[1]郑葆龙,肖绍文.CT23基因在脑肿瘤中的表达情况及临床价值[J].医学信息,2020,33(05):94-96.[doi:10.3969/j.issn.1006-1959.2020.05.028]
　ZHENG Bao-long,XIAO Shao-wen.CT23 Gene Expression in Brain Tumors and its Clinical Value[J].Medical Information,2020,33(05):94-96.[doi:10.3969/j.issn.1006-1959.2020.05.028]
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CT23基因在脑肿瘤中的表达情况及临床价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年05期
页码:
94-96
栏目:
论著
出版日期:
2020-03-01

文章信息/Info

Title:
CT23 Gene Expression in Brain Tumors and its Clinical Value
文章编号:
1006-1959（2020）05-0094-03
作者:
郑葆龙; 肖绍文
（广西医科大学第一附属医院神经外科，广西 南宁 530021）
Author(s):
ZHENG Bao-long; XIAO Shao-wen
(Department of Neurosurgery,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,Guangxi,China)
关键词:
CT23基因; 脑肿瘤; 癌-睾丸抗原; 逆转录聚合酶链反应
Keywords:
CT23 gene; Brain tumor; Cancer-testis antigen; Reverse transcription polymerase chain reaction
分类号:
R739.4
DOI:
10.3969/j.issn.1006-1959.2020.05.028
文献标志码:
A
摘要:
目的 检测和明确癌-睾丸相关抗原（CTA）CT23基因在人脑肿瘤中的表达情况，评估该基因潜在的临床价值。方法 收集广西医科大学第一附属医院神经外科14例颅脑肿瘤病理标本，包括星形细胞瘤5例，髓母细胞瘤4例，胶质母细胞瘤5例，使用RT-PCR技术检测CT23基因在不同病理类型的脑肿瘤中的表达情况，比较其在不同类型脑肿瘤中的表达差异。结果 14例脑肿瘤样本中13例CT23表达阳性，其中星形细胞瘤4例，胶质母细胞瘤5例，髓母细胞瘤4例，CT23基因在三类脑肿瘤样本中的表达比较，差异无统计学意义（P＞0.05）。结论 CT23基因作为一种肿瘤相关的基因，可表达于多种类型的人类脑肿瘤中，另外该基因的表达与脑肿瘤的发生、发展可能有关。
Abstract:
Objective To detect and clarify the expression of the cancer-testis-associated antigen (CTA) CT23 gene in human brain tumors, and to evaluate its potential clinical value. Methods Collected 14 cases of craniocerebral tumor pathological specimens from Neurosurgery Department of the First Affiliated Hospital of Guangxi Medical University, including 5 cases of astrocytoma, 4 cases of medulloblastoma, and 5 cases of glioblastoma. RT-PCR was used to detect the expression of CT23 gene in brain tumors of different pathological types, and to compare the expression difference of CT23 gene in different types of brain tumors.Results The CT23 gene expression was positive in 13 of 14 brain tumor samples, including 4 astrocytomas, 5 glioblastomas, and 4 medullary tumors. Comparison of CT23 gene expression in three types of brain tumor samples, the difference was not statistically significant (P>0.05).Conclusion As a tumor-related gene, CT23 gene can be expressed in many types of human brain tumors. In addition, the expression of this gene may be related to the occurrence and development of brain tumors.

参考文献/References:

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更新日期/Last Update: 2020-03-01