[1]张建强,蒋 鹏,顾新伟,等.公民逝世后器官捐献合并AKI供体肾移植的疗效观察[J].医学信息,2019,32(12):96-98,101.[doi:10.3969/j.issn.1006-1959.2019.12.029]
　ZHANG Jian-qiang,JIANG Peng,GU Xin-wei,et al.Therapeutic Effect of Organ Donation Combined with AKI Donor Kidney Transplantation after the Death of Citizens[J].Journal of Medical Information,2019,32(12):96-98,101.[doi:10.3969/j.issn.1006-1959.2019.12.029]
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公民逝世后器官捐献合并AKI供体肾移植的疗效观察()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年12期
页码:
96-98,101
栏目:
临床研究
出版日期:
2019-06-15

文章信息/Info

Title:
Therapeutic Effect of Organ Donation Combined with AKI Donor Kidney Transplantation after the Death of Citizens
文章编号:
1006-1959（2019）12-0096-04
作者:
张建强; 蒋 鹏; 顾新伟; 武 桢; 高宏君
广西中医药大学附属瑞康医院泌尿外科，广西 南宁 531000
Author(s):
ZHANG Jian-qiang; JIANG Peng; GU Xin-wei; WU Zhen; GAO Hong-jun
Department of Urology,Ruikang Hospital,Guangxi University of Traditional Chinese Medicine,Nanning 531000,Guangxi,China
关键词:
急性肾损伤; 肾移植; 公民逝世后器官捐献
Keywords:
key words：Acute kidney injury; Kidney transplantation; Organ donation after citizen's death
分类号:
R617
DOI:
10.3969/j.issn.1006-1959.2019.12.029
文献标志码:
A
摘要:
目的 探讨公民逝世后器官捐献（DCD）合并急性肾损伤（AKI）供体肾移植的临床疗效。方法 回顾性分析2015年1月~2017年11月我院纳入的DCD 42例，其中合并AKI供体13例，非AKI供体29例，比较两组供者、受者一般资料、两组受者术后指标及并发症发生率。结果 本研究共13例AKI供体，其中标准供体7例，扩大标准供体6例；对照组29例非AKI供体，标准供体28例，扩大标准供体1例。两组供体年龄、性别、死亡原因、初始Scr及热缺血时间比较，差异无统计学意义（P＞0.05）；AKI组EDC供体占比、获取前Scr水平均高于对照组，差异有统计学意义（P＜0.05）。AKI组中13例AKI供体行肾移植24例，对照组29例非AKI供体行肾移植56例。两组受者年龄、性别、体重指数、人类白细胞抗原错配数、群体反应性抗体＞10%、冷缺血时间、灌注流量、灌注阻力指数比较，差异无统计学意义（P＞0.05）；AKI组肾脏机械灌注占比高与对照组，差异有统计学意义（P＜0.05）。AKI组受者DGF发生率、DGF天数、住院时间，术后1周、1月Scr水平均高于对照组，差异有统计学意义（P＜0.05）；两组术后1年Scr水平、术后1年肾小球滤过率、术后1年移植肾存活率及术后1年患者存活率比较，差异无统计学意义（P＞0.05）。AKI组并发症总发生率为37.50%，高于对照组的12.50%，差异有统计学意义（P＜0.05）。结论 DCD合并AKI的供体肾移植受者能获得较好的疗效，可作为扩大供体池的一种选择。
Abstract:
Abstract：Objective To investigate the clinical efficacy of organ donation (DCD) combined with acute kidney injury (AKI) donor kidney transplantation after the death of citizens. Methods A retrospective analysis of 42 cases of DCD included in our hospital from January 2015 to November 2017, including 13 cases of AKI donors and 29 cases of non-AKI donors, comparing the donors and recipients of the two groups, the two groups were Postoperative indicators and complication rates. Results A total of 13 AKI donors were included in the study, including 7 standard donors and 6 expanded standard donors; 29 non-AKI donors in the control group, 28 standard donors, and 1 expanded standard donor. There were no significant differences in donor age, gender, cause of death, initial Scr and warm ischemia time between the two groups (P>0.05). The proportion of EDC donors in the AKI group and the Scr level before the acquisition were higher than the control group,the difference was statistically significant (P<0.05). In AKI group, 13 AKI donors underwent renal transplantation in 24 cases.56 renal transplantation was performed in 29 cases of non-AKI donors in the control group. There were no significant differences in age, gender, body mass index, human leukocyte antigen mismatch, population reactive antibody >10%, cold ischemia time, perfusion flow, and perfusion resistance index between the two groups (P>0.05). The renal mechanical perfusion ratio in the AKI group was higher than that in the control group,the difference was statistically significant (P<0.05). The incidence of DGF, the number of days of DGF, the length of hospital stay in AKI group, the level of Scr in 1 week and 1 month after operation were higher than those in the control group, the difference was statistically significant (P<0.05). The Scr level was 1 year after operation. There was no significant difference in the glomerular filtration rate, the survival rate of transplanted kidneys and the survival rate of patients after 1 year after operation in the first year (P>0.05). The total incidence of complications in the AKI group was 37.50%, which was higher than that in the control group 12.50%,the difference was statistically significant (P<0.05). Conclusion DCD combined with AKI donor kidney transplant recipients can obtain better curative effect and can be used as an option to expand the donor pool.

参考文献/References:

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更新日期/Last Update: 2019-06-15