[1]江立基,李先明.碳酸酐酶Ⅸ在肿瘤中的研究进展[J].医学信息,2018,31(03):7-9.[doi:10.3969/j.issn.1006-1959.2018.03.003]
 JIANG Li-ji,LI Xian-ming.Research Progress of Carbonic Anhydrase IX in Cancer[J].Medical Information,2018,31(03):7-9.[doi:10.3969/j.issn.1006-1959.2018.03.003]
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碳酸酐酶Ⅸ在肿瘤中的研究进展()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年03期
页码:
7-9
栏目:
出版日期:
2018-02-01

文章信息/Info

Title:
Research Progress of Carbonic Anhydrase IX in Cancer
文章编号:
1006-1959(2018)03-0007-03
作者:
江立基李先明
暨南大学第二临床学院深圳市人民医院肿瘤放疗科,广东 深圳 518020
Author(s):
JIANG Li-jiLI Xian-ming
Department of Tumor Radiotherapy,Shenzhen People’s Hospital,Second Clinical College of Jinan University,Shenzhen 518020,Guangdong,China
关键词:
碳酸酐酶Ⅸ肿瘤乏氧诱导因子-1
Keywords:
Carbonic anhydrase IXTumorHypoxia inducible factor -1
分类号:
R730
DOI:
10.3969/j.issn.1006-1959.2018.03.003
文献标志码:
A
摘要:
碳酸酐酶Ⅸ属于跨膜蛋白酶,分布于细胞膜和细胞核,CAⅨ基因是乏氧诱导因子-1(HIF-1)的下游靶基因,乏氧条件能诱导其表达并且与肿瘤的发生发展、治疗敏感性及患者预后相关。近年来CAⅨ已成为一个肿瘤潜在的靶向治疗热点,本文就CAⅨ在肿瘤中的研究进展作一综述。
Abstract:
Carbonic anhydrase Ⅸ is a transmembrane protease located in the cell membrane and nucleus.CAⅨ gene is a downstream target of hypoxia-inducible factor-1(HIF-1),under hypoxic conditions can induce its expression and with the development of tumors, the treatment of sensitivity and patient prognosis.In recent years,CAⅨ has become a potential target of cancer therapy.This article reviews the research progress of CAⅨ in cancer.

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更新日期/Last Update: 2018-02-01