[1]韩 晋,陈淑媛,董瑞宾,等.神经生长因子与盐酸氟桂利嗪联合治疗高血压脑出血的疗效[J].医学信息,2019,32(21):81-84.[doi:10.3969/j.issn.1006-1959.2019.21.025]
　HAN Jin,CHEN Shu-yuan,DONG Rui-bin,et al.Effect of Nerve Growth Factor Combined with Flunarizine Hydrochloride on Hypertensive Intracerebral Hemorrhage[J].Journal of Medical Information,2019,32(21):81-84.[doi:10.3969/j.issn.1006-1959.2019.21.025]
点击复制

神经生长因子与盐酸氟桂利嗪联合治疗高血压脑出血的疗效()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年21期
页码:
81-84
栏目:
论著
出版日期:
2019-11-01

文章信息/Info

Title:
Effect of Nerve Growth Factor Combined with Flunarizine Hydrochloride on Hypertensive Intracerebral Hemorrhage
文章编号:
1006-1959（2019）21-0081-04
作者:
韩 晋; 陈淑媛; 董瑞宾; 石艳超
（天津港口医院神经内科，天津 300456）
Author(s):
HAN Jin; CHEN Shu-yuan; DONG Rui-bin; SHI Yan-chao
(Department of Neurology,Tianjin Port Hospital,Tianjin 300456,China)
关键词:
神经生长因子; 盐酸氟桂利嗪; 高血压脑出血; 血流动力学
Keywords:
Nerve growth factor; Flunarizine hydrochloride; Hypertensive intracerebral hemorrhage; Hemodynamics
分类号:
R743.34
DOI:
10.3969/j.issn.1006-1959.2019.21.025
文献标志码:
A
摘要:
目的 探讨神经生长因子与盐酸氟桂利嗪治疗高血压脑出血患者对促进神经功能恢复、脑血流动力学的影响。方法 选取我院2016年1月~2018年2月收治的110例高血压脑出血患者，采用随机数字表法分为联合组和对照组，各55例，对照组给予常规治疗，联合组同时给予神经生长因子与盐酸氟桂利嗪治疗；比较两组治疗前后的神经功能缺损评分（NIHSS）、改良Rank量表（mRS）评分、血肿体积、日常生活活动能力（ADL）量表评分，血清神经元特异性烯醇化酶（NSE）、S100B蛋白、髓鞘碱性蛋白（MBP），大脑中动脉、前动脉及后动脉的平均血流速度。结果 治疗后，联合组NIHSS评分、血肿体积均低于对照组，差异具有统计学意义（P＜0.05）；联合组血清NSE、S100B蛋白、MBP水平均低于对照组，差异具有统计学意义（P＜0.05）；联合组大脑中动脉、前动脉及后动脉的平均血流速度均高于对照组，差异具有统计学意义（P＜0.05）；治疗3个月后，联合组mRS评分低于对照组（P＜0.05），ADL评分则高于对照组（P＜0.05）；联合组不良反应发生率为10.91%，高于对照组的5.45%，但差异无统计学意义（P＞0.05）。结论 神经生长因子联合盐酸氟桂利嗪治疗高血压脑出血，有利于患者血肿的迅速吸收、改善脑组织的供血，达到促进患者神经功能恢复的作用。
Abstract:
Objective To investigate the effects of nerve growth factor and flunarizine hydrochloride on the recovery of neurological function and cerebral hemodynamics in patients with hypertensive intracerebral hemorrhage. Methods A total of 110 patients with hypertensive cerebral hemorrhage admitted to our hospital from January 2016 to February 2018 were randomly divided into the combined group and the control group, 55 cases in each group. The control group received conventional treatment. The combined group was treated with nerve growth factor and flunarizine hydrochloride. The neurological deficit score (NIHSS), modified Rank scale (mRS) score, hematoma volume, and activities of daily living were compared before and after treatment. Capacity (ADL) scale score, serum neuron specific enolase (NSE), S100B protein, myelin basic protein (MBP), mean blood flow velocity of the middle cerebral artery, anterior and posterior arteries.Results After treatment, the NIHSS score and hematoma volume of the combined group were lower than the control group, the difference was statistically significant (P<0.05). The serum NSE, S100B protein and MBP levels in the combined group were lower than the control group, the difference was statistically significant (P<0.05); the mean blood flow velocity of the middle cerebral artery, anterior artery and posterior artery of the combined group was higher than that of the control group, the difference was statistically significant (P<0.05); After 3 months of treatment, the mRS score of the combined group was lower than that of the control group (P<0.05), and the ADL score was higher than that of the control group (P<0.05). The incidence of adverse reactions in the combined group was 10.91%, which was higher than 5.45% of the control group. However, the difference was not statistically significant (P>0.05).Conclusion Nerve growth factor combined with flunarizine hydrochloride is effective in the treatment of hypertensive intracerebral hemorrhage, which is beneficial to the rapid absorption of hematoma and the improvement of blood supply to brain tissue.

