[1]余世纪,谢勇丽,苏晓清.血清VDBP、IL-8、sTWEAK与尿VDBP早期诊断糖尿病肾病的价值[J].医学信息,2019,32(09):38-40.[doi:10.3969/j.issn.1006-1959.2019.09.013]
 YU Shi-ji,XIE Yong-li,SU Xiao-qing.The Value of Serum VDBP,IL-8,sTWEAK and Urine VDBP in Early Diagnosis of Diabetic Nephropathy[J].Journal of Medical Information,2019,32(09):38-40.[doi:10.3969/j.issn.1006-1959.2019.09.013]
点击复制

血清VDBP、IL-8、sTWEAK与尿VDBP早期诊断糖尿病肾病的价值()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年09期
页码:
38-40
栏目:
综述
出版日期:
2019-05-01

文章信息/Info

Title:
The Value of Serum VDBP,IL-8,sTWEAK and Urine VDBP in Early Diagnosis of Diabetic Nephropathy
文章编号:
1006-1959(2019)09-0038-03
作者:
余世纪谢勇丽苏晓清
(赣南医学院附属萍乡医院内分泌科,江西 萍乡 337055)
Author(s):
YU Shi-jiXIE Yong-liSU Xiao-qing
(Department of Endocrinology,Pingxiang Hospital Affiliated to Gannan Medical College, Pingxiang 337055,Jiangxi,China)
关键词:
糖尿病肾病早期诊断生物标志物
Keywords:
Diabetic nephropathyEarly diagnosisBiomarkers
分类号:
R587.2;R692
DOI:
10.3969/j.issn.1006-1959.2019.09.013
文献标志码:
A
摘要:
糖尿病肾病(DN)是糖尿病最常见、最严重的并发症之一。确切发病机理较复杂,目前尚未阐明。传统的DN诊断标记物为:血清尿素氮、肌酐、尿蛋白、肾小球滤过率等,目前临床中DN患者多数因未及时干预血糖波动或治疗不当可致终末期肾病,导致肾脏病理损害不可逆,并大幅提高医疗费用,故对于早期诊断DN挑战很大。目前研究发现存在相关生物标记物:血清VDBP、IL-8、sTWEAK与尿VDBP皆有可能成为DN早期诊断的可靠检验指标。本文就上述生物标志物早期诊断DN进展做一综述。
Abstract:
Diabetic nephropathy (DN) is one of the most common and serious complications of diabetes. The exact pathogenesis is more complicated and has not yet been elucidated. The traditional DN diagnostic markers are: serum urea nitrogen, creatinine, urinary protein, glomerular filtration rate, etc. At present, most of the DN patients in the clinic are not affected by blood glucose fluctuations or improper treatment can cause end-stage renal disease, leading to renal pathological damage. It is irreversible and greatly increases medical expenses, so it is very challenging for early diagnosis of DN. At present, it is found that there are related biomarkers: serum VDBP, IL-8, sTWEAK and urinary VDBP may be reliable indicators for early diagnosis of DN. This article reviews the progress of early diagnosis of DN in biomarkers.

参考文献/References:

