[1]宋 京,高 山,孙 洋,等.血脂水平与冠状动脉病变狭窄程度的临床分析[J].医学信息,2020,33(03):92-94.[doi:10.3969/j.issn.1006-1959.2020.03.026]
　SONG Jing,GAO Shan,SUN Yang,et al.Correlation Between Blood Lipid Level and Stenosis of Coronary Artery Disease[J].Medical Information,2020,33(03):92-94.[doi:10.3969/j.issn.1006-1959.2020.03.026]
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血脂水平与冠状动脉病变狭窄程度的临床分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年03期
页码:
92-94
栏目:
论著
出版日期:
2020-02-01

文章信息/Info

Title:
Correlation Between Blood Lipid Level and Stenosis of Coronary Artery Disease
文章编号:
1006-1959（2020）03-0092-03
作者:
宋 京; 高 山; 孙 洋; 等
（1.佳木斯大学附属第一医院心内科，黑龙江 佳木斯 154000；2.齐齐哈尔市第一医院心内科，黑龙江 齐齐哈尔 161000）
Author(s):
SONG Jing1; GAO Shan1; SUN Yang1; YAN Xiao-kun2
(1.Department of Cardiology,the First Affiliated Hospital of Jiamusi University,Jiamusi 154000,Heilongjiang,China;2.Department of Cardiology,Qiqihar First Hospital,Qiqihar 161000,Heilongjiang,China)
关键词:
冠心病; 血脂水平; 冠状动脉狭窄
Keywords:
Coronary heart disease; Blood lipid levels; Coronary artery stenosis
分类号:
R541.4
DOI:
10.3969/j.issn.1006-1959.2020.03.026
文献标志码:
A
摘要:
目的 分析冠心病（CHD）患者血脂水平与冠状动脉病变狭窄程度的相关性。方法 选取2018年6月~2019年6月我院收治的以胸闷、胸痛为主诉入院的350例患者作为研究对象，依据冠状动脉造影检查结果，将150例冠状动脉造影正常者设为对照组，将200例确诊为冠心病的患者设为研究组，并依据Gensini积分划分为低危组（80例）、中危组（65例）和高危组（55例）。比较对照组与研究组临床资料及血脂水平，比较低、中和高危组血脂水平，Logistic回归分析研究组血脂水平与冠状动脉病变狭窄程度的相关性。结果 两组性别、年龄、BMI、饮酒史、吸烟史、糖尿病史、高血压史、收缩压、舒张压、TG、Glu、TC、HDL-C比较，差异无统计学意义（P＞0.05）；研究组LDL-C、Lp（a）高于对照组，差异有统计学意义（P＜0.05）。低、中和高危组TG、TC、HDL-C水平比较，差异无统计学意义（P＞0.05）；低、中和高危组LDL-C、Lp（a）水平依次升高，差异有统计学意义（P＜0.05）。Logistic回归分析显示， LDL-C、Lp（a）是冠状动脉病变狭窄的危险因素；TC、HDL-C是冠状动脉病变狭窄的保护因素。结论 LDL-C与Lp（a）参与CHD的发生发展，可作为诊断CHD的参考依据，其表达水平与冠状动脉病变狭窄具有一定的相关性，临床上可用于评估冠状动脉病变狭窄程度。
Abstract:
Objective To analyze the correlation between blood lipid levels and stenosis of coronary artery disease in patients with coronary heart disease (CHD).Methods Selecting 350 patients admitted to our hospital from June 2018 to June 2019 with chest tightness and chest pain as the main complaint. Based on the results of coronary angiography, 150 patients with normal coronary angiography were selected as the control group. 200 patients diagnosed with coronary heart disease were set as the study group, and were divided into low-risk group (80 cases), intermediate-risk group (65 cases), and high-risk group (55 cases) based on Gensini points.Intraoral endoscopic myotomy compared the clinical data and blood lipid levels of the control group and the study group, compared the blood lipid levels of the low, middle and high-risk groups, and Logistic regression analysis of the correlation between the blood lipid levels of the study group and the degree of stenosis of coronary artery lesions.Results There was no significant difference in gender, age, BMI, drinking history, smoking history, diabetes history, hypertension history, systolic blood pressure, diastolic blood pressure, TG, Glu, TC, HDL-C between the two groups(P>0.05);The LDL-C and Lp (a) in the study group were higher than those in the control group,the differences were statistically significant (P<0.05). There was no significant difference in the levels of TG, TC, and HDL-C in the low, intermediate, and high-risk groups (P>0.05); the levels of LDL-C and Lp (a) in the low, intermediate, and high-risk groups increased in order, the differences were statistically significant (P<0.05). Logistic regression analysis showed that LDL-C and Lp (a) were risk factors for coronary artery disease stenosis; TC and HDL-C were protective factors for coronary artery disease stenosis.No correlation was found between TG and the degree of coronary atherosclerotic disease.Conclusion LDL-C and Lp (a) are involved in the occurrence and development of CHD, which can be used as a reference for the diagnosis of CHD. The expression level of LDL-C and Lp (a) has a certain correlation with coronary artery disease stenosis. It can be used clinically to evaluate the degree of coronary artery disease stenosis.

参考文献/References:

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更新日期/Last Update: 2020-02-01