参考文献/References:

[1]王育胜,柯以铨,洪映标,等.30~40 ml高血压脑出血锁孔血肿清除术与内科保守疗法的疗效比较[J].中华神经医学杂志,2016,15(6):629-632. [2]左积文,韩岳,陈丽丽,等.神经生长因子联合奥拉西坦治疗高血压脑出血回顾性研究[J].中国医院药学杂志,2017,37(1):65-68. [3]曹治华,周佩洋,洪艳,等.盐酸氟桂利嗪联合神经生长因子治疗脑出血的临床效果分析[J].中国处方药,2016,14(3):65-65,66. [4]全国第四届脑血管病学术会议.各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-380. [5]阳建国,钟兴明.颅内压监测下控制性减压在软通道穿刺引流术治疗长期服用阿司匹林的高血压脑出血中的应用研究[J].中华神经医学杂志,2018,17(5):507-511. [6]王国飞,康眼训,蔡甜甜,等.低T3综合征及GCS评分与高血压脑出血生存率及再出血的关系研究[J].中华神经医学杂志,2018,17(7):699-704. [7]孙奉辉,徐依成,陈新平,等.高血压脑出血血肿周围水肿与动态血压的相关性研究[J].中华老年心脑血管病杂志,2016,18(6):571-573. [8]曹红磊,刘飞皎,曹红岩,等.神经生长因子联合高压氧治疗高血压脑出血术后患者的疗效观察[J].中国现代医生,2016,54(1):105-108. [9]种莉,陈丽,唐鹏,等.脑心通胶囊联合神经生长因子治疗高血压脑出血的疗效及对血清IL-6、MMP-9、S100B水平的影响[J].现代生物医学进展,2017,17(25):4948-4951. [10]华领洋,曹心怡,郑铭哲, 等.钠/钙交换蛋白SLC24A6在实验性颅内出血导致脑损伤过程中的作用及机制研究[J].中国临床神经科学,2017,25(1):8-14. [11]段红利,何晓英,张光伟,等.盐酸氟桂利嗪与鼠神经生长因子治疗脑出血的效果分析[J].解放军医药杂志,2018,30(8):83-86. [12]石莺,彭汉芬.盐酸氟桂利嗪胶囊联合神经生长因子治疗脑出血的临床疗效及其对患者神经功能和日常生活能力的影响[J].临床合理用药杂志,2018,11(15):41-42. [13]段志辉,曹友林.鼠神经生长因子联合依达拉奉用于治疗脑出血的临床效果及对神经功能的影响[J].中国临床医生杂志,2016,44(4):44-47. [14]张文亮,刘叶,张自豪,等.颅内血肿微创术对高血压脑出血患者经颅多普勒血流参数及血清NSE、S－100B的影响[J].现代中西医结合杂志,2016,25(34):3798-3800. [15]Bergman L,Zetterberg H,Kaihola H,et al.Blood-based cerebral biomarkers in preeclampsia: Plasma concentrations of NfL,tau,S100B and NSE during pregnancy in women who later develop preeclampsia-A nested case control study[J].PLoS One,2018,13(5):e0196025. [16]陈苏,高翠红.S100B联合NSE检测对脑出血诊断的ROC曲线分析[J].山西医科大学学报,2018,49(7):856-858.

相似文献/References:

[1]彭莹萍.尼莫地平与盐酸氟桂利嗪治疗老年偏头痛的临床疗效观察[J].医学信息,2018,31(22):150.[doi:10.3969/j.issn.1006-1959.2018.22.044]
　PENG Ying-ping.Clinical Efficacy of Nimodipine and Flunarizine Hydrochloride in the Treatment of Senile Migraine[J].Journal of Medical Information,2018,31(21):150.[doi:10.3969/j.issn.1006-1959.2018.22.044]
[2]邵垭杰,毕小江,孙心悦,等.倍他司汀联合盐酸氟桂利嗪治疗耳鸣的Meta分析[J].医学信息,2021,34(04):119.[doi:10.3969/j.issn.1006-1959.2021.04.031]
　SHAO Ya-jie,BI Xiao-jiang,SUN Xin-yue,et al.Meta Analysis of Betahistine Combined with Flunarizine Hydrochloride in the Treatment of Tinnitus[J].Journal of Medical Information,2021,34(21):119.[doi:10.3969/j.issn.1006-1959.2021.04.031]
[3]孙鹏飞,王华东.前列舒通联合盐酸坦索罗辛治疗慢性前列腺炎的疗效及对血清PSA、NGF、TGF-β的影响[J].医学信息,2023,36(15):144.[doi:10.3969/j.issn.1006-1959.2023.15.030]
　SUN Peng-fei,WANG Hua-dong.Efficacy of Qianlie Shutong Combined with Tamsulosin Hydrochloride in the Treatment of Chronic Prostatitis and its Effect on Serum PSA, NGF and TGF-β[J].Journal of Medical Information,2023,36(21):144.[doi:10.3969/j.issn.1006-1959.2023.15.030]

更新日期/Last Update: 2019-11-01