[1]裴金仙,陈天狮,任巧晶,等.IL-23在慢性乙型肝炎免疫调节中的作用研究[J].医学信息,2019,32(08):129-130.[doi:10.3969/j.issn.1006-1959.2019.08.037]
　PEI Jin-xian,CHEN Tian-shi,REN Qiao-jing,et al.The Role of IL-23 in the Immune Regulation of Chronic Hepatitis B[J].Journal of Medical Information,2019,32(08):129-130.[doi:10.3969/j.issn.1006-1959.2019.08.037]
点击复制

IL-23在慢性乙型肝炎免疫调节中的作用研究()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年08期
页码:
129-130
栏目:
临床研究
出版日期:
2019-04-15

文章信息/Info

Title:
The Role of IL-23 in the Immune Regulation of Chronic Hepatitis B
文章编号:
1006-1959（2019）08-0129-02
作者:
裴金仙; 陈天狮; 任巧晶; 王晋江; 罗瑞丽
（山西省人民医院感染性疾病科，山西 太原 030012）
Author(s):
PEI Jin-xian; CHEN Tian-shi; REN Qiao-jing; WANG Jin-jiang; LUO Rui-li
(Department of Infectious Dieseases,Shanxi Provincial People's Hospital,Taiyuan 030012,Shanxi, China)
关键词:
IL-23; 乙型肝炎; Th17
Keywords:
Interleukin-23; Chronic hepatitis B; Th17
分类号:
R512.62
DOI:
10.3969/j.issn.1006-1959.2019.08.037
文献标志码:
A
摘要:
目的 探讨IL-23在慢性乙型肝炎免疫调节中的作用。方法 选取我院收治的32例HBeAg阳性慢性乙型肝炎患者为研究对象，根据ALT水平分为ALT≥120 IU/ml患者16例，ALT＜120 IU/ml患者16例，另外选择我院健康体检中心20例体检者作为健康对照组，采用酶联免疫分析法（ELISA）检测血清IL-23水平，采用流式细胞仪检测Th17细胞百分率。结果 与健康对照组相比，HBeAg阳性慢性乙型肝炎患者血清IL-23表达及外周血Th17细胞百分率均升高，差异有统计学意义（P＜0.05）； ALT≥120 IU/ml患者血清IL-23浓度（394.81±101.84）pg/ml高于ALT＜120IU/ml的（283.69±85.65）pg/ml，ALT≥120 IU/ml患者Th17细胞百分率（3.25±0.70）%高于ALT＜120IU/ml的（2.68±0.61）%，差异均有统计学意义（P＜0.05）；慢性乙型肝炎患者外周血Th17细胞百分率、血清IL-23浓度与ALT程度呈正相关（P均＜0.05）；Th17细胞百分率与血清IL-23浓度呈正相关（P＜0.05）。结论 IL-23可能通过影响Th17细胞的免疫调节参与慢性乙型肝炎患者炎症，为临床提供了新的靶标。
Abstract:
Objective To investigate the role of IL-23 in the immunomodulation of chronic hepatitis B.Methods 32 patients with HBeAg-positive chronic hepatitis B admitted to our hospital were enrolled. According to the ALT level, 16 patients with ALT≥120 IU/ml and 16 patients with ALT<120 IU/ml were selected. 20 patients in the center were used as healthy controls. Serum IL-23 levels were measured by enzyme-linked immunosorbent assay (ELISA), and the percentage of Th17 cells was detected by flow cytometry.Results Compared with the healthy control group, the expression of serum IL-23 and the percentage of peripheral blood Th17 cells in HBeAg-positive chronic hepatitis B patients were significantly increased (P<0.05). Serum IL in patients with ALT≥120 IU/ml -23 concentration (394.81±101.84) pg/ml was higher than ALT<120 IU/ml (283.69±85.65) pg/ml, ALT≥120IU/ml patients with Th17 cell percentage (3.25±0.70)% higher than ALT<120 IU/ml (2.68±0.61)%, the difference was statistically significant (P<0.05); the percentage of Th17 cells and serum IL-23 in peripheral blood of patients with chronic hepatitis B were positively correlated with the degree of ALT (P<0.05); Th17 cells The percentage was positively correlated with serum IL-23 concentration (P<0.05). Conclusion IL-23 may participate in the inflammation of patients with chronic hepatitis B by affecting the immune regulation of Th17 cells, providing a new target for clinical.

参考文献/References:

[1]Weaver CT,Harrington LE,Mangan PR,et al.Th17:an effector CD4 T cell lineage with regulatory T cell ties[J].Immunity,2006,24(6):677-688. [2]Isogawa M,Tanaka Y.Immunobiology of hepatitis B virus infection[J].Hepatol Ras,2015,45(2):179-189. [3]Liu Y,Li L,Liu J,et al.Activated hepatic stellate cells directly induce pathogenic Th17 cells in chronic hepatitis B virus infection[J].Exp Cell Res,2017,359(1):129-137. [4]Yang C,Cui F,Chen LM,et al.Correlation between Th17 and nTreg cell frequencies and the stages of progression in chronic hepatitis B[J].Mol Med Rep,2016,13(1):853-859. [5]Paquissi FC.Immunity and fibrogenesis: the role of Th17/IL-17 axis in HBV and HCV-induced chronic hepatitis and progression to cirrhosis[J].Front Immuno,2017(8):1195. [6]Sun L,He C,Nair L,et al.Interleukin 12(IL-12)family cytokines: role in immune pathogenesis and treatment of CNS autoimmune disease[J].Cytokine,2015,75(2):249-255. [7]Gaffen SL,Jain R,Garg AV,et al.The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing[J].Nat Rev Immunol,2014,14(9):585-600.

