[1]李 静.氯沙坦联合丹参酮注射液治疗高血压肾损害的疗效[J].医学信息,2019,32(16):138-140.[doi:10.3969/j.issn.1006-1959.2019.16.046]
　LI Jing.Efficacy of Losartan Combined with Tanshinone Injection in the Treatment of Hypertensive Renal Damage[J].Journal of Medical Information,2019,32(16):138-140.[doi:10.3969/j.issn.1006-1959.2019.16.046]
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氯沙坦联合丹参酮注射液治疗高血压肾损害的疗效()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年16期
页码:
138-140
栏目:
药物与临床
出版日期:
2019-08-15

文章信息/Info

Title:
Efficacy of Losartan Combined with Tanshinone Injection in the Treatment of Hypertensive Renal Damage
文章编号:
1006-1959（2019）16-0138-03
作者:
李 静
天津市东丽区中医医院内科，天津 300300
Author(s):
LI Jing
Department of Internal Medicine,Traditional Chinese Medicine Hospital of Dongli District, Tianjin 300300,China
关键词:
高血压; 肾损害; 氯沙坦; 丹参酮
Keywords:
Key words：Hypertension; Kidney damage; Losartan; Tanshinone
分类号:
R544.1
DOI:
10.3969/j.issn.1006-1959.2019.16.046
文献标志码:
A
摘要:
目的 探讨氯沙坦联合丹参酮注射液治疗高血压肾损害的临床疗效。方法 选取2018年1月~12月我院收治高血压肾损害患者60例作为研究对象，采用随机数字表法分为观察组和对照组，每组30例。对照组给予氯沙坦治疗，观察组在对照组基础上联合丹参酮注射液治疗，比较两组治疗前后血压变化情况、血肌酐变化情况、β微球蛋白以及24h尿蛋白情况进行对比。结果治疗前两组收缩压、舒张压、血肌酐比较，差异无统计学意义（P＞0.05）；治疗后，观察组收缩压、舒张压、血肌酐水平均低于对照组[（130.67±5.49）mmHg vs（138.16±7.13）mmHg]、[（81.19±2.12）mmHg vs（87.49±2.84）mmHg]、[（137.15±6.49）μmol/L vs（158.67±8.61）μmol/L]，差异有统计学意义（P＜0.05）。治疗前两组β微球蛋白、24h尿蛋白比较，差异无统计学意义（P＞0.05）；治疗后，观察组β微球蛋白、24h尿蛋白均低于对照组[（0.54±0.42）μg/ml vs（0.86±0.69）μg/ml]、[（0.52±0.29）g/24h vs（0.89±0.35）g/24h]，差异有统计学意义（P＜0.05）。结论 氯沙坦联合丹参酮注射液可有效降低患者血压、血肌酐水平、β微球蛋白、24h尿蛋白，优于单一氯沙坦治疗。
Abstract:
Abstract：Objective To investigate the clinical efficacy of losartan combined with tanshinone injection in the treatment of hypertensive renal damage. Methods A total of 60 patients with hypertension and renal damage in our hospital from January to December 2018 were enrolled. The patients were divided into observation group and control group by random number table, 30 cases in each group. The control group was treated with losartan. The observation group was treated with tanshinone injection on the basis of the control group. The blood pressure changes, serum creatinine changes, β-microglobulin and 24h urine protein were compared before and after treatment.Results There was no significant difference in systolic blood pressure, diastolic blood pressure and serum creatinine between the two groups before treatment (P>0.05). After treatment, the systolic blood pressure, diastolic blood pressure and serum creatinine level in the observation group were lower than those in the control group [(130.67±5.49) mmHg vs (138.16±7.13) mmHg], [(81.19±2.12) mmHg vs (87.49±2.84) mmHg], [(137.15±6.49) μmol/L vs (158.67±8.61) μmol/L], the difference was statistically significant(P<0.05). Comparison of β-microglobulin and 24h urine protein between the two groups before treatment, the difference was not statistically significant (P>0.05). After treatment, the β-microglobulin and 24h urine protein in the observation group were lower than the control group [(0.54±0.42)μg/ml vs(0.86±0.69)μg/ml], [(0.52±0.29) g/24h vs(0.89±0.35) g/24h], the difference was statistically significant (P<0.05).Conclusion Losartan combined with tanshinone injection can effectively reduce blood pressure, serum creatinine level, β-microglobulin and 24h urine protein, which is better than single losartan treatment.

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更新日期/Last Update: 2019-08-15