[1]Campion CG,Sanchez-Ferras O,Batchu SN.Potential role of serum and urinary biomarkers in diagnosis and prognosis of diabetic nephropathy[J].Canadian Journal of Kidney Health and Disease,2017(4):205435811770537.
[2]Yaribeygi H,Butler AE,Barreto GE,et al.Antioxidative potential of antidiabetic agents:A possible protective mechanism against vascular complications in diabetic patients[J].J Cell Physiol,2019,234(3):2436-2446.
[3]Yaribeygi H,Atkin SL,Sahebkar A.A review of the molecular mechanisms of hyperglycemia-induced free radical generation leading to oxidative stress[J].J Cell Physiol,2019,234(2):1300-1312.
[4]Huang GM,Huang KY,Lee TY,et al.An interpretable rule-based diagnostic classification of diabetic nephropathy among type 2 diabetes patients[J].BMC Bioinformatics,2015,16(Suppl 1):S5.
[5]Pfister F,Pfister E,Daniel C,et al.Histopathology of diabetic nephropathy[J].Semin Nephrol,2007,27(2):195-207.
[6]Varghese SA,Powell TB,Budisavljevic MN,et al.Urine biomarkers predict the cause of glomerular disease[J].J Am Soc Nephrol,2007,18(3):913-922.
[7]Chun RF,Peercy BE,Adams JS,et al.Vitamin D binding protein and monocyte response to 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D: analysis by mathematical modeling[J].PLoS One, 2012,7(1):e30773.
[8]Christakos S,Ajibade DV,Dhawan P,et al.Vitamin D:Metabolism[J].Endocrinology & Metabolism Clinics of North America,2010,39(2):243-253.
[9]Mahadevappa R,Nielsen R,Christensen EI,et al.Megalin in acute kidney injury: foe and friend[J]. American Journal of Physiology Renal Physiology,2014,306(2):147-154.
[10]Mirkovic K,Doorenbos CR,Dam WA,et al. Urinary Vitamin D Binding Protein: A Potential Novel Marker of Renal Interstitial Inflammation and Fibrosis[J].PLoS One,2013,8(2):e55887.
[11]Thrailkill KM,Jo CH,Cockrell GE,et al.Enhanced excretion of vitamin D binding protein in type 1 diabetes: a role in vitamin D deficiency?[J].Journal of Clinical Endocrinology & Metabolism, 2011,96(1):142-149.
[12]Tian XQ,Zhao LM,Ge JP,et al.Elevated urinary level of vitamin D-binding protein as a novel biomarker for diabetic nephropathy[J].Experimental & Therapeutic Medicine,2014,7(2):411-416.
[13]Shoukry A,Bdeer Sel-A,El-Sokkary RH.Urinary monocyte chemoattractant protein-1 and vitamin D-binding protein as biomarkers for early detection of diabetic nephropathy in type 2 diabetes mellitus[J]. Molecular & Cellular Biochemistry,2015,408(1-2):25-35.
[14]Kalousova M,Dusilovasulkova S,Zakiyanov O,et al.Vitamin D Binding Protein Is Not Involved in Vitamin D Deficiency in Patients with Chronic Kidney Disease[J].Biomed Res Int,2015, 2015(3):492365.
[15]Lowe G,Woodward M,Hillis G,et al.Circulating inflammatory markers and the risk of vascular complications and mortality in people with type 2 diabetes and cardiovascular disease or risk factors: the ADVANCE Study[J].Diabetes,2014,63(3):1115-1123.
[16]María-Castro A,Concha MDL,Pantoja-Meléndez CA.Low-grade inflammation and its relation to obesity and chronic degenerative diseases[J].Revista Médica Del Hospital General De México,2016,80(2):101-105.
[17]Giacco Ferdinando,Brownlee Michael.Oxidative stress and diabetic complications[J]. Circulation Research,2010,107(9):1058-1070.
[18]Hidalgo MA,Carretta MD,Teuber SE,et al.fMLP-Induced IL-8 Release Is Dependent on NADPH Oxidase in Human Neutrophils[J].J Immunol Res,2015,2015(30):120348.
[19] Perlman AS,Chevalier JM,Wilkinson P,et al.Serum Inflammatory and Immune Mediators Are Elevated in Early Stage Diabetic Nephropathy[J].Ann Clin Lab Sci 2015,45(3):256-263.
[20]Liu SY,Chen J,Li YF.Clinical significance of serum interleukin-8 and soluble tumor necrosis factor-like weak inducer of apoptosis levels in patients with diabetic nephropathy[J].J Diabetes Investig,2018,9(5):1182-1188.
[21]Brown SA,Ghosh A,Winkles JA.Full-length,membrane-anchored TWEAK can function as a juxtacrine signaling molecule and activate the NF-kappaB pathway[J].Journal of Biological Chemistry,2010,285(23):17432-17441.
[22]Valdivielso JM,Coll B,Martín-Ventura JL,et al.Soluble TWEAK is associated with atherosclerotic burden in patients with chronic kidney disease[J].Journal of Nephrology,2013,26(6):1105-1113.
[23]Díaz-López A,Chacón MR,Bulló M,et al.Serum sTWEAK concentrations and risk of developing type 2 diabetes in a high cardiovascular risk population:a nested case-control study[J].Journal of Clinical Endocrinology & Metabolism,2013,98(8):3482-3490.