相似文献/References:

[1]李安乐,戴 夫,彭 琼.中性粒细胞与淋巴细胞比值、红细胞体积分布宽度与乙型肝炎及乙型肝炎肝硬化的关系研究[J].医学信息,2019,32(03):69.[doi:10.3969/j.issn.1006-1959.2019.03.022]
　LI An-le,DAI Fu,PENG Qiong.Relationship between Neutrophil-lymphocyte Ratio,Red Blood Cell Volume Distribution Width and Hepatitis B and Hepatitis B Cirrhosis[J].Journal of Medical Information,2019,32(08):69.[doi:10.3969/j.issn.1006-1959.2019.03.022]
[2]王媛媛.乙型肝炎患者血清免疫球蛋白检测的意义[J].医学信息,2018,31(18):155.[doi:10.3969/j.issn.1006-1959.2018.18.050]
　WANG Yuan-yuan.Significance of Detection of Serum Immunoglobulin in Patients with Hepatitis B[J].Journal of Medical Information,2018,31(08):155.[doi:10.3969/j.issn.1006-1959.2018.18.050]
[3]桂志兵,汪文生.红细胞分布宽度与血小板计数比值在乙型肝炎肝硬化患者病情评估中的作用[J].医学信息,2018,31(20):65.[doi:10.3969/j.issn.1006-1959.2018.20.019]
　GUI Zhi-bing,WANG Wen-sheng.The Role of Red Blood Cell Distribution Width and Platelet Ratio in the Evaluation of Patients with Hepatitis B Cirrhosis[J].Journal of Medical Information,2018,31(08):65.[doi:10.3969/j.issn.1006-1959.2018.20.019]
[4]洪 亮,陶 静,张 静,等.上海市男性同性恋HIV感染者中乙型肝炎、丙型肝炎病毒的合并感染情况横断面研究[J].医学信息,2019,32(06):145.[doi:10.3969/j.issn.1006-1959.2019.06.046]
　HONG Liang,TAO Jing,ZHANG Jing,et al.Cross-sectional Study on the Co-infection of Hepatitis B and Hepatitis C Virus among HIV-infected People in Shanghai[J].Journal of Medical Information,2019,32(08):145.[doi:10.3969/j.issn.1006-1959.2019.06.046]
[5]方志军.实时荧光PCR检测乙肝病毒DNA的效果评价[J].医学信息,2019,32(22):175.[doi:10.3969/j.issn.1006-1959.2019.22.062]
　FANG Zhi-jun.Evaluation of the Effect of Real-time Fluorescent PCR on Detection of Hepatitis B Virus DNA[J].Journal of Medical Information,2019,32(08):175.[doi:10.3969/j.issn.1006-1959.2019.22.062]
[6]肖岑昕,黄恒青.肠道微生物群与慢性病毒性肝炎的关系[J].医学信息,2021,34(21):39.[doi:10.3969/j.issn.1006-1959.2021.21.009]
　XIAO Cen-xin,HUANG Heng-qing.Relationship Between Intestinal Microflora and Chronic Viral Hepatitis[J].Journal of Medical Information,2021,34(08):39.[doi:10.3969/j.issn.1006-1959.2021.21.009]
[7]李毓龙,刘 琴,黄倩倩.免疫球蛋白检测在乙型肝炎患者的应用价值[J].医学信息,2020,33(13):173.[doi:10.3969/j.issn.1006-1959.2020.13.055]
　LI Yu-long,LIU Qin,HUANG Qian-qian.Application Value of Immunoglobulin Detection in Patients with Hepatitis B[J].Journal of Medical Information,2020,33(08):173.[doi:10.3969/j.issn.1006-1959.2020.13.055]
[8]王明杰,秦玉杰.聚乙二醇干扰素α序贯联合核苷类药物治疗高病毒载量e抗原阳性乙型肝炎的疗效[J].医学信息,2021,34(19):107.[doi:10.3969/j.issn.1006-1959.2021.19.027]
　WANG Ming-jie,QIN Yu-jie.Efficacy of Peginterferon α Sequential Combined with Nucleoside Drugs in theTreatment of High Viral Load e Antigen Positive Hepatitis B[J].Journal of Medical Information,2021,34(08):107.[doi:10.3969/j.issn.1006-1959.2021.19.027]
[9]孙燕飞.替诺福韦酯治疗乙型肝炎的效果及对复发率的影响[J].医学信息,2024,37(08):121.[doi:10.3969/j.issn.1006-1959.2024.08.024]
　SUN Yan-fei.Effect of Tenofovir Disoproxil in the Treatment of Hepatitis B and its Effect on Recurrence Rate[J].Journal of Medical Information,2024,37(08):121.[doi:10.3969/j.issn.1006-1959.2024.08.024]

更新日期/Last Update: 2019-04-15