and is worthy of clinical application.

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更新日期/Last Update: 1900-01-01