相似文献/References:

[1]朱津津.Hcy、BNP检测在2型糖尿病肾病早期诊断中的价值分析[J].医学信息,2018,31(03):163.[doi:10.3969/j.issn.1006-1959.2018.03.060]
 ZHU Jin-jin.The Value of Hcy and BNP in the Early Diagnosis of Type 2 Diabetic Nephropathy[J].Journal of Medical Information,2018,31(09):163.[doi:10.3969/j.issn.1006-1959.2018.03.060]
[2]陈淑雯.肾衰宁联合科素亚治疗早期糖尿病肾病的临床观察[J].医学信息,2018,31(05):20.[doi:10.3969/j.issn.1006-1959.2018.05.007]
 CHEN Shu-wen.Clinical Observation on Early Diabetic Nephropathy Treated by Shenshuaining Combined with Kosu[J].Journal of Medical Information,2018,31(09):20.[doi:10.3969/j.issn.1006-1959.2018.05.007]
[3]何丽杰.中西医治疗糖尿病肾病的临床效果分析[J].医学信息,2018,31(10):149.[doi:10.3969/j.issn.1006-1959.2018.10.051]
 HE Li-jie.Clinical Effect Analysis of Diabetic Nephropathy Treated by Chinese and Western Medicine[J].Journal of Medical Information,2018,31(09):149.[doi:10.3969/j.issn.1006-1959.2018.10.051]
[4]覃 艺,邓燕艺,赖昌生,等.554例儿童重症手足口病的临床特征分析[J].医学信息,2018,31(11):115.[doi:10.3969/j.issn.1006-1959.2018.11.036]
 QIN Yi,DENG Yan-yi,LAI Chang-sheng,et al.Analysis of Clinical Features of Severe Hand Foot and Mouth Disease in 554 Children[J].Journal of Medical Information,2018,31(09):115.[doi:10.3969/j.issn.1006-1959.2018.11.036]
[5]贺 伟,高 峰.24 h尿微量白蛋白、血清胱抑素C水平与血清肌酐、尿素水平在2型糖尿病肾病早期诊断的意义[J].医学信息,2018,31(11):151.[doi:10.3969/j.issn.1006-1959.2018.11.049]
 HE Wei,GAO Feng.The Significance of 24 h Urinary Microalbumin,Serum Cystatin C and Serum Creatinine and Urea Levels in the Early Diagnosis of Type 2 Diabetic Nephropathy[J].Journal of Medical Information,2018,31(09):151.[doi:10.3969/j.issn.1006-1959.2018.11.049]
[6]陈学敏,彭 琼.中性粒细胞与淋巴细胞比值联合癌胚抗原对结直肠癌早期诊断的研究[J].医学信息,2019,32(02):75.[doi:10.3969/j.issn.1006-1959.2019.02.022]
 CHEN Xue-min,PENG Qiong.Early Diagnosis of Colorectal Cancer by Neutrophil-lymphocyte Ratio Combined with Carcinoembryonic Antigen[J].Journal of Medical Information,2019,32(09):75.[doi:10.3969/j.issn.1006-1959.2019.02.022]
[7]黄秋菊.胱抑素C及脂蛋白α在早期糖尿病肾病诊断中的价值研究[J].医学信息,2018,31(14):57.[doi:10.3969/j.issn.1006-1959.2018.14.018]
 HUANG Qiu-ju.The Value of Cystatin C and Lipoprotein α in the Diagnosis of Early Diabetic Nephropathy[J].Journal of Medical Information,2018,31(09):57.[doi:10.3969/j.issn.1006-1959.2018.14.018]
[8]陆新虹,温玉洁,胡 欣,等.α-硫辛酸对2型糖尿病肾病患者 血清内脂素的影响研究[J].医学信息,2018,31(14):60.[doi:10.3969/j.issn.1006-1959.2018.14.019]
 LU Xin-hong,WEN Yu-jie,HU Xin,et al.Effect of α-lipoic Acid on Serum Visfatin in Patients with Type 2 Diabetic Nephropathy[J].Journal of Medical Information,2018,31(09):60.[doi:10.3969/j.issn.1006-1959.2018.14.019]
[9]肖学秀.益气活血汤联合西药治疗早期糖尿病肾病的临床观察[J].医学信息,2019,32(02):166.[doi:10.3969/j.issn.1006-1959.2019.02.051]
 XIAO Xue-xiu.Clinical Observation of Yiqi Huoxue Decoction Combined with Western Medicine in Treating Earlyn Diabetic Nephropathy[J].Journal of Medical Information,2019,32(09):166.[doi:10.3969/j.issn.1006-1959.2019.02.051]
[10]郑小鹏,辛 华.糖尿病肾病研究进展[J].医学信息,2018,31(16):26.[doi:10.3969/j.issn.1006-1959.2018.16.008]
 ZHENG Xiao-peng,XIN Hua.Progress in the Study of Diabetic Nephropathy[J].Journal of Medical Information,2018,31(09):26.[doi:10.3969/j.issn.1006-1959.2018.16.008]

更新日期/Last Update: 2019-05-01